Human Mesenchymal Stem Cells Prevent Neurological Complications of Radiotherapy
Radiotherapy is a highly effective tool for the treatment of brain cancer. However, radiation also causes detrimental effects in the healthy tissue, leading to neurocognitive sequelae that compromise the quality of life of brain cancer patients. Despite the recognition of this serious complication,...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-05-01
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| Series: | Frontiers in Cellular Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fncel.2019.00204/full |
| _version_ | 1819163218960973824 |
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| author | Bernat Soria Bernat Soria Alejandro Martin-Montalvo Yolanda Aguilera Nuria Mellado-Damas Javier López-Beas Isabel Herrera-Herrera Escarlata López Juan A. Barcia Manuel Alvarez-Dolado Abdelkrim Hmadcha Abdelkrim Hmadcha Vivian Capilla-González |
| author_facet | Bernat Soria Bernat Soria Alejandro Martin-Montalvo Yolanda Aguilera Nuria Mellado-Damas Javier López-Beas Isabel Herrera-Herrera Escarlata López Juan A. Barcia Manuel Alvarez-Dolado Abdelkrim Hmadcha Abdelkrim Hmadcha Vivian Capilla-González |
| author_sort | Bernat Soria |
| collection | DOAJ |
| description | Radiotherapy is a highly effective tool for the treatment of brain cancer. However, radiation also causes detrimental effects in the healthy tissue, leading to neurocognitive sequelae that compromise the quality of life of brain cancer patients. Despite the recognition of this serious complication, no satisfactory solutions exist at present. Here we investigated the effects of intranasal administration of human mesenchymal stem cells (hMSCs) as a neuroprotective strategy for cranial radiation in mice. Our results demonstrated that intranasally delivered hMSCs promote radiation-induced brain injury repair, improving neurological function. This intervention confers protection against inflammation, oxidative stress, and neuronal loss. hMSC administration reduces persistent activation of damage-induced c-AMP response element-binding signaling in irradiated brains. Furthermore, hMSC treatment did not compromise the survival of glioma-bearing mice. Our findings encourage the therapeutic use of hMSCs as a non-invasive approach to prevent neurological complications of radiotherapy, improving the quality of life of brain tumor patients. |
| first_indexed | 2024-12-22T17:40:39Z |
| format | Article |
| id | doaj.art-b726e4516afd48f2b3bd2ae16812d2a9 |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-12-22T17:40:39Z |
| publishDate | 2019-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-b726e4516afd48f2b3bd2ae16812d2a92022-12-21T18:18:25ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022019-05-011310.3389/fncel.2019.00204451770Human Mesenchymal Stem Cells Prevent Neurological Complications of RadiotherapyBernat Soria0Bernat Soria1Alejandro Martin-Montalvo2Yolanda Aguilera3Nuria Mellado-Damas4Javier López-Beas5Isabel Herrera-Herrera6Escarlata López7Juan A. Barcia8Manuel Alvarez-Dolado9Abdelkrim Hmadcha10Abdelkrim Hmadcha11Vivian Capilla-González12Department of Regeneration and Cell Therapy, Andalusian Center for Molecular Biology and Regenerative Medicine (CABIMER), University of Pablo de Olavide – University of Seville, CSIC, Seville, SpainCentro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Madrid, SpainDepartment of Regeneration and Cell Therapy, Andalusian Center for Molecular Biology and Regenerative Medicine (CABIMER), University of Pablo de Olavide – University of Seville, CSIC, Seville, SpainDepartment of Regeneration and Cell Therapy, Andalusian Center for Molecular Biology and Regenerative Medicine (CABIMER), University of Pablo de Olavide – University of Seville, CSIC, Seville, SpainDepartment of Regeneration and Cell Therapy, Andalusian Center for Molecular Biology and Regenerative Medicine (CABIMER), University of Pablo de Olavide – University of Seville, CSIC, Seville, SpainDepartment of Regeneration and Cell Therapy, Andalusian Center for Molecular Biology and Regenerative Medicine (CABIMER), University of Pablo de Olavide – University of Seville, CSIC, Seville, SpainDepartment of Neuroradiology, Hospital Universitario Fundación Jiménez Díaz, Madrid, SpainDepartment of Radiation Oncology, Hospital Universitario Fundación Jiménez Díaz, Madrid, SpainService of Neurosurgery, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria San Carlos (IdISSC), Department of Surgery, Universidad Complutense de Madrid, Madrid, SpainDepartment of Regeneration and Cell Therapy, Andalusian Center for Molecular Biology and Regenerative Medicine (CABIMER), University of Pablo de Olavide – University of Seville, CSIC, Seville, SpainDepartment of Regeneration and Cell Therapy, Andalusian Center for Molecular Biology and Regenerative Medicine (CABIMER), University of Pablo de Olavide – University of Seville, CSIC, Seville, SpainCentro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Madrid, SpainDepartment of Regeneration and Cell Therapy, Andalusian Center for Molecular Biology and Regenerative Medicine (CABIMER), University of Pablo de Olavide – University of Seville, CSIC, Seville, SpainRadiotherapy is a highly effective tool for the treatment of brain cancer. However, radiation also causes detrimental effects in the healthy tissue, leading to neurocognitive sequelae that compromise the quality of life of brain cancer patients. Despite the recognition of this serious complication, no satisfactory solutions exist at present. Here we investigated the effects of intranasal administration of human mesenchymal stem cells (hMSCs) as a neuroprotective strategy for cranial radiation in mice. Our results demonstrated that intranasally delivered hMSCs promote radiation-induced brain injury repair, improving neurological function. This intervention confers protection against inflammation, oxidative stress, and neuronal loss. hMSC administration reduces persistent activation of damage-induced c-AMP response element-binding signaling in irradiated brains. Furthermore, hMSC treatment did not compromise the survival of glioma-bearing mice. Our findings encourage the therapeutic use of hMSCs as a non-invasive approach to prevent neurological complications of radiotherapy, improving the quality of life of brain tumor patients.https://www.frontiersin.org/article/10.3389/fncel.2019.00204/fullradiotherapystem cellscognitionneuroprotectionintranasal cell deliveryCREB |
| spellingShingle | Bernat Soria Bernat Soria Alejandro Martin-Montalvo Yolanda Aguilera Nuria Mellado-Damas Javier López-Beas Isabel Herrera-Herrera Escarlata López Juan A. Barcia Manuel Alvarez-Dolado Abdelkrim Hmadcha Abdelkrim Hmadcha Vivian Capilla-González Human Mesenchymal Stem Cells Prevent Neurological Complications of Radiotherapy Frontiers in Cellular Neuroscience radiotherapy stem cells cognition neuroprotection intranasal cell delivery CREB |
| title | Human Mesenchymal Stem Cells Prevent Neurological Complications of Radiotherapy |
| title_full | Human Mesenchymal Stem Cells Prevent Neurological Complications of Radiotherapy |
| title_fullStr | Human Mesenchymal Stem Cells Prevent Neurological Complications of Radiotherapy |
| title_full_unstemmed | Human Mesenchymal Stem Cells Prevent Neurological Complications of Radiotherapy |
| title_short | Human Mesenchymal Stem Cells Prevent Neurological Complications of Radiotherapy |
| title_sort | human mesenchymal stem cells prevent neurological complications of radiotherapy |
| topic | radiotherapy stem cells cognition neuroprotection intranasal cell delivery CREB |
| url | https://www.frontiersin.org/article/10.3389/fncel.2019.00204/full |
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