Fluorotetrahydroquinolines from Diethyl 2-Fluoromalonate Ester

Fluorotetrahydroquinolines from Diethyl 2-Fluoromalonate Ester

A short series of fluorotetrahydroquinolines was synthesised in two steps from diethyl fluoromalonate and appropriate ortho-nitrobenzyl bromide precursors.

Bibliographic Details
Main Authors:	Craig A. Fisher, Antal Harsanyi, Graham Sandford, Dmitri S. Yufit, Judith A. K. Howard
Format:	Article
Language:	deu
Published:	Swiss Chemical Society 2014-06-01
Series:	CHIMIA
Subjects:	Fluorinated heterocycle Fluoromalonate Fluorotetrahydroquinoline Organofluorine chemistry Selective fluorination
Online Access:	https://www.chimia.ch/chimia/article/view/5586

Similar Items

Syntheses of fluorooxindole and 2-fluoro-2-arylacetic acid derivatives from diethyl 2-fluoromalonate ester
by: Antal Harsanyi, et al.
Published: (2014-05-01)

Synthesis of 2,2-difluoro-1,3-diketone and 2,2-difluoro-1,3-ketoester derivatives using fluorine gas
by: Alexander S. Hampton, et al.
Published: (2024-02-01)

MÉTODOS SELETIVOS DE FLUORAÇÃO DE MOLÉCULAS ORGÂNICAS
by: Núbia Boechat, et al.
Published: (2015-12-01)

Bioorganic and medicinal chemistry of fluorine /
by: 407746 Begue, Jean-Pierre, et al.
Published: (2008)

Fluorine in the Life Sciences International Symposium, Bürgenstock (Switzerland), 6–9 July 2003
by: Antonio Togni
Published: (2003-09-01)

Diethyl (1-benzyl-4-phenyl-3-trifluoromethyl-1H-pyrrol-2-yl)phosphonate
by: Anna Jezuita, et al.
Published: (2017-08-01)

Fluoroalkyl Amino Reagents (FARs): A General Approach towards the Synthesis of Heterocyclic Compounds Bearing Emergent Fluorinated Substituents
by: Bruno Commare, et al.
Published: (2017-06-01)

Continuous gas/liquid–liquid/liquid flow synthesis of 4-fluoropyrazole derivatives by selective direct fluorination
by: Jessica R. Breen, et al.
Published: (2011-08-01)

FDA-Approved Fluorinated Heterocyclic Drugs from 2016 to 2022
by: Carla Rizzo, et al.
Published: (2023-04-01)

Fluorine-containing substituents: metabolism of the α,α-difluoroethyl thioether motif
by: Andrea Rodil, et al.
Published: (2019-06-01)

Stereoselectively fluorinated N-heterocycles: a brief survey
by: Xiang-Guo Hu, et al.
Published: (2013-11-01)

Handbook of fluorous chemistry /
by: Gladysz, John A., et al.
Published: (2004)

Flourine and its compounds [kasetvideo]
by: Open University. An Algorithmic Approach to Computing Course Team
Published: (1971)

Fluorine and its compounds [filem]
by: Open University
Published: (1971)

Fluorine chemistry research advances /
by: Gardiner, Ira V.
Published: (c200)

Electrochemical Synthesis of Fluorinated Orthoesters from 1,3‐Benzodioxoles
by: Johannes L. Röckl, et al.
Published: (2019-09-01)

Fluorine-Containing Drug Administration in Rats Results in Fluorination of Selected Proteins in Liver and Brain Tissue
by: Andrzej Gawor, et al.
Published: (2022-04-01)

Advances in the Synthesis of Fluorinated Scaffolds by Transition Metal-Catalyzed C–H Bond Activation
by: Sara Mazet, et al.
Published: (2020-11-01)

2-(Fluoromethyl)-4,7-dimethoxy-1-methyl-1<i>H</i>-benzimidazole
by: Patrick Kielty, et al.
Published: (2020-05-01)

Flow microreactor synthesis in organo-fluorine chemistry
by: Hideki Amii, et al.
Published: (2013-12-01)

Synthesis of Fluorinated 3,6-Dihydropyridines and 2-(Fluoromethyl)pyridines by Electrophilic Fluorination of 1,2-Dihydropyridines with Selectfluor<sup>®</sup>
by: Nadiia V. Pikun, et al.
Published: (2020-07-01)

The chemistry of fluorine/
by: O'Donnell, T. A. (Thomas Aloysius)
Published: (1973)

Synthesis of new triazole-based trifluoromethyl scaffolds
by: Michela Martinelli, et al.
Published: (2008-05-01)

Synthesis of 1-(4-Trifluoromethoxyphenyl)-2,5-dimethyl-3-(2-R-thiazol-4-yl)-1H-pyrroles via Chain Heterocyclization
by: Andrij O. Tolmachov, et al.
Published: (2010-02-01)

Organic fluorine chemistry/
by: 221585 Hudlicky, Milos
Published: (1971)

Analytical chemistry of fluorine/
by: Nikolaev, N. S.
Published: (1972)

Toxic properties of inorganic fluorine compounds/
by: 221619 Eagers, R. Y.
Published: (1969)

Fluorine and its compounds/
by: 221907 Haszeldine, R. N., et al.
Published: (1951)

Journal of fluorine chemistry
Published: (1971)

Microfluidics-Based Reactors for Safe Fluorinations Using Elemental Fluorine
by: Michael D. Turnbull, et al.
Published: (2004-03-01)

Overview of the Development of the Fluoropolymer Industry
by: Hongxiang Teng
Published: (2012-05-01)

Transition-metal-catalyzed C–H bond activation as a sustainable strategy for the synthesis of fluorinated molecules: an overview
by: Louis Monsigny, et al.
Published: (2023-04-01)

2-Aryl-6-Polyfluoroalkyl-4-Pyrones as Promising R<sup>F</sup>-Building-Blocks: Synthesis and Application for Construction of Fluorinated Azaheterocycles
by: Sergey A. Usachev, et al.
Published: (2021-07-01)

Antiparasitic Activity of Fluorophenyl-Substituted Pyrimido[1,2-<i>a</i>]benzimidazoles
by: Ibrahim S. Al Nasr, et al.
Published: (2023-01-01)

Automated Synthesis of Fluorine-18 Labeled CXCR4 Ligand via the Conjugation with Nicotinic Acid <i>N</i>-Hydroxysuccinimide Ester (6-[<sup>18</sup>F]SFPy)
by: Falguni Basuli, et al.
Published: (2020-08-01)

Oxadiazolyl-Pyridinium as Cationic Scaffold for Fluorinated Ionic Liquid Crystals
by: Melina S. Weber, et al.
Published: (2021-11-01)

Shaping 1,2,4-Triazolium Fluorinated Ionic Liquid Crystals
by: Carla Rizzo, et al.
Published: (2023-02-01)

The influence of fluorine and its compounds on people’s health (literature review)
by: I. V. Donskikh
Published: (2013-05-01)

FLUORIDE REDUCTION FROM WATER BY PRECIPITATION WITH CALCIUM CHLORIDE AND LIME
by: A. Hoggui
Published: (2013-12-01)

The difluoromethylene (CF2) group in aliphatic chains: Synthesis and conformational preference of palmitic acids and nonadecane containing CF2 groups
by: Yi Wang, et al.
Published: (2014-01-01)