Photosynthesis-Inhibiting Activity of 1-[(2-Chlorophenyl)carbamoyl]- and 1-[(2-Nitrophenyl)carbamoyl]naphthalen-2-yl Alkylcarbamates
Eight 1-[(2-chlorophenyl)carbamoyl]naphthalen-2-yl alkylcarbamates and eight 1-[(2-nitrophenyl)carbamoyl]naphthalen-2-yl alkylcarbamates were tested for their activity related to the inhibition of photosynthetic electron transport (PET) in spinach (Spinacia oleracea L.) chloroplasts. The PET-inhibit...
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MDPI AG
2017-07-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/22/7/1199 |
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| author | Tomas Gonec Josef Stranik Matus Pesko Jiri Kos Michal Oravec Katarina Kralova Josef Jampilek |
| author_facet | Tomas Gonec Josef Stranik Matus Pesko Jiri Kos Michal Oravec Katarina Kralova Josef Jampilek |
| author_sort | Tomas Gonec |
| collection | DOAJ |
| description | Eight 1-[(2-chlorophenyl)carbamoyl]naphthalen-2-yl alkylcarbamates and eight 1-[(2-nitrophenyl)carbamoyl]naphthalen-2-yl alkylcarbamates were tested for their activity related to the inhibition of photosynthetic electron transport (PET) in spinach (Spinacia oleracea L.) chloroplasts. The PET-inhibiting activity of the compounds was relatively low; the corresponding IC50 values ranged from 0.05 to 0.664 mmol/L; and the highest activity within the series of compounds was observed for 1-[(2-chlorophenyl)-carbamoyl]naphthalen-2-yl propylcarbamate. It has been proven that the compounds are PET-inhibitors in photosystem II. Despite rather low PET-inhibiting activities, primary structure-activity trends can be discussed. |
| first_indexed | 2024-12-21T17:03:22Z |
| format | Article |
| id | doaj.art-b72c9130e5084d449085190efbe2ed87 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-21T17:03:22Z |
| publishDate | 2017-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-b72c9130e5084d449085190efbe2ed872022-12-21T18:56:35ZengMDPI AGMolecules1420-30492017-07-01227119910.3390/molecules22071199molecules22071199Photosynthesis-Inhibiting Activity of 1-[(2-Chlorophenyl)carbamoyl]- and 1-[(2-Nitrophenyl)carbamoyl]naphthalen-2-yl AlkylcarbamatesTomas Gonec0Josef Stranik1Matus Pesko2Jiri Kos3Michal Oravec4Katarina Kralova5Josef Jampilek6Department of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Palackeho 1, 61242 Brno, Czech RepublicDepartment of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Palackeho 1, 61242 Brno, Czech RepublicDepartment of Environmental Ecology, Faculty of Natural Sciences, Comenius University, Ilkovicova 6, 84215 Bratislava, SlovakiaDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Comenius University, Odbojarov 10, 83232 Bratislava, SlovakiaGlobal Change Research Institute CAS, Belidla 986/4a, 60300 Brno, Czech RepublicInstitute of Chemistry, Faculty of Natural Sciences, Comenius University, Ilkovicova 6, 84215 Bratislava, SlovakiaDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Comenius University, Odbojarov 10, 83232 Bratislava, SlovakiaEight 1-[(2-chlorophenyl)carbamoyl]naphthalen-2-yl alkylcarbamates and eight 1-[(2-nitrophenyl)carbamoyl]naphthalen-2-yl alkylcarbamates were tested for their activity related to the inhibition of photosynthetic electron transport (PET) in spinach (Spinacia oleracea L.) chloroplasts. The PET-inhibiting activity of the compounds was relatively low; the corresponding IC50 values ranged from 0.05 to 0.664 mmol/L; and the highest activity within the series of compounds was observed for 1-[(2-chlorophenyl)-carbamoyl]naphthalen-2-yl propylcarbamate. It has been proven that the compounds are PET-inhibitors in photosystem II. Despite rather low PET-inhibiting activities, primary structure-activity trends can be discussed.https://www.mdpi.com/1420-3049/22/7/1199alkylcarbamateshydroxynaphthalene-carboxamidesPET inhibitionspinach chloroplastsstructure-activity relationships |
| spellingShingle | Tomas Gonec Josef Stranik Matus Pesko Jiri Kos Michal Oravec Katarina Kralova Josef Jampilek Photosynthesis-Inhibiting Activity of 1-[(2-Chlorophenyl)carbamoyl]- and 1-[(2-Nitrophenyl)carbamoyl]naphthalen-2-yl Alkylcarbamates Molecules alkylcarbamates hydroxynaphthalene-carboxamides PET inhibition spinach chloroplasts structure-activity relationships |
| title | Photosynthesis-Inhibiting Activity of 1-[(2-Chlorophenyl)carbamoyl]- and 1-[(2-Nitrophenyl)carbamoyl]naphthalen-2-yl Alkylcarbamates |
| title_full | Photosynthesis-Inhibiting Activity of 1-[(2-Chlorophenyl)carbamoyl]- and 1-[(2-Nitrophenyl)carbamoyl]naphthalen-2-yl Alkylcarbamates |
| title_fullStr | Photosynthesis-Inhibiting Activity of 1-[(2-Chlorophenyl)carbamoyl]- and 1-[(2-Nitrophenyl)carbamoyl]naphthalen-2-yl Alkylcarbamates |
| title_full_unstemmed | Photosynthesis-Inhibiting Activity of 1-[(2-Chlorophenyl)carbamoyl]- and 1-[(2-Nitrophenyl)carbamoyl]naphthalen-2-yl Alkylcarbamates |
| title_short | Photosynthesis-Inhibiting Activity of 1-[(2-Chlorophenyl)carbamoyl]- and 1-[(2-Nitrophenyl)carbamoyl]naphthalen-2-yl Alkylcarbamates |
| title_sort | photosynthesis inhibiting activity of 1 2 chlorophenyl carbamoyl and 1 2 nitrophenyl carbamoyl naphthalen 2 yl alkylcarbamates |
| topic | alkylcarbamates hydroxynaphthalene-carboxamides PET inhibition spinach chloroplasts structure-activity relationships |
| url | https://www.mdpi.com/1420-3049/22/7/1199 |
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