Increased prevalence of methicillin-resistant <it>Staphylococcus aureus </it>nasal colonization in household contacts of children with community acquired disease
<p>Abstract</p> <p>Background</p> <p>To measure Methicillin-resistant <it>Staphylococcus aureus </it>(MRSA) nasal colonization prevalence in household contacts of children with current community associated (CA)-MRSA infections (study group) in comparison wit...
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| Format: | Article |
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BMC
2012-02-01
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| Series: | BMC Infectious Diseases |
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| Online Access: | http://www.biomedcentral.com/1471-2334/12/45 |
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| author | Rafee Yaseen Abdel-Haq Nahed Asmar Basim Salimnia Tanaz Pharm Celine Rybak Pharm Michael J Amjad Muhammad |
| author_facet | Rafee Yaseen Abdel-Haq Nahed Asmar Basim Salimnia Tanaz Pharm Celine Rybak Pharm Michael J Amjad Muhammad |
| author_sort | Rafee Yaseen |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>To measure Methicillin-resistant <it>Staphylococcus aureus </it>(MRSA) nasal colonization prevalence in household contacts of children with current community associated (CA)-MRSA infections (study group) in comparison with a group of household contacts of children without suspected <it>Staphylococcus aureus </it>infection (a control group).</p> <p>Methods</p> <p>This is a cross sectional study. Cultures of the anterior nares were taken. Relatedness of isolated strains was tested using pulse field gel electrophoresis (PFGE).</p> <p>Results</p> <p>The prevalence of MRSA colonization in the study group was significantly higher than in the control group (18/77 (23%) vs 3/77 (3.9%); p ≤ 0.001). The prevalence of SA colonization was 28/77 (36%) in the study group and 16/77 (21%) in the control group (p = 0.032). The prevalence of SA nasal colonization among patients was 6/24 (25%); one with methicillin-susceptible <it>S. aureus </it>(MSSA) and 5 with MRSA. In the study (patient) group, 14/24 (58%) families had at least one household member who was colonized with MRSA compared to 2/29 (6.9%) in the control group (p = 0.001). Of 69 total isolates tested by PFGE, 40 (58%) were related to USA300. Panton-Valetine leukocidin (PVL) genes were detected in 30/52 (58%) tested isolates. Among the families with ≥1 contact colonized with MRSA, similar PFGE profiles were found between the index patient and a contact in 10/14 families.</p> <p>Conclusions</p> <p>Prevalence of asymptomatic nasal carriage of MRSA is higher among household contacts of patients with CA-MRSA disease than control group. Decolonizing such carriers may help prevent recurrent CA-MRSA infections.</p> |
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| format | Article |
| id | doaj.art-b72d0c4c40214604bdea988f4561e131 |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-12-12T05:48:37Z |
| publishDate | 2012-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-b72d0c4c40214604bdea988f4561e1312022-12-22T00:35:44ZengBMCBMC Infectious Diseases1471-23342012-02-011214510.1186/1471-2334-12-45Increased prevalence of methicillin-resistant <it>Staphylococcus aureus </it>nasal colonization in household contacts of children with community acquired diseaseRafee YaseenAbdel-Haq NahedAsmar BasimSalimnia TanazPharm CelineRybak Pharm Michael JAmjad Muhammad<p>Abstract</p> <p>Background</p> <p>To measure Methicillin-resistant <it>Staphylococcus aureus </it>(MRSA) nasal colonization prevalence in household contacts of children with current community associated (CA)-MRSA infections (study group) in comparison with a group of household contacts of children without suspected <it>Staphylococcus aureus </it>infection (a control group).</p> <p>Methods</p> <p>This is a cross sectional study. Cultures of the anterior nares were taken. Relatedness of isolated strains was tested using pulse field gel electrophoresis (PFGE).</p> <p>Results</p> <p>The prevalence of MRSA colonization in the study group was significantly higher than in the control group (18/77 (23%) vs 3/77 (3.9%); p ≤ 0.001). The prevalence of SA colonization was 28/77 (36%) in the study group and 16/77 (21%) in the control group (p = 0.032). The prevalence of SA nasal colonization among patients was 6/24 (25%); one with methicillin-susceptible <it>S. aureus </it>(MSSA) and 5 with MRSA. In the study (patient) group, 14/24 (58%) families had at least one household member who was colonized with MRSA compared to 2/29 (6.9%) in the control group (p = 0.001). Of 69 total isolates tested by PFGE, 40 (58%) were related to USA300. Panton-Valetine leukocidin (PVL) genes were detected in 30/52 (58%) tested isolates. Among the families with ≥1 contact colonized with MRSA, similar PFGE profiles were found between the index patient and a contact in 10/14 families.</p> <p>Conclusions</p> <p>Prevalence of asymptomatic nasal carriage of MRSA is higher among household contacts of patients with CA-MRSA disease than control group. Decolonizing such carriers may help prevent recurrent CA-MRSA infections.</p>http://www.biomedcentral.com/1471-2334/12/45MRSAChildrenNasal colonization |
| spellingShingle | Rafee Yaseen Abdel-Haq Nahed Asmar Basim Salimnia Tanaz Pharm Celine Rybak Pharm Michael J Amjad Muhammad Increased prevalence of methicillin-resistant <it>Staphylococcus aureus </it>nasal colonization in household contacts of children with community acquired disease BMC Infectious Diseases MRSA Children Nasal colonization |
| title | Increased prevalence of methicillin-resistant <it>Staphylococcus aureus </it>nasal colonization in household contacts of children with community acquired disease |
| title_full | Increased prevalence of methicillin-resistant <it>Staphylococcus aureus </it>nasal colonization in household contacts of children with community acquired disease |
| title_fullStr | Increased prevalence of methicillin-resistant <it>Staphylococcus aureus </it>nasal colonization in household contacts of children with community acquired disease |
| title_full_unstemmed | Increased prevalence of methicillin-resistant <it>Staphylococcus aureus </it>nasal colonization in household contacts of children with community acquired disease |
| title_short | Increased prevalence of methicillin-resistant <it>Staphylococcus aureus </it>nasal colonization in household contacts of children with community acquired disease |
| title_sort | increased prevalence of methicillin resistant it staphylococcus aureus it nasal colonization in household contacts of children with community acquired disease |
| topic | MRSA Children Nasal colonization |
| url | http://www.biomedcentral.com/1471-2334/12/45 |
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