The association between prolonged sedentary time and coronary artery calcification in young healthy men in Korea: a cohort study
Abstract Coronary artery calcium score (CACS) is a useful method for predicting coronary artery disease in asymptomatic adults. In this study, we investigated the association between prolonged sedentary time and CACS. A cohort study was conducted in 14949 men with negative CACS (CACS = 0) at baselin...
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Nature Portfolio
2022-02-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-06739-x |
| _version_ | 1819277927824490496 |
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| author | Min-Woo Nam Yesung Lee Woncheol Lee |
| author_facet | Min-Woo Nam Yesung Lee Woncheol Lee |
| author_sort | Min-Woo Nam |
| collection | DOAJ |
| description | Abstract Coronary artery calcium score (CACS) is a useful method for predicting coronary artery disease in asymptomatic adults. In this study, we investigated the association between prolonged sedentary time and CACS. A cohort study was conducted in 14949 men with negative CACS (CACS = 0) at baseline who were followed up at least once. Sedentary time was categorized into < 7, 7–8, and ≥ 9 h/day. CACS was calculated by cardiac tomography. During 60,112.1 person-years of follow-up, 569 participants developed positive CACS. The multivariable adjusted hazard ratios (95% confidence intervals) for incident positive CACS comparing sedentary times of 7–8 h/day and ≥ 9 h/day to sedentary time of < 7 h/day were 1.25 (0.97–1.62) and 1.28 (1.03–1.59), respectively. This association was more strongly observed in the non-obese group (BMI < 25 kg/m2). In contrast, in the obese group (BMI ≥ 25 kg/m2), there was no significant association between sedentary time and incidence of positive CACS. Prolonged sedentary time was significantly associated with incidence of positive CACS in the study. CACS is also an effective screening tool for predicting future cardiovascular events in asymptomatic patients. Therefore, CACS can be an effective screening method for predicting coronary artery diseases in people with prolonged sedentary time, especially in metabolically healthy people. |
| first_indexed | 2024-12-24T00:03:54Z |
| format | Article |
| id | doaj.art-b72d4652a0464750a95c2c17cce47dba |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-24T00:03:54Z |
| publishDate | 2022-02-01 |
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| spelling | doaj.art-b72d4652a0464750a95c2c17cce47dba2022-12-21T17:25:04ZengNature PortfolioScientific Reports2045-23222022-02-011211710.1038/s41598-022-06739-xThe association between prolonged sedentary time and coronary artery calcification in young healthy men in Korea: a cohort studyMin-Woo Nam0Yesung Lee1Woncheol Lee2Department of Occupational and Environmental Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of MedicineDepartment of Occupational and Environmental Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of MedicineDepartment of Occupational and Environmental Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of MedicineAbstract Coronary artery calcium score (CACS) is a useful method for predicting coronary artery disease in asymptomatic adults. In this study, we investigated the association between prolonged sedentary time and CACS. A cohort study was conducted in 14949 men with negative CACS (CACS = 0) at baseline who were followed up at least once. Sedentary time was categorized into < 7, 7–8, and ≥ 9 h/day. CACS was calculated by cardiac tomography. During 60,112.1 person-years of follow-up, 569 participants developed positive CACS. The multivariable adjusted hazard ratios (95% confidence intervals) for incident positive CACS comparing sedentary times of 7–8 h/day and ≥ 9 h/day to sedentary time of < 7 h/day were 1.25 (0.97–1.62) and 1.28 (1.03–1.59), respectively. This association was more strongly observed in the non-obese group (BMI < 25 kg/m2). In contrast, in the obese group (BMI ≥ 25 kg/m2), there was no significant association between sedentary time and incidence of positive CACS. Prolonged sedentary time was significantly associated with incidence of positive CACS in the study. CACS is also an effective screening tool for predicting future cardiovascular events in asymptomatic patients. Therefore, CACS can be an effective screening method for predicting coronary artery diseases in people with prolonged sedentary time, especially in metabolically healthy people.https://doi.org/10.1038/s41598-022-06739-x |
| spellingShingle | Min-Woo Nam Yesung Lee Woncheol Lee The association between prolonged sedentary time and coronary artery calcification in young healthy men in Korea: a cohort study Scientific Reports |
| title | The association between prolonged sedentary time and coronary artery calcification in young healthy men in Korea: a cohort study |
| title_full | The association between prolonged sedentary time and coronary artery calcification in young healthy men in Korea: a cohort study |
| title_fullStr | The association between prolonged sedentary time and coronary artery calcification in young healthy men in Korea: a cohort study |
| title_full_unstemmed | The association between prolonged sedentary time and coronary artery calcification in young healthy men in Korea: a cohort study |
| title_short | The association between prolonged sedentary time and coronary artery calcification in young healthy men in Korea: a cohort study |
| title_sort | association between prolonged sedentary time and coronary artery calcification in young healthy men in korea a cohort study |
| url | https://doi.org/10.1038/s41598-022-06739-x |
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