CD8 T-cells from most HIV-infected patients lack ex vivo HIV-suppressive capacity during acute and early infection.
The strong CD8+ T-cell-mediated HIV-1-suppressive capacity found in a minority of HIV-infected patients in chronic infection is associated with spontaneous control of viremia. However, it is still unclear whether such capacities were also present earlier in the CD8+ T cells from non controller patie...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3612088?pdf=render |
| _version_ | 1828847182189428736 |
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| author | Camille Lécuroux Isabelle Girault Antoine Chéret Pierre Versmisse Georges Nembot Laurence Meyer Christine Rouzioux Gianfranco Pancino Alain Venet Asier Sáez-Cirión ANRS 147 OPTIPRIM clinical trial |
| author_facet | Camille Lécuroux Isabelle Girault Antoine Chéret Pierre Versmisse Georges Nembot Laurence Meyer Christine Rouzioux Gianfranco Pancino Alain Venet Asier Sáez-Cirión ANRS 147 OPTIPRIM clinical trial |
| author_sort | Camille Lécuroux |
| collection | DOAJ |
| description | The strong CD8+ T-cell-mediated HIV-1-suppressive capacity found in a minority of HIV-infected patients in chronic infection is associated with spontaneous control of viremia. However, it is still unclear whether such capacities were also present earlier in the CD8+ T cells from non controller patients and then lost as a consequence of uncontrolled viral replication. We studied 50 patients with primary HIV-1-infection to determine whether strong CD8+ T-cell-mediated HIV suppression is more often observed at that time. Despite high frequencies of polyfunctional HIV-specific CD8+ T-cells and a strong CD4+ T-helper response, CD8+ T-cells from 48 patients lacked strong HIV-suppressive capacities ex vivo. This indicates that the superior HIV-suppressive capacity of CD8+ T-cells from HIV controllers is not a general characteristic of the HIV-specific CD8+ T cell response in primary HIV infection. |
| first_indexed | 2024-12-12T22:03:14Z |
| format | Article |
| id | doaj.art-b72e95dc3ebb4c479e1705fc8a890ba9 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-12T22:03:14Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-b72e95dc3ebb4c479e1705fc8a890ba92022-12-22T00:10:27ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0183e5976710.1371/journal.pone.0059767CD8 T-cells from most HIV-infected patients lack ex vivo HIV-suppressive capacity during acute and early infection.Camille LécurouxIsabelle GiraultAntoine ChéretPierre VersmisseGeorges NembotLaurence MeyerChristine RouziouxGianfranco PancinoAlain VenetAsier Sáez-CiriónANRS 147 OPTIPRIM clinical trialThe strong CD8+ T-cell-mediated HIV-1-suppressive capacity found in a minority of HIV-infected patients in chronic infection is associated with spontaneous control of viremia. However, it is still unclear whether such capacities were also present earlier in the CD8+ T cells from non controller patients and then lost as a consequence of uncontrolled viral replication. We studied 50 patients with primary HIV-1-infection to determine whether strong CD8+ T-cell-mediated HIV suppression is more often observed at that time. Despite high frequencies of polyfunctional HIV-specific CD8+ T-cells and a strong CD4+ T-helper response, CD8+ T-cells from 48 patients lacked strong HIV-suppressive capacities ex vivo. This indicates that the superior HIV-suppressive capacity of CD8+ T-cells from HIV controllers is not a general characteristic of the HIV-specific CD8+ T cell response in primary HIV infection.http://europepmc.org/articles/PMC3612088?pdf=render |
| spellingShingle | Camille Lécuroux Isabelle Girault Antoine Chéret Pierre Versmisse Georges Nembot Laurence Meyer Christine Rouzioux Gianfranco Pancino Alain Venet Asier Sáez-Cirión ANRS 147 OPTIPRIM clinical trial CD8 T-cells from most HIV-infected patients lack ex vivo HIV-suppressive capacity during acute and early infection. PLoS ONE |
| title | CD8 T-cells from most HIV-infected patients lack ex vivo HIV-suppressive capacity during acute and early infection. |
| title_full | CD8 T-cells from most HIV-infected patients lack ex vivo HIV-suppressive capacity during acute and early infection. |
| title_fullStr | CD8 T-cells from most HIV-infected patients lack ex vivo HIV-suppressive capacity during acute and early infection. |
| title_full_unstemmed | CD8 T-cells from most HIV-infected patients lack ex vivo HIV-suppressive capacity during acute and early infection. |
| title_short | CD8 T-cells from most HIV-infected patients lack ex vivo HIV-suppressive capacity during acute and early infection. |
| title_sort | cd8 t cells from most hiv infected patients lack ex vivo hiv suppressive capacity during acute and early infection |
| url | http://europepmc.org/articles/PMC3612088?pdf=render |
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