Risks for animal and human health related to the presence of polychlorinated naphthalenes (PCNs) in feed and food
Abstract EFSA was asked for a scientific opinion on the risks for animal and human health related to the presence of polychlorinated naphthalenes (PCNs) in feed and food. The assessment focused on hexaCNs due to very limited data on other PCN congeners. For hexaCNs in feed, 217 analytical results we...
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| Format: | Article |
| Language: | English |
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Wiley
2024-03-01
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| Series: | EFSA Journal |
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| Online Access: | https://doi.org/10.2903/j.efsa.2024.8640 |
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| author | EFSA Panel name on Contaminants in the Food Chain (CONTAM) Dieter Schrenk Margherita Bignami Laurent Bodin James Kevin Chipman Jesús delMazo Bettina Grasl‐Kraupp Christer Hogstrand Laurentius (Ron) Hoogenboom Jean‐Charles Leblanc Carlo Stefano Nebbia Evangelia Ntzani Annette Petersen Salomon Sand Tanja Schwerdtle Christiane Vleminckx Heather Wallace Jerzy Falandysz Andrew Hart Martin Rose Maria Anastassiadou Chantra Eskes Petra Gergelova Matteo Innocenti Elena Rovesti Ben Whitty Elsa Nielsen |
| author_facet | EFSA Panel name on Contaminants in the Food Chain (CONTAM) Dieter Schrenk Margherita Bignami Laurent Bodin James Kevin Chipman Jesús delMazo Bettina Grasl‐Kraupp Christer Hogstrand Laurentius (Ron) Hoogenboom Jean‐Charles Leblanc Carlo Stefano Nebbia Evangelia Ntzani Annette Petersen Salomon Sand Tanja Schwerdtle Christiane Vleminckx Heather Wallace Jerzy Falandysz Andrew Hart Martin Rose Maria Anastassiadou Chantra Eskes Petra Gergelova Matteo Innocenti Elena Rovesti Ben Whitty Elsa Nielsen |
| author_sort | EFSA Panel name on Contaminants in the Food Chain (CONTAM) |
| collection | DOAJ |
| description | Abstract EFSA was asked for a scientific opinion on the risks for animal and human health related to the presence of polychlorinated naphthalenes (PCNs) in feed and food. The assessment focused on hexaCNs due to very limited data on other PCN congeners. For hexaCNs in feed, 217 analytical results were used to estimate dietary exposures for food‐producing and non‐food‐producing animals; however, a risk characterisation could not be performed because none of the toxicological studies allowed identification of reference points. The oral repeated dose toxicity studies performed in rats with a hexaCN mixture containing all 10 hexaCNs indicated that the critical target was the haematological system. A BMDL20 of 0.05 mg/kg body weight (bw) per day was identified for a considerable decrease in the platelet count. For hexaCNs in food, 2317 analytical results were used to estimate dietary exposures across dietary surveys and age groups. The highest exposure ranged from 0.91 to 29.8 pg/kg bw per day in general population and from 220 to 559 pg/kg bw per day for breast‐fed infants with the highest consumption of breast milk. Applying a margin of exposure (MOE) approach, the estimated MOEs for the high dietary exposures ranged from 1,700,000 to 55,000,000 for the general population and from 90,000 to 230,000 for breast‐fed infants with the highest consumption of breast milk. These MOEs are far above the minimum MOE of 2000 that does not raise a health concern. Taking account of the uncertainties affecting the assessment, the Panel concluded with at least 99% certainty that dietary exposure to hexaCNs does not raise a health concern for any of the population groups considered. Due to major limitations in the available data, no assessment was possible for genotoxic effects or for health risks of PCNs other than hexaCNs. |
| first_indexed | 2024-04-24T16:52:26Z |
| format | Article |
| id | doaj.art-b72ed45e59674ffe92e7bb806b64542b |
| institution | Directory Open Access Journal |
| issn | 1831-4732 |
| language | English |
| last_indexed | 2024-04-24T16:52:26Z |
| publishDate | 2024-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | EFSA Journal |
| spelling | doaj.art-b72ed45e59674ffe92e7bb806b64542b2024-03-29T03:10:39ZengWileyEFSA Journal1831-47322024-03-01223n/an/a10.2903/j.efsa.2024.8640Risks for animal and human health related to the presence of polychlorinated naphthalenes (PCNs) in feed and foodEFSA Panel name on Contaminants in the Food Chain (CONTAM)Dieter SchrenkMargherita BignamiLaurent BodinJames Kevin ChipmanJesús delMazoBettina Grasl‐KrauppChrister HogstrandLaurentius (Ron) HoogenboomJean‐Charles LeblancCarlo Stefano NebbiaEvangelia NtzaniAnnette PetersenSalomon SandTanja SchwerdtleChristiane VleminckxHeather WallaceJerzy FalandyszAndrew HartMartin RoseMaria AnastassiadouChantra EskesPetra GergelovaMatteo InnocentiElena RovestiBen WhittyElsa NielsenAbstract EFSA was asked for a scientific opinion on the risks for animal and human health related to the presence of polychlorinated naphthalenes (PCNs) in feed and food. The assessment focused on hexaCNs due to very limited data on other PCN congeners. For hexaCNs in feed, 217 analytical results were used to estimate dietary exposures for food‐producing and non‐food‐producing animals; however, a risk characterisation could not be performed because none of the toxicological studies allowed identification of reference points. The oral repeated dose toxicity studies performed in rats with a hexaCN mixture containing all 10 hexaCNs indicated that the critical target was the haematological system. A BMDL20 of 0.05 mg/kg body weight (bw) per day was identified for a considerable decrease in the platelet count. For hexaCNs in food, 2317 analytical results were used to estimate dietary exposures across dietary surveys and age groups. The highest exposure ranged from 0.91 to 29.8 pg/kg bw per day in general population and from 220 to 559 pg/kg bw per day for breast‐fed infants with the highest consumption of breast milk. Applying a margin of exposure (MOE) approach, the estimated MOEs for the high dietary exposures ranged from 1,700,000 to 55,000,000 for the general population and from 90,000 to 230,000 for breast‐fed infants with the highest consumption of breast milk. These MOEs are far above the minimum MOE of 2000 that does not raise a health concern. Taking account of the uncertainties affecting the assessment, the Panel concluded with at least 99% certainty that dietary exposure to hexaCNs does not raise a health concern for any of the population groups considered. Due to major limitations in the available data, no assessment was possible for genotoxic effects or for health risks of PCNs other than hexaCNs.https://doi.org/10.2903/j.efsa.2024.8640feedfoodPCNsPolychlorinated naphthalenesrisk assessment |
| spellingShingle | EFSA Panel name on Contaminants in the Food Chain (CONTAM) Dieter Schrenk Margherita Bignami Laurent Bodin James Kevin Chipman Jesús delMazo Bettina Grasl‐Kraupp Christer Hogstrand Laurentius (Ron) Hoogenboom Jean‐Charles Leblanc Carlo Stefano Nebbia Evangelia Ntzani Annette Petersen Salomon Sand Tanja Schwerdtle Christiane Vleminckx Heather Wallace Jerzy Falandysz Andrew Hart Martin Rose Maria Anastassiadou Chantra Eskes Petra Gergelova Matteo Innocenti Elena Rovesti Ben Whitty Elsa Nielsen Risks for animal and human health related to the presence of polychlorinated naphthalenes (PCNs) in feed and food EFSA Journal feed food PCNs Polychlorinated naphthalenes risk assessment |
| title | Risks for animal and human health related to the presence of polychlorinated naphthalenes (PCNs) in feed and food |
| title_full | Risks for animal and human health related to the presence of polychlorinated naphthalenes (PCNs) in feed and food |
| title_fullStr | Risks for animal and human health related to the presence of polychlorinated naphthalenes (PCNs) in feed and food |
| title_full_unstemmed | Risks for animal and human health related to the presence of polychlorinated naphthalenes (PCNs) in feed and food |
| title_short | Risks for animal and human health related to the presence of polychlorinated naphthalenes (PCNs) in feed and food |
| title_sort | risks for animal and human health related to the presence of polychlorinated naphthalenes pcns in feed and food |
| topic | feed food PCNs Polychlorinated naphthalenes risk assessment |
| url | https://doi.org/10.2903/j.efsa.2024.8640 |
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