Biomarkers in Stress Related Diseases/Disorders: Diagnostic, Prognostic, and Therapeutic Values
Various internal and external factors negatively affect the homeostatic equilibrium of organisms at the molecular to the whole-body level, inducing the so-called state of stress. Stress affects an organism's welfare status and induces energy-consuming mechanisms to combat the subsequent ill eff...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-10-01
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| Series: | Frontiers in Molecular Biosciences |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fmolb.2019.00091/full |
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| author | Kuldeep Dhama Shyma K. Latheef Maryam Dadar Hari Abdul Samad Ashok Munjal Rekha Khandia Kumaragurubaran Karthik Ruchi Tiwari Mohd. Iqbal Yatoo Prakash Bhatt Sandip Chakraborty Karam Pal Singh Hafiz M. N. Iqbal Wanpen Chaicumpa Sunil Kumar Joshi |
| author_facet | Kuldeep Dhama Shyma K. Latheef Maryam Dadar Hari Abdul Samad Ashok Munjal Rekha Khandia Kumaragurubaran Karthik Ruchi Tiwari Mohd. Iqbal Yatoo Prakash Bhatt Sandip Chakraborty Karam Pal Singh Hafiz M. N. Iqbal Wanpen Chaicumpa Sunil Kumar Joshi |
| author_sort | Kuldeep Dhama |
| collection | DOAJ |
| description | Various internal and external factors negatively affect the homeostatic equilibrium of organisms at the molecular to the whole-body level, inducing the so-called state of stress. Stress affects an organism's welfare status and induces energy-consuming mechanisms to combat the subsequent ill effects; thus, the individual may be immunocompromised, making them vulnerable to pathogens. The information presented here has been extensively reviewed, compiled, and analyzed from authenticated published resources available on Medline, PubMed, PubMed Central, Science Direct, and other scientific databases. Stress levels can be monitored by the quantitative and qualitative measurement of biomarkers. Potential markers of stress include thermal stress markers, such as heat shock proteins (HSPs), innate immune markers, such as Acute Phase Proteins (APPs), oxidative stress markers, and chemical secretions in the saliva and urine. In addition, stress biomarkers also play critical roles in the prognosis of stress-related diseases and disorders, and therapy guidance. Moreover, different components have been identified as potent mediators of cardiovascular, central nervous system, hepatic, and nephrological disorders, which can also be employed to evaluate these conditions precisely, but with stringent validation and specificity. Considerable scientific advances have been made in the detection, quantitation, and application of these biomarkers. The present review describes the current progress of identifying biomarkers, their prognostic, and therapeutic values. |
| first_indexed | 2024-12-11T21:12:38Z |
| format | Article |
| id | doaj.art-b731f026892046b398762485a5c119f7 |
| institution | Directory Open Access Journal |
| issn | 2296-889X |
| language | English |
| last_indexed | 2024-12-11T21:12:38Z |
| publishDate | 2019-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Biosciences |
| spelling | doaj.art-b731f026892046b398762485a5c119f72022-12-22T00:50:41ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2019-10-01610.3389/fmolb.2019.00091465402Biomarkers in Stress Related Diseases/Disorders: Diagnostic, Prognostic, and Therapeutic ValuesKuldeep Dhama0Shyma K. Latheef1Maryam Dadar2Hari Abdul Samad3Ashok Munjal4Rekha Khandia5Kumaragurubaran Karthik6Ruchi Tiwari7Mohd. Iqbal Yatoo8Prakash Bhatt9Sandip Chakraborty10Karam Pal Singh11Hafiz M. N. Iqbal12Wanpen Chaicumpa13Sunil Kumar Joshi14Division of Pathology, ICAR-Indian Veterinary Research Institute, Bareilly, IndiaDivision of Pathology, ICAR-Indian Veterinary Research Institute, Bareilly, IndiaRazi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization, Karaj, IranDivision of Physiology and Climatology, ICAR-Indian Veterinary Research Institute, Bareilly, IndiaDepartment of Genetics, Barkatullah University, Bhopal, IndiaDepartment of Genetics, Barkatullah University, Bhopal, IndiaCentral University Laboratory, Tamil Nadu Veterinary and Animal Sciences University, Chennai, IndiaDepartment of Veterinary Microbiology and Immunology, College of Veterinary Sciences, UP Pandit Deen Dayal Upadhayay Pashu Chikitsa Vigyan Vishwavidyalay Evum Go-Anusandhan Sansthan, Mathura, IndiaDivision of Veterinary Clinical Complex, Sher-E-Kashmir University of Agricultural Sciences and Technology of Kashmir, Srinagar, IndiaTeaching Veterinary Clinical Complex, College of Veterinary and Animal Sciences, Govind Ballabh Pant University of Agriculture and Technology, Pantnagar, IndiaDepartment of Veterinary Microbiology, College of Veterinary Sciences and Animal Husbandry, Agartala, IndiaDivision of Pathology, ICAR-Indian Veterinary Research Institute, Bareilly, India0Tecnologico de Monterrey, School of Engineering and Sciences, Monterrey, Mexico1Department of Parasitology, Faculty of Medicine, Center of Research Excellence on Therapeutic Proteins and Antibody Engineering, Siriraj Hospital, Mahidol University, Bangkok, Thailand2Division of Hematology, Oncology and Bone Marrow Transplantation, Department of Microbiology & Immunology, Department of Pediatrics, University of Miami School of Medicine, Miami, FL, United StatesVarious internal and external factors negatively affect the homeostatic equilibrium of organisms at the molecular to the whole-body level, inducing the so-called state of stress. Stress affects an organism's welfare status and induces energy-consuming mechanisms to combat the subsequent ill effects; thus, the individual may be immunocompromised, making them vulnerable to pathogens. The information presented here has been extensively reviewed, compiled, and analyzed from authenticated published resources available on Medline, PubMed, PubMed Central, Science Direct, and other scientific databases. Stress levels can be monitored by the quantitative and qualitative measurement of biomarkers. Potential markers of stress include thermal stress markers, such as heat shock proteins (HSPs), innate immune markers, such as Acute Phase Proteins (APPs), oxidative stress markers, and chemical secretions in the saliva and urine. In addition, stress biomarkers also play critical roles in the prognosis of stress-related diseases and disorders, and therapy guidance. Moreover, different components have been identified as potent mediators of cardiovascular, central nervous system, hepatic, and nephrological disorders, which can also be employed to evaluate these conditions precisely, but with stringent validation and specificity. Considerable scientific advances have been made in the detection, quantitation, and application of these biomarkers. The present review describes the current progress of identifying biomarkers, their prognostic, and therapeutic values.https://www.frontiersin.org/article/10.3389/fmolb.2019.00091/fullbiomarkersstressdiagnosisprognosistherapeutic valuesacute phase proteins |
| spellingShingle | Kuldeep Dhama Shyma K. Latheef Maryam Dadar Hari Abdul Samad Ashok Munjal Rekha Khandia Kumaragurubaran Karthik Ruchi Tiwari Mohd. Iqbal Yatoo Prakash Bhatt Sandip Chakraborty Karam Pal Singh Hafiz M. N. Iqbal Wanpen Chaicumpa Sunil Kumar Joshi Biomarkers in Stress Related Diseases/Disorders: Diagnostic, Prognostic, and Therapeutic Values Frontiers in Molecular Biosciences biomarkers stress diagnosis prognosis therapeutic values acute phase proteins |
| title | Biomarkers in Stress Related Diseases/Disorders: Diagnostic, Prognostic, and Therapeutic Values |
| title_full | Biomarkers in Stress Related Diseases/Disorders: Diagnostic, Prognostic, and Therapeutic Values |
| title_fullStr | Biomarkers in Stress Related Diseases/Disorders: Diagnostic, Prognostic, and Therapeutic Values |
| title_full_unstemmed | Biomarkers in Stress Related Diseases/Disorders: Diagnostic, Prognostic, and Therapeutic Values |
| title_short | Biomarkers in Stress Related Diseases/Disorders: Diagnostic, Prognostic, and Therapeutic Values |
| title_sort | biomarkers in stress related diseases disorders diagnostic prognostic and therapeutic values |
| topic | biomarkers stress diagnosis prognosis therapeutic values acute phase proteins |
| url | https://www.frontiersin.org/article/10.3389/fmolb.2019.00091/full |
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