Effects of autologous adipose-derived regenerative stem cells administered at the time of anterior cruciate ligament reconstruction on knee function and graft healing
Purpose: To compare the healing and clinical outcomes of anterior cruciate ligament (ACL) reconstruction between patients with or without intraoperative administration of adipose-derived regenerative stem cells (ADRC). Methods: Between 2013 and 2014, the outcomes of 20 soccer players undergoing ACL...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2019-08-01
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| Series: | Journal of Orthopaedic Surgery |
| Online Access: | https://doi.org/10.1177/2309499019867580 |
| _version_ | 1818180416251625472 |
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| author | Eduard Alentorn-Geli Roberto Seijas Adrián Martínez-De la Torre Xavier Cuscó Gilbert Steinbacher Pedro Álvarez-Díaz David Barastegui Jordi Navarro José Maria Serra-Renom Betina Nishishinya Jordi Català Patricia Laiz Montserrat García-Balletbó Ramón Cugat |
| author_facet | Eduard Alentorn-Geli Roberto Seijas Adrián Martínez-De la Torre Xavier Cuscó Gilbert Steinbacher Pedro Álvarez-Díaz David Barastegui Jordi Navarro José Maria Serra-Renom Betina Nishishinya Jordi Català Patricia Laiz Montserrat García-Balletbó Ramón Cugat |
| author_sort | Eduard Alentorn-Geli |
| collection | DOAJ |
| description | Purpose: To compare the healing and clinical outcomes of anterior cruciate ligament (ACL) reconstruction between patients with or without intraoperative administration of adipose-derived regenerative stem cells (ADRC). Methods: Between 2013 and 2014, the outcomes of 20 soccer players undergoing ACL reconstruction using bone–patellar tendon–bone autograft infiltrated with ADRC at the end of the procedure were compared to a historical, matched cohort of 19 soccer players undergoing the same procedure without ADRC. Outcomes were obtained at baseline, and 6 and 12 months postop for IKDC (International Knee Documentation Committee), Lysholm, and Lequesne, and at 2, 4, 6, and 12 months postop for VAS (visual analogue scale) for pain and graft maturation to evaluate the ligamentization process (magnetic resonance imaging (MRI)-based). Results: Both groups significantly improved the IKDC ( p < 0.001 in both groups), Lysholm ( p < 0.001 in both groups), Lequesne index ( p < 0.001 in both groups), VAS for pain ( p = 0.002 for the ADRC and p < 0.001 for the control group), and MRI scores ( p < 0.001 in both groups) in the 12 months postop compared to baseline scores. However, there were no significant differences in the improvement of the outcomes between groups across time ( p > 0.05). All patients returned to sports after surgery, but 8 (40%) patients in the ADRC and 13 (68.4%) patients in the control group had lower Tegner activity score at 12 months postop. Conclusions: Patients receiving ADRC at the time of ACL reconstruction significantly improved knee function and healing/maturation of the graft at 12 months. However, this improvement was not statistically significant compared to a control group undergoing ACL reconstruction alone. |
| first_indexed | 2024-12-11T21:19:25Z |
| format | Article |
| id | doaj.art-b73284a746394df7905dec09312edf55 |
| institution | Directory Open Access Journal |
| issn | 2309-4990 |
| language | English |
| last_indexed | 2024-12-11T21:19:25Z |
| publishDate | 2019-08-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Orthopaedic Surgery |
| spelling | doaj.art-b73284a746394df7905dec09312edf552022-12-22T00:50:31ZengSAGE PublishingJournal of Orthopaedic Surgery2309-49902019-08-012710.1177/2309499019867580Effects of autologous adipose-derived regenerative stem cells administered at the time of anterior cruciate ligament reconstruction on knee function and graft healingEduard Alentorn-Geli0Roberto Seijas1Adrián Martínez-De la Torre2Xavier Cuscó3Gilbert Steinbacher4Pedro Álvarez-Díaz5David Barastegui6Jordi Navarro7José Maria Serra-Renom8Betina Nishishinya9Jordi Català10Patricia Laiz11Montserrat García-Balletbó12Ramón Cugat13 Fundación García Cugat, Barcelona, Spain Universitat Internacional de Catalunya, Barcelona, Spain Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Zurich, Switzerland Fundación García Cugat, Barcelona, Spain Fundación García Cugat, Barcelona, Spain Universitat Internacional de Catalunya, Barcelona, Spain Fundación García Cugat, Barcelona, Spain Fundación García Cugat, Barcelona, Spain Institute of Aesthetic and Plastic Surgery Dr. Serra-Renom, Hospital Quironsalud, Barcelona, Spain Fundación García Cugat, Barcelona, Spain Fundación García Cugat, Barcelona, Spain Fundación García Cugat, Barcelona, Spain Fundación García Cugat, Barcelona, Spain Fundación García Cugat, Barcelona, SpainPurpose: To compare the healing and clinical outcomes of anterior cruciate ligament (ACL) reconstruction between patients with or without intraoperative administration of adipose-derived regenerative stem cells (ADRC). Methods: Between 2013 and 2014, the outcomes of 20 soccer players undergoing ACL reconstruction using bone–patellar tendon–bone autograft infiltrated with ADRC at the end of the procedure were compared to a historical, matched cohort of 19 soccer players undergoing the same procedure without ADRC. Outcomes were obtained at baseline, and 6 and 12 months postop for IKDC (International Knee Documentation Committee), Lysholm, and Lequesne, and at 2, 4, 6, and 12 months postop for VAS (visual analogue scale) for pain and graft maturation to evaluate the ligamentization process (magnetic resonance imaging (MRI)-based). Results: Both groups significantly improved the IKDC ( p < 0.001 in both groups), Lysholm ( p < 0.001 in both groups), Lequesne index ( p < 0.001 in both groups), VAS for pain ( p = 0.002 for the ADRC and p < 0.001 for the control group), and MRI scores ( p < 0.001 in both groups) in the 12 months postop compared to baseline scores. However, there were no significant differences in the improvement of the outcomes between groups across time ( p > 0.05). All patients returned to sports after surgery, but 8 (40%) patients in the ADRC and 13 (68.4%) patients in the control group had lower Tegner activity score at 12 months postop. Conclusions: Patients receiving ADRC at the time of ACL reconstruction significantly improved knee function and healing/maturation of the graft at 12 months. However, this improvement was not statistically significant compared to a control group undergoing ACL reconstruction alone.https://doi.org/10.1177/2309499019867580 |
| spellingShingle | Eduard Alentorn-Geli Roberto Seijas Adrián Martínez-De la Torre Xavier Cuscó Gilbert Steinbacher Pedro Álvarez-Díaz David Barastegui Jordi Navarro José Maria Serra-Renom Betina Nishishinya Jordi Català Patricia Laiz Montserrat García-Balletbó Ramón Cugat Effects of autologous adipose-derived regenerative stem cells administered at the time of anterior cruciate ligament reconstruction on knee function and graft healing Journal of Orthopaedic Surgery |
| title | Effects of autologous adipose-derived regenerative stem cells administered at the time of anterior cruciate ligament reconstruction on knee function and graft healing |
| title_full | Effects of autologous adipose-derived regenerative stem cells administered at the time of anterior cruciate ligament reconstruction on knee function and graft healing |
| title_fullStr | Effects of autologous adipose-derived regenerative stem cells administered at the time of anterior cruciate ligament reconstruction on knee function and graft healing |
| title_full_unstemmed | Effects of autologous adipose-derived regenerative stem cells administered at the time of anterior cruciate ligament reconstruction on knee function and graft healing |
| title_short | Effects of autologous adipose-derived regenerative stem cells administered at the time of anterior cruciate ligament reconstruction on knee function and graft healing |
| title_sort | effects of autologous adipose derived regenerative stem cells administered at the time of anterior cruciate ligament reconstruction on knee function and graft healing |
| url | https://doi.org/10.1177/2309499019867580 |
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