The expression of vascular endothelial growth factor is affected by hypoxia inducible factor-1α in peritoneum of endometriosis mice treated with genistein
This study aimed to investigate whether the genistein is able to decrease the expressions of vascular endothelial growth factor-A (VEGF-A) and hypoxia inducible factor-1α (HIF-1α) in mouse model of endometriosis. Forty female mice (Mus musculus) were divided into eight groups (n = 5 each), including...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SpringerOpen
2016-09-01
|
| Series: | Middle East Fertility Society Journal |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S111056901530025X |
| _version_ | 1830458854887915520 |
|---|---|
| author | Sylvi Wafda Nur Amellia Yuyun Yueniwati Sutrisno Sutrisno |
| author_facet | Sylvi Wafda Nur Amellia Yuyun Yueniwati Sutrisno Sutrisno |
| author_sort | Sylvi Wafda Nur Amellia |
| collection | DOAJ |
| description | This study aimed to investigate whether the genistein is able to decrease the expressions of vascular endothelial growth factor-A (VEGF-A) and hypoxia inducible factor-1α (HIF-1α) in mouse model of endometriosis. Forty female mice (Mus musculus) were divided into eight groups (n = 5 each), including the control (untreated) group, endometriosis group, and endometriosis groups treated with various doses of genistein (50; 100; 200; 300; 400; and 500 mg/day). VEGF-A and HIF-1α analyses were performed by immunohistochemistry. We found significant increases in the VEGF-A and HIF-α expressions in endometriosis group compared to the control group. The increased expressions of VEGF-A and HIF-1α were significantly (p < 0.05) attenuated by the administration of all doses of genistein. In conclusion, in mouse model of endometriosis, genistein potentially inhibits the increase in angiogenesis in peritoneal tissue. Therefore, this result may provide a novel anti-angiogenic treatment strategy for the therapy of endometriosis. |
| first_indexed | 2024-12-21T10:46:44Z |
| format | Article |
| id | doaj.art-b734902e93f74ee6b5157229e733fe07 |
| institution | Directory Open Access Journal |
| issn | 1110-5690 |
| language | English |
| last_indexed | 2024-12-21T10:46:44Z |
| publishDate | 2016-09-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Middle East Fertility Society Journal |
| spelling | doaj.art-b734902e93f74ee6b5157229e733fe072022-12-21T19:06:47ZengSpringerOpenMiddle East Fertility Society Journal1110-56902016-09-0121318018310.1016/j.mefs.2015.12.005The expression of vascular endothelial growth factor is affected by hypoxia inducible factor-1α in peritoneum of endometriosis mice treated with genisteinSylvi Wafda Nur Amellia0Yuyun Yueniwati1Sutrisno Sutrisno2Midwifery Master Study Programme, Faculty of Medicine, Brawijaya University, Malang, East Java, IndonesiaDepartment of Radiology, Saiful Anwar General Hospital, Faculty of Medicine, Brawijaya University, Malang, East Java, IndonesiaDivision of Fertility, Endocrinology and Reproduction, Department of Obstetric and Ginaecology, Saiful Anwar General Hospital, Faculty of Medicine, Brawijaya University, Malang, East Java, IndonesiaThis study aimed to investigate whether the genistein is able to decrease the expressions of vascular endothelial growth factor-A (VEGF-A) and hypoxia inducible factor-1α (HIF-1α) in mouse model of endometriosis. Forty female mice (Mus musculus) were divided into eight groups (n = 5 each), including the control (untreated) group, endometriosis group, and endometriosis groups treated with various doses of genistein (50; 100; 200; 300; 400; and 500 mg/day). VEGF-A and HIF-1α analyses were performed by immunohistochemistry. We found significant increases in the VEGF-A and HIF-α expressions in endometriosis group compared to the control group. The increased expressions of VEGF-A and HIF-1α were significantly (p < 0.05) attenuated by the administration of all doses of genistein. In conclusion, in mouse model of endometriosis, genistein potentially inhibits the increase in angiogenesis in peritoneal tissue. Therefore, this result may provide a novel anti-angiogenic treatment strategy for the therapy of endometriosis.http://www.sciencedirect.com/science/article/pii/S111056901530025XHypoxiaGrowth factorAngiogenesisPeritonealEndometriosis |
| spellingShingle | Sylvi Wafda Nur Amellia Yuyun Yueniwati Sutrisno Sutrisno The expression of vascular endothelial growth factor is affected by hypoxia inducible factor-1α in peritoneum of endometriosis mice treated with genistein Middle East Fertility Society Journal Hypoxia Growth factor Angiogenesis Peritoneal Endometriosis |
| title | The expression of vascular endothelial growth factor is affected by hypoxia inducible factor-1α in peritoneum of endometriosis mice treated with genistein |
| title_full | The expression of vascular endothelial growth factor is affected by hypoxia inducible factor-1α in peritoneum of endometriosis mice treated with genistein |
| title_fullStr | The expression of vascular endothelial growth factor is affected by hypoxia inducible factor-1α in peritoneum of endometriosis mice treated with genistein |
| title_full_unstemmed | The expression of vascular endothelial growth factor is affected by hypoxia inducible factor-1α in peritoneum of endometriosis mice treated with genistein |
| title_short | The expression of vascular endothelial growth factor is affected by hypoxia inducible factor-1α in peritoneum of endometriosis mice treated with genistein |
| title_sort | expression of vascular endothelial growth factor is affected by hypoxia inducible factor 1α in peritoneum of endometriosis mice treated with genistein |
| topic | Hypoxia Growth factor Angiogenesis Peritoneal Endometriosis |
| url | http://www.sciencedirect.com/science/article/pii/S111056901530025X |
| work_keys_str_mv | AT sylviwafdanuramellia theexpressionofvascularendothelialgrowthfactorisaffectedbyhypoxiainduciblefactor1ainperitoneumofendometriosismicetreatedwithgenistein AT yuyunyueniwati theexpressionofvascularendothelialgrowthfactorisaffectedbyhypoxiainduciblefactor1ainperitoneumofendometriosismicetreatedwithgenistein AT sutrisnosutrisno theexpressionofvascularendothelialgrowthfactorisaffectedbyhypoxiainduciblefactor1ainperitoneumofendometriosismicetreatedwithgenistein AT sylviwafdanuramellia expressionofvascularendothelialgrowthfactorisaffectedbyhypoxiainduciblefactor1ainperitoneumofendometriosismicetreatedwithgenistein AT yuyunyueniwati expressionofvascularendothelialgrowthfactorisaffectedbyhypoxiainduciblefactor1ainperitoneumofendometriosismicetreatedwithgenistein AT sutrisnosutrisno expressionofvascularendothelialgrowthfactorisaffectedbyhypoxiainduciblefactor1ainperitoneumofendometriosismicetreatedwithgenistein |