Human COQ10A and COQ10B are distinct lipid-binding START domain proteins required for coenzyme Q function[S]

Human COQ10A and COQ10B are distinct lipid-binding START domain proteins required for coenzyme Q function[S]

Coenzyme Q (CoQ or ubiquinone) serves as an essential redox-active lipid in respiratory electron and proton transport during cellular energy metabolism. CoQ also functions as a membrane-localized antioxidant protecting cells against lipid peroxidation. CoQ deficiency is associated with multiple huma...

Full description

Bibliographic Details
Main Authors:	Hui S. Tsui, NguyenV.B. Pham, Brendan R. Amer, Michelle C. Bradley, Jason E. Gosschalk, Marcus Gallagher-Jones, Hope Ibarra, Robert T. Clubb, Crysten E. Blaby-Haas, Catherine F. Clarke
Format:	Article
Language:	English
Published:	Elsevier 2019-07-01
Series:	Journal of Lipid Research
Subjects:	antioxidants lipids/chemistry lipids/peroxidation mass spectrometry mitochondria Saccharomyces cerevisiae
Online Access:	http://www.sciencedirect.com/science/article/pii/S0022227520310610

Similar Items

Human COQ9 Rescues a coq9 Yeast Mutant by Enhancing Coenzyme Q Biosynthesis from 4-Hydroxybenzoic Acid and Stabilizing the CoQ-Synthome
by: Cuiwen H. He, et al.
Published: (2017-07-01)

UBIAD1 and CoQ10 protect melanoma cells from lipid peroxidation-mediated cell death
by: Liaisan Arslanbaeva, et al.
Published: (2022-05-01)

CoQ10 and Aging
by: Isabella Peixoto de Barcelos, et al.
Published: (2019-05-01)

Primary coenzyme Q10 deficiency due to COQ8A gene mutations
by: Linwei Zhang, et al.
Published: (2020-10-01)

A fatal case of COQ7‐associated primary coenzyme Q10 deficiency
by: Anna K.‐Y. Kwong, et al.
Published: (2019-05-01)

Sets in Coq, Coq in Sets
by: Bruno Barras
Published: (2010-01-01)

Effects of coenzyme Q10 on the antioxidant system in SD rats exposed to lipopolysaccharide-induced toxicity
by: Min-Hae Song, et al.
Published: (2017-12-01)

Coenzyme Q10 Phytosome Formulation Improves CoQ10 Bioavailability and Mitochondrial Functionality in Cultured Cells
by: Nicola Rizzardi, et al.
Published: (2021-06-01)

The Effects of Coenzyme Q10 (CoQ10) on Ionizing Radiation- Induced Pancreatic β-Cell Injury
by: Filiz Mercantepe, et al.
Published: (2023-07-01)

Modeling human Coenzyme A synthase mutation in yeast reveals altered mitochondrial function, lipid content and iron metabolism
by: Camilla Ceccatelli Berti, et al.
Published: (2015-04-01)

Functional Characterization of Yiro10w (DSN1) and Yor228c Genes in Saccharomyces Cerevisiae
by: Yiap, Beow Chin
Published: (2004)

Beneficial Effects of Cornelian Cherries on Lipid Profile and NO/ROS Balance in Obese Zucker Rats: Comparison with CoQ10
by: Ezgi Dayar, et al.
Published: (2020-04-01)

Encephalopathy, kidney failure and retinopathy. CoQ10 deficiency due to COQ8B mutation
by: Victor Adam Lancet, et al.
Published: (2021-06-01)

Lipid droplet levels vary heterogeneously in response to simulated gastrointestinal stresses in different probiotic Saccharomyces cerevisiae strains
by: Daniel Zamith-Miranda, et al.
Published: (2016-03-01)

Lipid droplets formation and their effects on phosphatidylinositol level in yeasts
by: Fabrice Mutijima, et al.
Published: (2020-08-01)

Lipid accumulation from glucose and xylose in an engineered, naturally oleaginous strain of Saccharomyces cerevisiae
by: Eric Knoshaug, et al.
Published: (2018-06-01)

Studying Lipid-Related Pathophysiology Using the Yeast Model
by: Tyler Ralph-Epps, et al.
Published: (2021-10-01)

The clinical heterogeneity of coenzyme Q10 deficiency results from genotypic differences in the Coq9 gene
by: Marta Luna‐Sánchez, et al.
Published: (2015-05-01)

Exploración del efecto protector frente a radicales libres de derivados de la uva (Vitis vinifera L. Cv. Tannat) en Saccharomyces cerevisiae Analysis of a putative protection against free radicals by grape derivatives (Vitis vinifera L. Cv. Tannat) in Saccharomyces cerevisiae
by: N. Bracesco, et al.
Published: (2007-03-01)

Changes in CoQ<sub>10</sub>/Lipids Ratio, Oxidative Stress, and Coenzyme Q<sub>10</sub> during First-Line Cisplatin-Based Chemotherapy in Patients with Metastatic Urothelial Carcinoma (mUC)
by: Patrik Palacka, et al.
Published: (2022-10-01)

CoQ10'nin solunum zincirindeki etkisi
by: Başar Altınterim
Published: (2013-06-01)

Stroke-Like episodes and epilepsy in a patient with COQ8A-Related coenzyme Q10 deficiency
by: Rithvik Ramesh, et al.
Published: (2023-01-01)

Novel recessive mutations in COQ4 cause severe infantile cardiomyopathy and encephalopathy associated with CoQ10 deficiency
by: Neal Sondheimer, et al.
Published: (2017-09-01)

Perilipin 3 promotes the formation of membrane domains enriched in diacylglycerol and lipid droplet biogenesis proteins
by: Rasha Khaddaj, et al.
Published: (2023-07-01)

Possible accumulation of non-active molecules of catalase and superoxide dismutase in S. cerevisiae cells under hydrogen peroxide induced stress
by: Bayliak Maria, et al.
Published: (2007-09-01)

Treatment of CoQ(10) deficient fibroblasts with ubiquinone, CoQ analogs, and vitamin C: time- and compound-dependent effects.
by: Luis C López, et al.
Published: (2010-07-01)

Levels of Coenzyme Q<sub>10</sub> and Several COQ Proteins in Human Astrocytoma Tissues Are Inversely Correlated with Malignancy
by: Hsiu-Chuan Yen, et al.
Published: (2022-02-01)

Primary Coenzyme Q10 Deficiency-7 and Pathogenic COQ4 Variants: Clinical Presentation, Biochemical Analyses, and Treatment
by: Jieqiong Xie, et al.
Published: (2022-01-01)

A Family Segregating Lethal Primary Coenzyme Q10 Deficiency Due to Two Novel COQ6 Variants
by: Na Wang, et al.
Published: (2022-01-01)

The Important Role of CoQ<sub>10</sub> in Aging
by: Guillermo López-Lluch
Published: (2019-11-01)

CoqIOA : a formalization of IO automata in the Coq proof assistant
by: Athalye, Anish (Anish R.)
Published: (2017)

CoQ<sub>10</sub> Deficient Endothelial Cell Culture Model for the Investigation of CoQ<sub>10</sub> Blood–Brain Barrier Transport
by: Luke Wainwright, et al.
Published: (2020-10-01)

An Overview on Topical Administration of Carotenoids and Coenzyme Q10 Loaded in Lipid Nanoparticles
by: Luciana de Souza Guedes, et al.
Published: (2021-06-01)

Co-production of polyhydroxybutyrate (PHB) and coenzyme Q10 (CoQ10) via no-sugar fermentation—a case by Methylobacterium sp. XJLW
by: Peiwu Cui, et al.
Published: (2021-05-01)

Pathways shaping the mitochondrial inner membrane
by: Till Klecker, et al.
Published: (2021-12-01)

Le coq médiéval
by: Michel Pastoureau
Published: (2017-12-01)

Liposome/gold hybrid nanoparticle encoded with CoQ10 (LGNP-CoQ10) suppressed rheumatoid arthritis via STAT3/Th17 targeting.
by: Jooyeon Jhun, et al.
Published: (2020-01-01)

mSphere of Influence: Start with an Interesting Biological Phenomenon
by: Teresa O’Meara
Published: (2019-06-01)

P360: Phenotypic and molecular characterization of a cohort of patients with primary CoQ10 deficiency caused by pathogenic variants in COQ7
by: Parith Wongkittichote, et al.
Published: (2023-01-01)

CoQ<sub>10</sub> and Mitochondrial Dysfunction in Alzheimer’s Disease
by: Zdeněk Fišar, et al.
Published: (2024-02-01)