Low prevalence of anti-SSA (anti-Ro) and anti-SSB (anti-La) autoantibodies in female patients with rheumatoid arthritis with a wish to conceive
Objectives Guidelines advise to test for anti–Sjögren's-syndrome-related antigen A (anti-SSA) and anti–Sjögren's-syndrome-related antigen B (anti-SSB) antibodies in all patients with rheumatoid arthritis (RA) who wish to conceive. Our objective was to determine the prevalence and titres of...
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2021-08-01
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| Series: | RMD Open |
| Online Access: | https://rmdopen.bmj.com/content/7/2/e001727.full |
| _version_ | 1818691849414508544 |
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| author | Nathalie Costedoat-Chalumeau Radboud J E M Dolhain Jérôme M J Cornette Hieronymus T W Smeele Marco W J Schreurs |
| author_facet | Nathalie Costedoat-Chalumeau Radboud J E M Dolhain Jérôme M J Cornette Hieronymus T W Smeele Marco W J Schreurs |
| author_sort | Nathalie Costedoat-Chalumeau |
| collection | DOAJ |
| description | Objectives Guidelines advise to test for anti–Sjögren's-syndrome-related antigen A (anti-SSA) and anti–Sjögren's-syndrome-related antigen B (anti-SSB) antibodies in all patients with rheumatoid arthritis (RA) who wish to conceive. Our objective was to determine the prevalence and titres of anti-SSA and anti-SSB autoantibodies in patients with RA with a wish to conceive or pregnant.Methods Patients were derived from two large cohorts on RA and pregnancy (PARA cohort and PreCARA cohort). In addition, to determine the clinical relevance of searching for anti-SSA and anti-SSB in patients with RA, we studied the prevalence of the maternal diagnosis of RA in the French national registry of neonatal lupus syndrome (NLS) and congenital heart block (CHB).Results 26 out of 647 patients with RA had detectable anti-SSA and/or anti-SSB. Anti-SSA was detected in 25 out of 647 patients (3.9%) (Ro-52, n=17; Ro-60, n=19), anti-SSB in 7 out of 647 (1.1%). Thirteen women had a titre of >240 units/mL of anti-SSA antibodies. The prevalence of anti-SSA and/or anti-SSB was higher in rheumatoid factor (RF)-positive patients compared with RF-negative patients (5.1% vs 1.6%, p=0.04). No cases of CHB and/or NLS in the offspring were observed. In the French national register, the prevalence of RA in mothers with SSA related CHB was 1.5%.Conclusion Anti-SSA and anti-SSB have a low prevalence in patients with RA who wish to conceive. Especially for RF-negative patients, the current advise to test for anti-SSA and anti-SSB should be reconsidered. |
| first_indexed | 2024-12-17T12:48:26Z |
| format | Article |
| id | doaj.art-b735012f8662479bad8d9d6b0709e5dd |
| institution | Directory Open Access Journal |
| issn | 2056-5933 |
| language | English |
| last_indexed | 2024-12-17T12:48:26Z |
| publishDate | 2021-08-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | RMD Open |
| spelling | doaj.art-b735012f8662479bad8d9d6b0709e5dd2022-12-21T21:47:40ZengBMJ Publishing GroupRMD Open2056-59332021-08-017210.1136/rmdopen-2021-001727Low prevalence of anti-SSA (anti-Ro) and anti-SSB (anti-La) autoantibodies in female patients with rheumatoid arthritis with a wish to conceiveNathalie Costedoat-Chalumeau0Radboud J E M Dolhain1Jérôme M J Cornette2Hieronymus T W Smeele3Marco W J Schreurs4Hôpital Cochin, Centre de Référence Maladies Auto-immunes et Systémiques Rares, Paris, FranceRheumatology, Erasmus Medical Center, Rotterdam, The NetherlandsDepartment of Obstetrics and Fetal medicine, Erasmus Medical Center, Rotterdam, The NetherlandsRheumatology, Erasmus Medical Center, Rotterdam, The NetherlandsDepartment of Immunology, Erasmus Medical Center, Rotterdam, The NetherlandsObjectives Guidelines advise to test for anti–Sjögren's-syndrome-related antigen A (anti-SSA) and anti–Sjögren's-syndrome-related antigen B (anti-SSB) antibodies in all patients with rheumatoid arthritis (RA) who wish to conceive. Our objective was to determine the prevalence and titres of anti-SSA and anti-SSB autoantibodies in patients with RA with a wish to conceive or pregnant.Methods Patients were derived from two large cohorts on RA and pregnancy (PARA cohort and PreCARA cohort). In addition, to determine the clinical relevance of searching for anti-SSA and anti-SSB in patients with RA, we studied the prevalence of the maternal diagnosis of RA in the French national registry of neonatal lupus syndrome (NLS) and congenital heart block (CHB).Results 26 out of 647 patients with RA had detectable anti-SSA and/or anti-SSB. Anti-SSA was detected in 25 out of 647 patients (3.9%) (Ro-52, n=17; Ro-60, n=19), anti-SSB in 7 out of 647 (1.1%). Thirteen women had a titre of >240 units/mL of anti-SSA antibodies. The prevalence of anti-SSA and/or anti-SSB was higher in rheumatoid factor (RF)-positive patients compared with RF-negative patients (5.1% vs 1.6%, p=0.04). No cases of CHB and/or NLS in the offspring were observed. In the French national register, the prevalence of RA in mothers with SSA related CHB was 1.5%.Conclusion Anti-SSA and anti-SSB have a low prevalence in patients with RA who wish to conceive. Especially for RF-negative patients, the current advise to test for anti-SSA and anti-SSB should be reconsidered.https://rmdopen.bmj.com/content/7/2/e001727.full |
| spellingShingle | Nathalie Costedoat-Chalumeau Radboud J E M Dolhain Jérôme M J Cornette Hieronymus T W Smeele Marco W J Schreurs Low prevalence of anti-SSA (anti-Ro) and anti-SSB (anti-La) autoantibodies in female patients with rheumatoid arthritis with a wish to conceive RMD Open |
| title | Low prevalence of anti-SSA (anti-Ro) and anti-SSB (anti-La) autoantibodies in female patients with rheumatoid arthritis with a wish to conceive |
| title_full | Low prevalence of anti-SSA (anti-Ro) and anti-SSB (anti-La) autoantibodies in female patients with rheumatoid arthritis with a wish to conceive |
| title_fullStr | Low prevalence of anti-SSA (anti-Ro) and anti-SSB (anti-La) autoantibodies in female patients with rheumatoid arthritis with a wish to conceive |
| title_full_unstemmed | Low prevalence of anti-SSA (anti-Ro) and anti-SSB (anti-La) autoantibodies in female patients with rheumatoid arthritis with a wish to conceive |
| title_short | Low prevalence of anti-SSA (anti-Ro) and anti-SSB (anti-La) autoantibodies in female patients with rheumatoid arthritis with a wish to conceive |
| title_sort | low prevalence of anti ssa anti ro and anti ssb anti la autoantibodies in female patients with rheumatoid arthritis with a wish to conceive |
| url | https://rmdopen.bmj.com/content/7/2/e001727.full |
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