Prevalence of phenotypic resistance of Staphylococcus aureus isolates to macrolide, lincosamide, streptogramin B, ketolid and linezolid antibiotics in Turkey
The incidence of drug-resistant pathogens differs greatly between countries according to differences in the usage of antibiotics. The purpose of this study was to investigate the phenotypic resistance of 321 methicillin resistance Staphylococcus aureus (MRSA) and 195 methicillin susceptible S. aureu...
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Elsevier
2010-01-01
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| Series: | Brazilian Journal of Infectious Diseases |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1413867010700039 |
| _version_ | 1818145627100413952 |
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| author | Riza Adaleti Yasar Nakipoglu Nurgul Ceran Cihan Tasdemir Fatma Kaya Semiha Tasdemir |
| author_facet | Riza Adaleti Yasar Nakipoglu Nurgul Ceran Cihan Tasdemir Fatma Kaya Semiha Tasdemir |
| author_sort | Riza Adaleti |
| collection | DOAJ |
| description | The incidence of drug-resistant pathogens differs greatly between countries according to differences in the usage of antibiotics. The purpose of this study was to investigate the phenotypic resistance of 321 methicillin resistance Staphylococcus aureus (MRSA) and 195 methicillin susceptible S. aureus (MSSA) in a total of 516 S. aureus strains to macrolide, lincosamide, streptogramin B (MLSB), ketolid, and linezolid. Disk diffusion method was applied to determine MLSB phenotype and susceptibility to different antibiotic agents. It was found that 54.6% of the isolates were resistant to erythromycin (ERSA), 48% to clindamycin, 55% to azithromycin, 58.7% to spiramycin, 34.7% to telithromycin, and 0.4% to quinupristin-dalfopristin, respectively. No strain resistant to linezolid was found. The prevalence of constitutive (cMLSB), inducible (IMLSB), and macrolides and type B streptogramins (M/MSB) among ERSA isolates (237 MRSA, 45 MSSA) was 69.6%, 18.2%, and 12.2% in MRSA and 28.9%, 40%, and 31.1% in MSSA, respectively. In conclusions, the prevalence of cMLSB was predominant in MRSA; while in MSSA strains, iMLSB and M/MSB phenotype were more higher than cMLSB phenotype resistance. The resistance to quinupristindalfopristin was very low, and linezolid was considered as the most effective antibiotic against all S.aureus strains. Keywords: Staphylococcus aureus, macrolide, lincosamide, streptogramin B, ketolid, linezolid, MLSB |
| first_indexed | 2024-12-11T12:06:28Z |
| format | Article |
| id | doaj.art-b7355dbf20f043ad8122c687fa02affc |
| institution | Directory Open Access Journal |
| issn | 1413-8670 |
| language | English |
| last_indexed | 2024-12-11T12:06:28Z |
| publishDate | 2010-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brazilian Journal of Infectious Diseases |
| spelling | doaj.art-b7355dbf20f043ad8122c687fa02affc2022-12-22T01:07:56ZengElsevierBrazilian Journal of Infectious Diseases1413-86702010-01-011411114Prevalence of phenotypic resistance of Staphylococcus aureus isolates to macrolide, lincosamide, streptogramin B, ketolid and linezolid antibiotics in TurkeyRiza Adaleti0Yasar Nakipoglu1Nurgul Ceran2Cihan Tasdemir3Fatma Kaya4Semiha Tasdemir5Clinical Microbiology Laboratory, Haydarpasa Numune Education and Research Hospital, Istanbul, TurkeyIstanbul University, Istanbul Faculty of Medicine, Department of Microbiology and Clinical Microbiology, 34390 Capa, Istanbul, Turkey; Correspondence to: Department of Microbiology and Clinical Microbiology Istanbul Faculty of Medicine Istanbul University 34390 Capa Istanbul, Turkey. Tel: +90 212 414 20 00-32372, Fax: +90 212 414 20 37.Clinical Microbiology and infectious disease, Haydarpasa Numune Education and Research Hospital, Istanbul, TurkeyClinical Microbiology Laboratory, Haydarpasa Numune Education and Research Hospital, Istanbul, TurkeyClinical Microbiology Laboratory, Haydarpasa Numune Education and Research Hospital, Istanbul, TurkeyClinical Microbiology Laboratory, Haydarpasa Numune Education and Research Hospital, Istanbul, TurkeyThe incidence of drug-resistant pathogens differs greatly between countries according to differences in the usage of antibiotics. The purpose of this study was to investigate the phenotypic resistance of 321 methicillin resistance Staphylococcus aureus (MRSA) and 195 methicillin susceptible S. aureus (MSSA) in a total of 516 S. aureus strains to macrolide, lincosamide, streptogramin B (MLSB), ketolid, and linezolid. Disk diffusion method was applied to determine MLSB phenotype and susceptibility to different antibiotic agents. It was found that 54.6% of the isolates were resistant to erythromycin (ERSA), 48% to clindamycin, 55% to azithromycin, 58.7% to spiramycin, 34.7% to telithromycin, and 0.4% to quinupristin-dalfopristin, respectively. No strain resistant to linezolid was found. The prevalence of constitutive (cMLSB), inducible (IMLSB), and macrolides and type B streptogramins (M/MSB) among ERSA isolates (237 MRSA, 45 MSSA) was 69.6%, 18.2%, and 12.2% in MRSA and 28.9%, 40%, and 31.1% in MSSA, respectively. In conclusions, the prevalence of cMLSB was predominant in MRSA; while in MSSA strains, iMLSB and M/MSB phenotype were more higher than cMLSB phenotype resistance. The resistance to quinupristindalfopristin was very low, and linezolid was considered as the most effective antibiotic against all S.aureus strains. Keywords: Staphylococcus aureus, macrolide, lincosamide, streptogramin B, ketolid, linezolid, MLSBhttp://www.sciencedirect.com/science/article/pii/S1413867010700039 |
| spellingShingle | Riza Adaleti Yasar Nakipoglu Nurgul Ceran Cihan Tasdemir Fatma Kaya Semiha Tasdemir Prevalence of phenotypic resistance of Staphylococcus aureus isolates to macrolide, lincosamide, streptogramin B, ketolid and linezolid antibiotics in Turkey Brazilian Journal of Infectious Diseases |
| title | Prevalence of phenotypic resistance of Staphylococcus aureus isolates to macrolide, lincosamide, streptogramin B, ketolid and linezolid antibiotics in Turkey |
| title_full | Prevalence of phenotypic resistance of Staphylococcus aureus isolates to macrolide, lincosamide, streptogramin B, ketolid and linezolid antibiotics in Turkey |
| title_fullStr | Prevalence of phenotypic resistance of Staphylococcus aureus isolates to macrolide, lincosamide, streptogramin B, ketolid and linezolid antibiotics in Turkey |
| title_full_unstemmed | Prevalence of phenotypic resistance of Staphylococcus aureus isolates to macrolide, lincosamide, streptogramin B, ketolid and linezolid antibiotics in Turkey |
| title_short | Prevalence of phenotypic resistance of Staphylococcus aureus isolates to macrolide, lincosamide, streptogramin B, ketolid and linezolid antibiotics in Turkey |
| title_sort | prevalence of phenotypic resistance of staphylococcus aureus isolates to macrolide lincosamide streptogramin b ketolid and linezolid antibiotics in turkey |
| url | http://www.sciencedirect.com/science/article/pii/S1413867010700039 |
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