Flow cytometry detection of cell type-specific expression of programmed death receptor ligand-1 (PD-L1) in colorectal cancer specimens

Flow cytometry detection of cell type-specific expression of programmed death receptor ligand-1 (PD-L1) in colorectal cancer specimens

Aim: PD-1/PD-L1 blockade therapy is now widely used for the treatment of advanced malignancies. Although PD-L1 is known to be expressed by various host cells as well as tumor cells, the role of PD-L1 on non-malignant cells and its clinical significance is unknown. We evaluated cell type-specific exp...

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Bibliographic Details
Main Authors: Akira Saito, Mineyuki Tojo, Yuko Kumagai, Hideyuki Ohzawa, Hironori Yamaguchi, Hideyo Miyato, Ai Sadatomo, Daishi Naoi, Gaku Ota, Koji Koinuma, Hisanaga Horie, Alan Kawarai Lefor, Naohiro Sata, Joji Kitayama
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Heliyon
Subjects:
Colorectal cancer
Flow cytometry
PD-L1
CD326 (EpCAM)
Epithelial mesenchymal transition (EMT)
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844020327225

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