Challenges in Quantifying Cytosine Methylation in the HIV Provirus

Challenges in Quantifying Cytosine Methylation in the HIV Provirus

ABSTRACT DNA methylation is an epigenetic mechanism most commonly associated with transcriptional repression. While it is clear that DNA methylation can silence HIV proviral expression in in vitro latency models, its correlation with HIV persistence and expression in vivo is ambiguous, particularly...

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Bibliographic Details
Main Authors: Sarah A. LaMere, Antoine Chaillon, Christina Huynh, Davey M. Smith, Sara Gianella
Format: Article
Language:English
Published: American Society for Microbiology 2019-02-01
Series:mBio
Subjects:
HIV latency
cytosine methylation
epigenetic silencing
non-CpG methylation
Online Access:https://journals.asm.org/doi/10.1128/mBio.02268-18

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