Relevance of <i>HOTAIR</i> rs920778 and rs12826786 Genetic Variants in Bladder Cancer Risk and Survival
The long non-coding RNA HOX transcript antisense intergenic RNA (<i>HOTAIR</i>) is associated with oncogenic features in bladder cancer and is predictive of poor clinical outcomes in patients diagnosed with this disease. In this study, we evaluated the impact of the <i>HOTAIR</i...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-01-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/16/2/434 |
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| author | Eduarda P. Martins Joana Vieira de Castro Rita Fontes Sara Monteiro-Reis Rui Henrique Carmen Jerónimo Bruno M. Costa |
| author_facet | Eduarda P. Martins Joana Vieira de Castro Rita Fontes Sara Monteiro-Reis Rui Henrique Carmen Jerónimo Bruno M. Costa |
| author_sort | Eduarda P. Martins |
| collection | DOAJ |
| description | The long non-coding RNA HOX transcript antisense intergenic RNA (<i>HOTAIR</i>) is associated with oncogenic features in bladder cancer and is predictive of poor clinical outcomes in patients diagnosed with this disease. In this study, we evaluated the impact of the <i>HOTAIR</i> single nucleotide polymorphisms rs920778 and rs12826786 on bladder cancer risk and survival. This case-control study included 106 bladder cancer patients and 199 cancer-free controls. Polymorphisms were evaluated through PCR-restriction fragment length polymorphism. The odds ratio and 95% confidence intervals were tested using univariable and multivariable logistic regressions. The effects on patient survival were evaluated using the log-rank test and Cox regression models. Our data showed that the <i>HOTAIR</i> rs920778 and rs12826786 genetic variants are not associated with the risk of developing bladder cancer. Nevertheless, survival analyses suggested that the <i>HOTAIR</i> rs920778 TT genotype and rs12826786 CC genotype are associated with increased survival in male bladder cancer patients and in patients, both male and female, who have primary tumors with a pathological stage of pT2. Together, these results suggest that, despite not being associated with bladder cancer risk, <i>HOTAIR</i> rs920778 and rs12826786 polymorphisms might represent new prognostic factors in this type of cancer. This is particularly important as these polymorphisms might be easily evaluated in bladder cancer patients in a minimally invasive manner to better predict their clinical outcomes. |
| first_indexed | 2024-03-08T11:02:30Z |
| format | Article |
| id | doaj.art-b7394637e3404f6bb15b51fa78f1808c |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-08T11:02:30Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-b7394637e3404f6bb15b51fa78f1808c2024-01-26T15:38:36ZengMDPI AGCancers2072-66942024-01-0116243410.3390/cancers16020434Relevance of <i>HOTAIR</i> rs920778 and rs12826786 Genetic Variants in Bladder Cancer Risk and SurvivalEduarda P. Martins0Joana Vieira de Castro1Rita Fontes2Sara Monteiro-Reis3Rui Henrique4Carmen Jerónimo5Bruno M. Costa6Life and Health Sciences Research Institute (ICVS), School of Medicine, Campus de Gualtar, University of Minho, 4710-057 Braga, PortugalLife and Health Sciences Research Institute (ICVS), School of Medicine, Campus de Gualtar, University of Minho, 4710-057 Braga, PortugalLife and Health Sciences Research Institute (ICVS), School of Medicine, Campus de Gualtar, University of Minho, 4710-057 Braga, PortugalCancer Biology & Epigenetics Group, Research Center of IPO Porto (CI-IPOP), CI-IPOP @RISE (Health Research Network), Portuguese Oncology Institute of Porto (IPO Porto), Porto Comprehensive Cancer Center Raquel Seruca (Porto.CCC), 4200-072 Porto, PortugalCancer Biology & Epigenetics Group, Research Center of IPO Porto (CI-IPOP), CI-IPOP @RISE (Health Research Network), Portuguese Oncology Institute of Porto (IPO Porto), Porto Comprehensive Cancer Center Raquel Seruca (Porto.CCC), 4200-072 Porto, PortugalCancer Biology & Epigenetics Group, Research Center of IPO Porto (CI-IPOP), CI-IPOP @RISE (Health Research Network), Portuguese Oncology Institute of Porto (IPO Porto), Porto Comprehensive Cancer Center Raquel Seruca (Porto.CCC), 4200-072 Porto, PortugalLife and Health Sciences Research Institute (ICVS), School of Medicine, Campus de Gualtar, University of Minho, 4710-057 Braga, PortugalThe long non-coding RNA HOX transcript antisense intergenic RNA (<i>HOTAIR</i>) is associated with oncogenic features in bladder cancer and is predictive of poor clinical outcomes in patients diagnosed with this disease. In this study, we evaluated the impact of the <i>HOTAIR</i> single nucleotide polymorphisms rs920778 and rs12826786 on bladder cancer risk and survival. This case-control study included 106 bladder cancer patients and 199 cancer-free controls. Polymorphisms were evaluated through PCR-restriction fragment length polymorphism. The odds ratio and 95% confidence intervals were tested using univariable and multivariable logistic regressions. The effects on patient survival were evaluated using the log-rank test and Cox regression models. Our data showed that the <i>HOTAIR</i> rs920778 and rs12826786 genetic variants are not associated with the risk of developing bladder cancer. Nevertheless, survival analyses suggested that the <i>HOTAIR</i> rs920778 TT genotype and rs12826786 CC genotype are associated with increased survival in male bladder cancer patients and in patients, both male and female, who have primary tumors with a pathological stage of pT2. Together, these results suggest that, despite not being associated with bladder cancer risk, <i>HOTAIR</i> rs920778 and rs12826786 polymorphisms might represent new prognostic factors in this type of cancer. This is particularly important as these polymorphisms might be easily evaluated in bladder cancer patients in a minimally invasive manner to better predict their clinical outcomes.https://www.mdpi.com/2072-6694/16/2/434<i>HOTAIR</i>rs920778rs12826786SNPbladder cancer |
| spellingShingle | Eduarda P. Martins Joana Vieira de Castro Rita Fontes Sara Monteiro-Reis Rui Henrique Carmen Jerónimo Bruno M. Costa Relevance of <i>HOTAIR</i> rs920778 and rs12826786 Genetic Variants in Bladder Cancer Risk and Survival Cancers <i>HOTAIR</i> rs920778 rs12826786 SNP bladder cancer |
| title | Relevance of <i>HOTAIR</i> rs920778 and rs12826786 Genetic Variants in Bladder Cancer Risk and Survival |
| title_full | Relevance of <i>HOTAIR</i> rs920778 and rs12826786 Genetic Variants in Bladder Cancer Risk and Survival |
| title_fullStr | Relevance of <i>HOTAIR</i> rs920778 and rs12826786 Genetic Variants in Bladder Cancer Risk and Survival |
| title_full_unstemmed | Relevance of <i>HOTAIR</i> rs920778 and rs12826786 Genetic Variants in Bladder Cancer Risk and Survival |
| title_short | Relevance of <i>HOTAIR</i> rs920778 and rs12826786 Genetic Variants in Bladder Cancer Risk and Survival |
| title_sort | relevance of i hotair i rs920778 and rs12826786 genetic variants in bladder cancer risk and survival |
| topic | <i>HOTAIR</i> rs920778 rs12826786 SNP bladder cancer |
| url | https://www.mdpi.com/2072-6694/16/2/434 |
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