Food Restriction Reveals Individual Differences in Insulin-Like Growth Factor-1 Reaction Norms
Most organisms have to cope with unpredictable environmental challenges such as fluctuations in nutritional resources. Insulin-like growth factor-1 (IGF-1) is an evolutionarily conserved hormone that is highly sensitive to the individual nutritional status and regulates major life-history traits inc...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Ecology and Evolution |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fevo.2022.826968/full |
| _version_ | 1811209304133337088 |
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| author | Zsófia Tóth Zsófia Tóth Katharina Mahr Gyula Ölveczki Levente Őri Ádám Zoltán Lendvai |
| author_facet | Zsófia Tóth Zsófia Tóth Katharina Mahr Gyula Ölveczki Levente Őri Ádám Zoltán Lendvai |
| author_sort | Zsófia Tóth |
| collection | DOAJ |
| description | Most organisms have to cope with unpredictable environmental challenges such as fluctuations in nutritional resources. Insulin-like growth factor-1 (IGF-1) is an evolutionarily conserved hormone that is highly sensitive to the individual nutritional status and regulates major life-history traits including lifespan and reproduction across vertebrates. We investigated the role of IGF-1 during periods of food shortages by altering between two feeding regimes (110 and 70% of daily food intake) after a period of ad libitum feeding in captive bearded reedlings (Panurus biarmicus). Each dietary treatment was repeated twice. Birds lost mass under food restriction, but the magnitude of mass change depended on the preceding dietary conditions. Moreover, bearded reedlings showed large, repeatable individual differences in their IGF-1 reaction norms with some individuals increasing IGF-1 levels in response to a restricted diet, whereas others showed no responses or decreased IGF-1 levels. This variation was explained by differences in average body mass: heavier individuals had higher IGF-1 levels during the control treatment and were more likely to decrease IGF-1 levels in response to the dietary restriction than did lighter ones. This result uncovers an individual by environment interaction (I × E) and may have important implications for the evolution of IGF-1 related hormonal phenotypes in this species. |
| first_indexed | 2024-04-12T04:37:14Z |
| format | Article |
| id | doaj.art-b73946ba77db40ec843049a722c7e16a |
| institution | Directory Open Access Journal |
| issn | 2296-701X |
| language | English |
| last_indexed | 2024-04-12T04:37:14Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Ecology and Evolution |
| spelling | doaj.art-b73946ba77db40ec843049a722c7e16a2022-12-22T03:47:47ZengFrontiers Media S.A.Frontiers in Ecology and Evolution2296-701X2022-07-011010.3389/fevo.2022.826968826968Food Restriction Reveals Individual Differences in Insulin-Like Growth Factor-1 Reaction NormsZsófia Tóth0Zsófia Tóth1Katharina Mahr2Gyula Ölveczki3Levente Őri4Ádám Zoltán Lendvai5Department of Evolutionary Zoology and Human Biology, University of Debrecen, Debrecen, HungaryPál Juhász-Nagy Doctoral School of Biology and Environmental Sciences, University of Debrecen, Debrecen, HungaryDepartment of Interdisciplinary Life Sciences, Konrad Lorenz Institute of Ethology, University of Veterinary Medicine, Vienna, AustriaDepartment of Evolutionary Zoology and Human Biology, University of Debrecen, Debrecen, HungaryDepartment of Evolutionary Zoology and Human Biology, University of Debrecen, Debrecen, HungaryDepartment of Evolutionary Zoology and Human Biology, University of Debrecen, Debrecen, HungaryMost organisms have to cope with unpredictable environmental challenges such as fluctuations in nutritional resources. Insulin-like growth factor-1 (IGF-1) is an evolutionarily conserved hormone that is highly sensitive to the individual nutritional status and regulates major life-history traits including lifespan and reproduction across vertebrates. We investigated the role of IGF-1 during periods of food shortages by altering between two feeding regimes (110 and 70% of daily food intake) after a period of ad libitum feeding in captive bearded reedlings (Panurus biarmicus). Each dietary treatment was repeated twice. Birds lost mass under food restriction, but the magnitude of mass change depended on the preceding dietary conditions. Moreover, bearded reedlings showed large, repeatable individual differences in their IGF-1 reaction norms with some individuals increasing IGF-1 levels in response to a restricted diet, whereas others showed no responses or decreased IGF-1 levels. This variation was explained by differences in average body mass: heavier individuals had higher IGF-1 levels during the control treatment and were more likely to decrease IGF-1 levels in response to the dietary restriction than did lighter ones. This result uncovers an individual by environment interaction (I × E) and may have important implications for the evolution of IGF-1 related hormonal phenotypes in this species.https://www.frontiersin.org/articles/10.3389/fevo.2022.826968/fullinsulin-like growth factor-1 (IGF-1)stressPanurus biarmicusbody massendocrinologynutrition |
| spellingShingle | Zsófia Tóth Zsófia Tóth Katharina Mahr Gyula Ölveczki Levente Őri Ádám Zoltán Lendvai Food Restriction Reveals Individual Differences in Insulin-Like Growth Factor-1 Reaction Norms Frontiers in Ecology and Evolution insulin-like growth factor-1 (IGF-1) stress Panurus biarmicus body mass endocrinology nutrition |
| title | Food Restriction Reveals Individual Differences in Insulin-Like Growth Factor-1 Reaction Norms |
| title_full | Food Restriction Reveals Individual Differences in Insulin-Like Growth Factor-1 Reaction Norms |
| title_fullStr | Food Restriction Reveals Individual Differences in Insulin-Like Growth Factor-1 Reaction Norms |
| title_full_unstemmed | Food Restriction Reveals Individual Differences in Insulin-Like Growth Factor-1 Reaction Norms |
| title_short | Food Restriction Reveals Individual Differences in Insulin-Like Growth Factor-1 Reaction Norms |
| title_sort | food restriction reveals individual differences in insulin like growth factor 1 reaction norms |
| topic | insulin-like growth factor-1 (IGF-1) stress Panurus biarmicus body mass endocrinology nutrition |
| url | https://www.frontiersin.org/articles/10.3389/fevo.2022.826968/full |
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