Inhibition of synaptic transmission by anandamide precursor 20:4-NAPE is mediated by TRPV1 receptors under inflammatory conditions

Inhibition of synaptic transmission by anandamide precursor 20:4-NAPE is mediated by TRPV1 receptors under inflammatory conditions

Transient receptor potential ion channel, vanilloid subfamily, type 1 (TRPV1) cation channel, and cannabinoid receptor 1 (CB1) are essential in the modulation of nociceptive signaling in the spinal cord dorsal horn that underlies different pathological pain states. TRPV1 and CB1 receptors share the...

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Bibliographic Details
Main Authors: Diana Spicarova, Vladimir Nerandzic, David Muzik, Monica Pontearso, Anirban Bhattacharyya, Istvan Nagy, Jiri Palecek
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Molecular Neuroscience
Subjects:
20:4-NAPE
TRPV1
CB1
anandamide
NAPE-PLD
spinal cord
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2023.1188503/full

Internet

https://www.frontiersin.org/articles/10.3389/fnmol.2023.1188503/full

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