WZB117 enhanced the anti-tumor effect of apatinib against melanoma via blocking STAT3/PKM2 axis

WZB117 enhanced the anti-tumor effect of apatinib against melanoma via blocking STAT3/PKM2 axis

Background: Melanoma is the most lethal skin malignant tumor with a short survival once stepping into the metastatic status and poses a therapeutic challenge. Apatinib (a tyrosine kinase inhibitor) is a promising antiangiogenic agent for the treatment of metastatic melanoma. However, antiangiogenic...

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Bibliographic Details
Main Authors: Ren-Shu Zhang, Zhi-Ke Li, Jie Liu, Yao-Tiao Deng, Yu Jiang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Pharmacology
Subjects:
apatinib
WZB117
melanoma
glycolysis
stat3
PKM2
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.976117/full

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