Clinicopathological features and outcomes of choriocarcinoma: A retrospective analysis from an Indian tertiary cancer center
Background: Choriocarcinoma is the most common form of gestational trophoblastic neoplasia seen by medical oncologists. It is a rare condition and data related to its long-term outcomes from the Indian subcontinent are sparse. Objectives: The primary objective of this study was to assess the clinico...
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| Format: | Article |
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Wolters Kluwer Medknow Publications
2021-01-01
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| Series: | Cancer Research, Statistics, and Treatment |
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| Online Access: | http://www.crstonline.com/article.asp?issn=2590-3233;year=2021;volume=4;issue=3;spage=486;epage=491;aulast=Ghosh |
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| author | Joydeep Ghosh Sayantika Dey Debapriya Mandal Sandip Ganguly Bivas Biswas Deepak Dabkara Anik Ghosh Basumita Chakraborty Arunava Roy Shweta Rai Sonia Mathai Jaydip Bhaumik |
| author_facet | Joydeep Ghosh Sayantika Dey Debapriya Mandal Sandip Ganguly Bivas Biswas Deepak Dabkara Anik Ghosh Basumita Chakraborty Arunava Roy Shweta Rai Sonia Mathai Jaydip Bhaumik |
| author_sort | Joydeep Ghosh |
| collection | DOAJ |
| description | Background: Choriocarcinoma is the most common form of gestational trophoblastic neoplasia seen by medical oncologists. It is a rare condition and data related to its long-term outcomes from the Indian subcontinent are sparse.
Objectives: The primary objective of this study was to assess the clinicopathological characteristics and clinical outcomes of patients with of choriocarcinoma; the secondary objective was to assess the correlation of outcomes with risk stratification.
Materials and Methods: This single-center retrospective study was conducted at the Tata Medical Center, a tertiary cancer center in West Bengal, India. We identified all the cases of choriocarcinoma treated at our hospital from the electronic medical records and noted their baseline characteristics, treatment details, and clinical outcomes. Descriptive statistics were used for baseline characteristics, and the Kaplan–Meier method was used for the survival analysis.
Results: A total of 24 patients were included in the study. The median age of the patients was 29 years (interquartile range, 25.9–39.5). The median time interval from the last pregnancy was 5 months (range, 0 months to 11 years). The World Health Organization risk score was low in 8 (33.3%) and high in 16 (66.7%) patients. There were 6 (25%) patients who received single-agent chemotherapy, 14 (66.7%) received the EMA-CO (etoposide, methotrexate, actinomycin D, cyclophosphamide, and vincristine) regimen, and 1 (4.7%) received the VIP (etoposide, ifosfamide, and cisplatin) regimen, with the latter 2 being given only to high-risk patients. The median follow-up was 10.9 months (95% confidence interval [CI], 4.2–28.5). The median progression-free survival was not reached (NR) (95% CI, 7.2–NR). Similarly, the median overall survival was NR (95% CI, 10.56–NR).
Conclusion: Our study provides real-world data for this rare malignancy and reinforces the fact that choriocarcinoma is a highly curable disease. Despite the clinicopathological variations in the different parts of the country, the long-term outcomes are favorable. |
| first_indexed | 2024-12-18T23:01:02Z |
| format | Article |
| id | doaj.art-b741e091ac794f67bb72fd77020ecd53 |
| institution | Directory Open Access Journal |
| issn | 2590-3233 2590-3225 |
| language | English |
| last_indexed | 2024-12-18T23:01:02Z |
| publishDate | 2021-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Cancer Research, Statistics, and Treatment |
| spelling | doaj.art-b741e091ac794f67bb72fd77020ecd532022-12-21T20:48:36ZengWolters Kluwer Medknow PublicationsCancer Research, Statistics, and Treatment2590-32332590-32252021-01-014348649110.4103/crst.crst_124_21Clinicopathological features and outcomes of choriocarcinoma: A retrospective analysis from an Indian tertiary cancer centerJoydeep GhoshSayantika DeyDebapriya MandalSandip GangulyBivas BiswasDeepak DabkaraAnik GhoshBasumita ChakrabortyArunava RoyShweta RaiSonia MathaiJaydip BhaumikBackground: Choriocarcinoma is the most common form of gestational trophoblastic neoplasia seen by medical oncologists. It is a rare condition and data related to its long-term outcomes from the Indian subcontinent are sparse. Objectives: The primary objective of this study was to assess the clinicopathological characteristics and clinical outcomes of patients with of choriocarcinoma; the secondary objective was to assess the correlation of outcomes with risk stratification. Materials and Methods: This single-center retrospective study was conducted at the Tata Medical Center, a tertiary cancer center in West Bengal, India. We identified all the cases of choriocarcinoma treated at our hospital from the electronic medical records and noted their baseline characteristics, treatment details, and clinical outcomes. Descriptive statistics were used for baseline characteristics, and the Kaplan–Meier method was used for the survival analysis. Results: A total of 24 patients were included in the study. The median age of the patients was 29 years (interquartile range, 25.9–39.5). The median time interval from the last pregnancy was 5 months (range, 0 months to 11 years). The World Health Organization risk score was low in 8 (33.3%) and high in 16 (66.7%) patients. There were 6 (25%) patients who received single-agent chemotherapy, 14 (66.7%) received the EMA-CO (etoposide, methotrexate, actinomycin D, cyclophosphamide, and vincristine) regimen, and 1 (4.7%) received the VIP (etoposide, ifosfamide, and cisplatin) regimen, with the latter 2 being given only to high-risk patients. The median follow-up was 10.9 months (95% confidence interval [CI], 4.2–28.5). The median progression-free survival was not reached (NR) (95% CI, 7.2–NR). Similarly, the median overall survival was NR (95% CI, 10.56–NR). Conclusion: Our study provides real-world data for this rare malignancy and reinforces the fact that choriocarcinoma is a highly curable disease. Despite the clinicopathological variations in the different parts of the country, the long-term outcomes are favorable.http://www.crstonline.com/article.asp?issn=2590-3233;year=2021;volume=4;issue=3;spage=486;epage=491;aulast=Ghoshchoriocarcinomaindiaoutcomereal world |
| spellingShingle | Joydeep Ghosh Sayantika Dey Debapriya Mandal Sandip Ganguly Bivas Biswas Deepak Dabkara Anik Ghosh Basumita Chakraborty Arunava Roy Shweta Rai Sonia Mathai Jaydip Bhaumik Clinicopathological features and outcomes of choriocarcinoma: A retrospective analysis from an Indian tertiary cancer center Cancer Research, Statistics, and Treatment choriocarcinoma india outcome real world |
| title | Clinicopathological features and outcomes of choriocarcinoma: A retrospective analysis from an Indian tertiary cancer center |
| title_full | Clinicopathological features and outcomes of choriocarcinoma: A retrospective analysis from an Indian tertiary cancer center |
| title_fullStr | Clinicopathological features and outcomes of choriocarcinoma: A retrospective analysis from an Indian tertiary cancer center |
| title_full_unstemmed | Clinicopathological features and outcomes of choriocarcinoma: A retrospective analysis from an Indian tertiary cancer center |
| title_short | Clinicopathological features and outcomes of choriocarcinoma: A retrospective analysis from an Indian tertiary cancer center |
| title_sort | clinicopathological features and outcomes of choriocarcinoma a retrospective analysis from an indian tertiary cancer center |
| topic | choriocarcinoma india outcome real world |
| url | http://www.crstonline.com/article.asp?issn=2590-3233;year=2021;volume=4;issue=3;spage=486;epage=491;aulast=Ghosh |
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