Metachronous Multiple Primary Carcinoma With Acute Promyelocytic Leukemia: 2 Cases Report and Literature Review
The co-occurrence of multiple primary cancers with hematological malignancies is uncommon, and acute promyelocytic leukemia (APL) with MPC is even rarer, with only a few cases reported in the literature. Herein, we introduce the diagnosis and treatment of 2 cases of MPC complicated with APL in our h...
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.893319/full |
| _version_ | 1828334408541667328 |
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| author | Cong Wang Yamei Shen Yuxia Zhang Fahui Guo Qian Li Huahua Zhang Xueping Han Haitao Zhao Zilong Yang |
| author_facet | Cong Wang Yamei Shen Yuxia Zhang Fahui Guo Qian Li Huahua Zhang Xueping Han Haitao Zhao Zilong Yang |
| author_sort | Cong Wang |
| collection | DOAJ |
| description | The co-occurrence of multiple primary cancers with hematological malignancies is uncommon, and acute promyelocytic leukemia (APL) with MPC is even rarer, with only a few cases reported in the literature. Herein, we introduce the diagnosis and treatment of 2 cases of MPC complicated with APL in our hospital and review the relevant literature. Both patients were primary solid tumor patients and were treated with surgery and chemotherapy, and had stable disease (SD). However, more than 1 year after the primary tumor was diagnosed, clinical symptoms were found and APL was diagnosed. Both patients received standard remission-induction therapy, but unfortunately died in the short term due to hemorrhagic complications. In conclusion, treatment of hematological neoplasms, especially acute leukemia combined with multiple primary cancers, is challenging. The prognostic factors and survival analysis of MPC patients with combined APL still need further clinical research and analysis. |
| first_indexed | 2024-04-13T21:32:40Z |
| format | Article |
| id | doaj.art-b745d4ed071942389aafdbf624181f94 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-13T21:32:40Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-b745d4ed071942389aafdbf624181f942022-12-22T02:29:06ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-06-011210.3389/fonc.2022.893319893319Metachronous Multiple Primary Carcinoma With Acute Promyelocytic Leukemia: 2 Cases Report and Literature ReviewCong Wang0Yamei Shen1Yuxia Zhang2Fahui Guo3Qian Li4Huahua Zhang5Xueping Han6Haitao Zhao7Zilong Yang8Department of Hematology, Wuwei Tumor Hospital, Wuwei, ChinaWuwei Institute of Hematology, Wuwei, ChinaDepartment of Hematology, Wuwei Tumor Hospital, Wuwei, ChinaWuwei Institute of Hematology, Wuwei, ChinaDepartment of Hematology, Wuwei Tumor Hospital, Wuwei, ChinaDepartment of Hematology, Wuwei Tumor Hospital, Wuwei, ChinaWuwei Institute of Hematology, Wuwei, ChinaWuwei Institute of Hematology, Wuwei, ChinaWuwei Institute of Hematology, Wuwei, ChinaThe co-occurrence of multiple primary cancers with hematological malignancies is uncommon, and acute promyelocytic leukemia (APL) with MPC is even rarer, with only a few cases reported in the literature. Herein, we introduce the diagnosis and treatment of 2 cases of MPC complicated with APL in our hospital and review the relevant literature. Both patients were primary solid tumor patients and were treated with surgery and chemotherapy, and had stable disease (SD). However, more than 1 year after the primary tumor was diagnosed, clinical symptoms were found and APL was diagnosed. Both patients received standard remission-induction therapy, but unfortunately died in the short term due to hemorrhagic complications. In conclusion, treatment of hematological neoplasms, especially acute leukemia combined with multiple primary cancers, is challenging. The prognostic factors and survival analysis of MPC patients with combined APL still need further clinical research and analysis.https://www.frontiersin.org/articles/10.3389/fonc.2022.893319/fullleukemiapromyelocyticacutesolid tumormultiple primary carcinomasdiagnosis |
| spellingShingle | Cong Wang Yamei Shen Yuxia Zhang Fahui Guo Qian Li Huahua Zhang Xueping Han Haitao Zhao Zilong Yang Metachronous Multiple Primary Carcinoma With Acute Promyelocytic Leukemia: 2 Cases Report and Literature Review Frontiers in Oncology leukemia promyelocytic acute solid tumor multiple primary carcinomas diagnosis |
| title | Metachronous Multiple Primary Carcinoma With Acute Promyelocytic Leukemia: 2 Cases Report and Literature Review |
| title_full | Metachronous Multiple Primary Carcinoma With Acute Promyelocytic Leukemia: 2 Cases Report and Literature Review |
| title_fullStr | Metachronous Multiple Primary Carcinoma With Acute Promyelocytic Leukemia: 2 Cases Report and Literature Review |
| title_full_unstemmed | Metachronous Multiple Primary Carcinoma With Acute Promyelocytic Leukemia: 2 Cases Report and Literature Review |
| title_short | Metachronous Multiple Primary Carcinoma With Acute Promyelocytic Leukemia: 2 Cases Report and Literature Review |
| title_sort | metachronous multiple primary carcinoma with acute promyelocytic leukemia 2 cases report and literature review |
| topic | leukemia promyelocytic acute solid tumor multiple primary carcinomas diagnosis |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.893319/full |
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