Inhibition of Amyloid-Beta Production, Associated Neuroinflammation, and Histone Deacetylase 2-Mediated Epigenetic Modifications Prevent Neuropathology in Alzheimer’s Disease in vitro Model

Inhibition of Amyloid-Beta Production, Associated Neuroinflammation, and Histone Deacetylase 2-Mediated Epigenetic Modifications Prevent Neuropathology in Alzheimer’s Disease in vitro Model

Alzheimer’s disease (AD) is a growing global threat to healthcare in the aging population. In the USA alone, it is estimated that one in nine persons over the age of 65 years is living with AD. The pathology is marked by the accumulation of amyloid-beta (Aβ) deposition in the brain, which is further...

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Bibliographic Details
Main Authors: Venkata Subba Rao Atluri, Sneham Tiwari, Melisa Rodriguez, Ajeet Kaushik, Adriana Yndart, Nagesh Kolishetti, Mohan Yatham, Madhavan Nair
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Aging Neuroscience
Subjects:
amyloid-beta
Alzheimer’s disease
inflammation
withaferin A
cytokine release inhibitory drug 3
mithramycin A
Online Access:https://www.frontiersin.org/article/10.3389/fnagi.2019.00342/full

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https://www.frontiersin.org/article/10.3389/fnagi.2019.00342/full

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