Role of Serum CYFRA 21-1 in Diagnosis and Prognostic in Colorectal Liver Metastases
Shirong Li,1,* Wene Wei,1,* Zhaorong Feng,1,* Yingzhen Bian,1 Jinmiao Pan,1 Jinling Mai,1 Shufang Ning,1,2 Jinglei Huang,1 Xiangyang Gao,3,* Litu Zhang1,2,* 1Department of Research, Guangxi Medical University Cancer Hospital, Nanning, People’s Republic of Chin...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2023-07-01
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| Series: | Cancer Management and Research |
| Subjects: | |
| Online Access: | https://www.dovepress.com/role-of-serum-cyfra-21-1-in-diagnosis-and-prognostic-in-colorectal-liv-peer-reviewed-fulltext-article-CMAR |
| _version_ | 1797785602307915776 |
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| author | Li S Wei W Feng Z Bian Y Pan J Mai J Ning S Huang J Gao X Zhang L |
| author_facet | Li S Wei W Feng Z Bian Y Pan J Mai J Ning S Huang J Gao X Zhang L |
| author_sort | Li S |
| collection | DOAJ |
| description | Shirong Li,1,* Wene Wei,1,* Zhaorong Feng,1,* Yingzhen Bian,1 Jinmiao Pan,1 Jinling Mai,1 Shufang Ning,1,2 Jinglei Huang,1 Xiangyang Gao,3,* Litu Zhang1,2,* 1Department of Research, Guangxi Medical University Cancer Hospital, Nanning, People’s Republic of China; 2Department of Research, Guangxi Cancer Molecular Medicine Engineering Research Center, Nanning, People’s Republic of China; 3Health Management Institute, The Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiangyang Gao; Litu Zhang, Email 13811130808@126.com; zhanglitu@gmail.comPurpose: In current studies, the role of serum Cytokeratin-19 fragments (CYFRA 21-1) in colorectal cancer (CRC) remains unclear. This study aimed to clarify the diagnostic and prognostic value of CYFRA 21-1 in CRC.Patients and Methods: Data were collected for 196 stage I–III CRC patients and 50 colorectal liver metastases (CRLM) patients between January 2018 and December 2019. The serum CYFRA 21-1 levels were measured using the chemiluminescent particle immunoassay (CMIA) kit in all objects and common biomarkers such as CA19-9, CEA, HSP90α, and AFP were measured in all colorectal cancer patients. We investigated the association between CYFRA 21-1 level and clinicopathological features. In addition, we evaluated the ability of serum CRFRA21-1 to differentiate CRLM from CRC. To assess the potential prognostic value, we used Cox proportional hazard model for univariate or multivariate analyses.Results: Serum CYFRA 21-1 was significantly elevated in CRLM patients compared to stage I–III CRC patients (5.85 ng/mL vs 2.29 ng/mL, p < 0.001). For all CRC patients cohort, stage I–III CRC patients cohort and CRLM patients cohort, the optimal cutoff levels of CYFRA 21-1 for overall survival (OS) were 3.47 ng/mL, 2.14 ng/mL and 7.63 ng/mL, respectively, and the optimal cutoff levels for progression-free survival (PFS) were 3.47 ng/mL, 2.56 ng/mL and 7.63 ng/mL, respectively. For CRLM patients, Kaplan–Meier analysis showed that patients with high CYFRA 21-1 level had poor OS. Multivariate analysis indicated that the CYFRA 21-1 level was an independent prognostic factor for PFS in stage I–III patients. And CYFRA 21-1 levels and age were independent prognostic factors for OS and PFS in CRLM patients.Conclusion: CYFRA 21-1 can better differentiate CRLM patients from the whole CRC patients and has unique prognostic value for CRLM patients.Keywords: colorectal cancer, colorectal liver metastases, CRLM, prognosis, cytokeratin-19 fragments, CYFRA21-1, overall survival, progression-free survival |
| first_indexed | 2024-03-13T00:57:22Z |
| format | Article |
| id | doaj.art-b74914f0adb24527818f2c587ffc1dc1 |
| institution | Directory Open Access Journal |
| issn | 1179-1322 |
| language | English |
| last_indexed | 2024-03-13T00:57:22Z |
| publishDate | 2023-07-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Cancer Management and Research |
| spelling | doaj.art-b74914f0adb24527818f2c587ffc1dc12023-07-06T19:09:57ZengDove Medical PressCancer Management and Research1179-13222023-07-01Volume 1560161484954Role of Serum CYFRA 21-1 in Diagnosis and Prognostic in Colorectal Liver MetastasesLi SWei WFeng ZBian YPan JMai JNing SHuang JGao XZhang LShirong Li,1,* Wene Wei,1,* Zhaorong Feng,1,* Yingzhen Bian,1 Jinmiao Pan,1 Jinling Mai,1 Shufang Ning,1,2 Jinglei Huang,1 Xiangyang Gao,3,* Litu Zhang1,2,* 1Department of Research, Guangxi Medical University Cancer Hospital, Nanning, People’s Republic of China; 2Department of Research, Guangxi Cancer Molecular Medicine Engineering Research Center, Nanning, People’s Republic of China; 3Health Management Institute, The Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiangyang Gao; Litu Zhang, Email 13811130808@126.com; zhanglitu@gmail.comPurpose: In current studies, the role of serum Cytokeratin-19 fragments (CYFRA 21-1) in colorectal cancer (CRC) remains unclear. This study aimed to clarify the diagnostic and prognostic value of CYFRA 21-1 in CRC.Patients and Methods: Data were collected for 196 stage I–III CRC patients and 50 colorectal liver metastases (CRLM) patients between January 2018 and December 2019. The serum CYFRA 21-1 levels were measured using the chemiluminescent particle immunoassay (CMIA) kit in all objects and common biomarkers such as CA19-9, CEA, HSP90α, and AFP were measured in all colorectal cancer patients. We investigated the association between CYFRA 21-1 level and clinicopathological features. In addition, we evaluated the ability of serum CRFRA21-1 to differentiate CRLM from CRC. To assess the potential prognostic value, we used Cox proportional hazard model for univariate or multivariate analyses.Results: Serum CYFRA 21-1 was significantly elevated in CRLM patients compared to stage I–III CRC patients (5.85 ng/mL vs 2.29 ng/mL, p < 0.001). For all CRC patients cohort, stage I–III CRC patients cohort and CRLM patients cohort, the optimal cutoff levels of CYFRA 21-1 for overall survival (OS) were 3.47 ng/mL, 2.14 ng/mL and 7.63 ng/mL, respectively, and the optimal cutoff levels for progression-free survival (PFS) were 3.47 ng/mL, 2.56 ng/mL and 7.63 ng/mL, respectively. For CRLM patients, Kaplan–Meier analysis showed that patients with high CYFRA 21-1 level had poor OS. Multivariate analysis indicated that the CYFRA 21-1 level was an independent prognostic factor for PFS in stage I–III patients. And CYFRA 21-1 levels and age were independent prognostic factors for OS and PFS in CRLM patients.Conclusion: CYFRA 21-1 can better differentiate CRLM patients from the whole CRC patients and has unique prognostic value for CRLM patients.Keywords: colorectal cancer, colorectal liver metastases, CRLM, prognosis, cytokeratin-19 fragments, CYFRA21-1, overall survival, progression-free survivalhttps://www.dovepress.com/role-of-serum-cyfra-21-1-in-diagnosis-and-prognostic-in-colorectal-liv-peer-reviewed-fulltext-article-CMARcolorectal cancer;colorectal liver metastasescrlmprognosiscytokeratin-19 fragmentscyfra21-1overall survivalprogression-free survival |
| spellingShingle | Li S Wei W Feng Z Bian Y Pan J Mai J Ning S Huang J Gao X Zhang L Role of Serum CYFRA 21-1 in Diagnosis and Prognostic in Colorectal Liver Metastases Cancer Management and Research colorectal cancer;colorectal liver metastases crlm prognosis cytokeratin-19 fragments cyfra21-1 overall survival progression-free survival |
| title | Role of Serum CYFRA 21-1 in Diagnosis and Prognostic in Colorectal Liver Metastases |
| title_full | Role of Serum CYFRA 21-1 in Diagnosis and Prognostic in Colorectal Liver Metastases |
| title_fullStr | Role of Serum CYFRA 21-1 in Diagnosis and Prognostic in Colorectal Liver Metastases |
| title_full_unstemmed | Role of Serum CYFRA 21-1 in Diagnosis and Prognostic in Colorectal Liver Metastases |
| title_short | Role of Serum CYFRA 21-1 in Diagnosis and Prognostic in Colorectal Liver Metastases |
| title_sort | role of serum cyfra 21 1 in diagnosis and prognostic in colorectal liver metastases |
| topic | colorectal cancer;colorectal liver metastases crlm prognosis cytokeratin-19 fragments cyfra21-1 overall survival progression-free survival |
| url | https://www.dovepress.com/role-of-serum-cyfra-21-1-in-diagnosis-and-prognostic-in-colorectal-liv-peer-reviewed-fulltext-article-CMAR |
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