Radiofrequency ablation for lung tumors: outcomes, effects on survival, and prognostic factors
PURPOSEWe aimed to evaluate the survival benefit achieved with radiofrequency (RF) ablation of primary and metastatic lung tumors and determine significant prognostic factors for recurrence-free survival.METHODSForty-nine patients with lung cancer (10 primary and 39 metastatic) underwent computed to...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Galenos Publishing House
2016-01-01
|
| Series: | Diagnostic and Interventional Radiology |
| Online Access: |
http://www.dirjournal.org/archives/archive-detail/article-preview/radiofrequency-ablation-for-lung-tumors-outcomes-e/55583
|
| _version_ | 1797691234514370560 |
|---|---|
| author | Okan Akhan Ezgi Güler Devrim Akıncı Türkmen Çiftçi Ilgaz Çağatay Köse |
| author_facet | Okan Akhan Ezgi Güler Devrim Akıncı Türkmen Çiftçi Ilgaz Çağatay Köse |
| author_sort | Okan Akhan |
| collection | DOAJ |
| description | PURPOSEWe aimed to evaluate the survival benefit achieved with radiofrequency (RF) ablation of primary and metastatic lung tumors and determine significant prognostic factors for recurrence-free survival.METHODSForty-nine patients with lung cancer (10 primary and 39 metastatic) underwent computed tomography-guided percutaneous RF ablation between June 2005 and October 2013. A total of 112 tumors (101 metastatic and 11 primary non-small cell lung cancer) were treated with RF ablation. Tumor diameter ranged from 0.6 to 4 cm (median 1.5 cm). Effectiveness of treatment, complications, and survival were analyzed.RESULTSPrimary success rate was 79.5% and local tumor progression occurred in 23 tumors. Among tumors showing progression, 10 were re-treated with RF ablation and secondary success rate was 87.5%. One-, two-, and three-year overall survival rates of 10 patients with primary lung cancer were 100%, 86%, and 43%, respectively. One-, two-, three-, four-, and five-year overall survival rates for 39 patients with metastatic lung tumors were 90%, 73%, 59%, 55%, and 38%, respectively. One-, two-, three-, and four-year overall survival rates for 16 patients with colorectal pulmonary metastases were 94%, 80%, 68%, and 23%, respectively. Complications occurred in 30 sessions (24.6%). Pneumothorax occurred in 19 sessions with seven requiring image-guided percutaneous chest tube drainage. Tumor status (solitary or multiple) and presence of extrapulmonary metastasis at initial RF ablation were significant prognostic factors in terms of recurrence-free survival.CONCLUSIONRF ablation is a safe and effective treatment with a survival benefit for selected patients with primary and secondary lung tumors. |
| first_indexed | 2024-03-12T02:10:27Z |
| format | Article |
| id | doaj.art-b74aca220b8d4b57962aa29f582d3355 |
| institution | Directory Open Access Journal |
| issn | 1305-3825 1305-3612 |
| language | English |
| last_indexed | 2024-03-12T02:10:27Z |
| publishDate | 2016-01-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Diagnostic and Interventional Radiology |
| spelling | doaj.art-b74aca220b8d4b57962aa29f582d33552023-09-06T13:42:23ZengGalenos Publishing HouseDiagnostic and Interventional Radiology1305-38251305-36122016-01-01221657110.5152/dir.2015.1437813049054Radiofrequency ablation for lung tumors: outcomes, effects on survival, and prognostic factorsOkan Akhan0Ezgi Güler1Devrim Akıncı2Türkmen Çiftçi3Ilgaz Çağatay Köse4 Department of Radiology, Hacettepe University School of Medicine, Ankara, Turkey Department of Radiology, Hacettepe University School of Medicine, Ankara, Turkey Department of Radiology, Hacettepe University School of Medicine, Ankara, Turkey Department of Radiology, Hacettepe University School of Medicine, Ankara, Turkey Department of Radiology, Hacettepe University School of Medicine, Ankara, Turkey PURPOSEWe aimed to evaluate the survival benefit achieved with radiofrequency (RF) ablation of primary and metastatic lung tumors and determine significant prognostic factors for recurrence-free survival.METHODSForty-nine patients with lung cancer (10 primary and 39 metastatic) underwent computed tomography-guided percutaneous RF ablation between June 2005 and October 2013. A total of 112 tumors (101 metastatic and 11 primary non-small cell lung cancer) were treated with RF ablation. Tumor diameter ranged from 0.6 to 4 cm (median 1.5 cm). Effectiveness of treatment, complications, and survival were analyzed.RESULTSPrimary success rate was 79.5% and local tumor progression occurred in 23 tumors. Among tumors showing progression, 10 were re-treated with RF ablation and secondary success rate was 87.5%. One-, two-, and three-year overall survival rates of 10 patients with primary lung cancer were 100%, 86%, and 43%, respectively. One-, two-, three-, four-, and five-year overall survival rates for 39 patients with metastatic lung tumors were 90%, 73%, 59%, 55%, and 38%, respectively. One-, two-, three-, and four-year overall survival rates for 16 patients with colorectal pulmonary metastases were 94%, 80%, 68%, and 23%, respectively. Complications occurred in 30 sessions (24.6%). Pneumothorax occurred in 19 sessions with seven requiring image-guided percutaneous chest tube drainage. Tumor status (solitary or multiple) and presence of extrapulmonary metastasis at initial RF ablation were significant prognostic factors in terms of recurrence-free survival.CONCLUSIONRF ablation is a safe and effective treatment with a survival benefit for selected patients with primary and secondary lung tumors. http://www.dirjournal.org/archives/archive-detail/article-preview/radiofrequency-ablation-for-lung-tumors-outcomes-e/55583 |
| spellingShingle | Okan Akhan Ezgi Güler Devrim Akıncı Türkmen Çiftçi Ilgaz Çağatay Köse Radiofrequency ablation for lung tumors: outcomes, effects on survival, and prognostic factors Diagnostic and Interventional Radiology |
| title | Radiofrequency ablation for lung tumors: outcomes, effects on survival, and prognostic factors |
| title_full | Radiofrequency ablation for lung tumors: outcomes, effects on survival, and prognostic factors |
| title_fullStr | Radiofrequency ablation for lung tumors: outcomes, effects on survival, and prognostic factors |
| title_full_unstemmed | Radiofrequency ablation for lung tumors: outcomes, effects on survival, and prognostic factors |
| title_short | Radiofrequency ablation for lung tumors: outcomes, effects on survival, and prognostic factors |
| title_sort | radiofrequency ablation for lung tumors outcomes effects on survival and prognostic factors |
| url |
http://www.dirjournal.org/archives/archive-detail/article-preview/radiofrequency-ablation-for-lung-tumors-outcomes-e/55583
|
| work_keys_str_mv | AT okanakhan radiofrequencyablationforlungtumorsoutcomeseffectsonsurvivalandprognosticfactors AT ezgiguler radiofrequencyablationforlungtumorsoutcomeseffectsonsurvivalandprognosticfactors AT devrimakıncı radiofrequencyablationforlungtumorsoutcomeseffectsonsurvivalandprognosticfactors AT turkmenciftci radiofrequencyablationforlungtumorsoutcomeseffectsonsurvivalandprognosticfactors AT ilgazcagataykose radiofrequencyablationforlungtumorsoutcomeseffectsonsurvivalandprognosticfactors |