Microbial cell factories for bio-based biodegradable plastics production
Summary: The misuse of petroleum-based plastics has resulted in serious environmental pollution and resource wastage. Biodegradable plastics can be used as green substitutes for traditional plastics. Here, we discuss the feasibility and technical bottlenecks in developing microbial cell factories fo...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-11-01
|
| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004222017345 |
| _version_ | 1811230733135511552 |
|---|---|
| author | Xiao Han Jiongqin Liu Sen Tian Fei Tao Ping Xu |
| author_facet | Xiao Han Jiongqin Liu Sen Tian Fei Tao Ping Xu |
| author_sort | Xiao Han |
| collection | DOAJ |
| description | Summary: The misuse of petroleum-based plastics has resulted in serious environmental pollution and resource wastage. Biodegradable plastics can be used as green substitutes for traditional plastics. Here, we discuss the feasibility and technical bottlenecks in developing microbial cell factories for the production of biodegradable plastics from lignocellulosic wastes. First, we introduce the basic properties of the main biodegradable plastics on the market, including poly(lactic acid), poly(hydroxyalkanoate), and poly(butylene adipate-co-terephthalate). We then demonstrate the feasibility of synthesizing petroleum-based biodegradable plastic monomers from bio-based raw materials and propose strategies to further advance their commercial production through metabolic engineering and synthetic biology. We also analyze the main challenges facing the current development of bio-based biodegradable plastic biosynthesis technology. Finally, we discuss the current major lignocellulose bioconversion processes and explore way to further improve the utilization efficiency of the main carbohydrates in lignocellulosic hydrolysates by microorganisms, from the perspectives of sugar transport, sugar assimilation, and carbon catabolite inhibition. |
| first_indexed | 2024-04-12T10:33:00Z |
| format | Article |
| id | doaj.art-b74cff7ef63241d4a943f0db64b6f36b |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-04-12T10:33:00Z |
| publishDate | 2022-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-b74cff7ef63241d4a943f0db64b6f36b2022-12-22T03:36:48ZengElsevieriScience2589-00422022-11-012511105462Microbial cell factories for bio-based biodegradable plastics productionXiao Han0Jiongqin Liu1Sen Tian2Fei Tao3Ping Xu4State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic and Developmental Sciences and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, ChinaState Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic and Developmental Sciences and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, ChinaState Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic and Developmental Sciences and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, ChinaState Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic and Developmental Sciences and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China; Corresponding authorState Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic and Developmental Sciences and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China; Corresponding authorSummary: The misuse of petroleum-based plastics has resulted in serious environmental pollution and resource wastage. Biodegradable plastics can be used as green substitutes for traditional plastics. Here, we discuss the feasibility and technical bottlenecks in developing microbial cell factories for the production of biodegradable plastics from lignocellulosic wastes. First, we introduce the basic properties of the main biodegradable plastics on the market, including poly(lactic acid), poly(hydroxyalkanoate), and poly(butylene adipate-co-terephthalate). We then demonstrate the feasibility of synthesizing petroleum-based biodegradable plastic monomers from bio-based raw materials and propose strategies to further advance their commercial production through metabolic engineering and synthetic biology. We also analyze the main challenges facing the current development of bio-based biodegradable plastic biosynthesis technology. Finally, we discuss the current major lignocellulose bioconversion processes and explore way to further improve the utilization efficiency of the main carbohydrates in lignocellulosic hydrolysates by microorganisms, from the perspectives of sugar transport, sugar assimilation, and carbon catabolite inhibition.http://www.sciencedirect.com/science/article/pii/S2589004222017345MicrobiologyApplied microbiologyBiotechnologyBiomass |
| spellingShingle | Xiao Han Jiongqin Liu Sen Tian Fei Tao Ping Xu Microbial cell factories for bio-based biodegradable plastics production iScience Microbiology Applied microbiology Biotechnology Biomass |
| title | Microbial cell factories for bio-based biodegradable plastics production |
| title_full | Microbial cell factories for bio-based biodegradable plastics production |
| title_fullStr | Microbial cell factories for bio-based biodegradable plastics production |
| title_full_unstemmed | Microbial cell factories for bio-based biodegradable plastics production |
| title_short | Microbial cell factories for bio-based biodegradable plastics production |
| title_sort | microbial cell factories for bio based biodegradable plastics production |
| topic | Microbiology Applied microbiology Biotechnology Biomass |
| url | http://www.sciencedirect.com/science/article/pii/S2589004222017345 |
| work_keys_str_mv | AT xiaohan microbialcellfactoriesforbiobasedbiodegradableplasticsproduction AT jiongqinliu microbialcellfactoriesforbiobasedbiodegradableplasticsproduction AT sentian microbialcellfactoriesforbiobasedbiodegradableplasticsproduction AT feitao microbialcellfactoriesforbiobasedbiodegradableplasticsproduction AT pingxu microbialcellfactoriesforbiobasedbiodegradableplasticsproduction |