Structural insights into the mechanism of pancreatic KATP channel regulation by nucleotides
KATP channels are energy sensors. Here, authors report the Cryo-EM structures of pancreatic KATP in both the closed state and the pre-open state. These structures illuminate the mechanism of KATP channel regulation by the intracellular nucleotides.
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-05-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-30430-4 |
| _version_ | 1818548119333240832 |
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| author | Mengmeng Wang Jing-Xiang Wu Dian Ding Lei Chen |
| author_facet | Mengmeng Wang Jing-Xiang Wu Dian Ding Lei Chen |
| author_sort | Mengmeng Wang |
| collection | DOAJ |
| description | KATP channels are energy sensors. Here, authors report the Cryo-EM structures of pancreatic KATP in both the closed state and the pre-open state. These structures illuminate the mechanism of KATP channel regulation by the intracellular nucleotides. |
| first_indexed | 2024-12-12T08:15:41Z |
| format | Article |
| id | doaj.art-b74e9dfbf03d4845bf182890861ed3a8 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-12T08:15:41Z |
| publishDate | 2022-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-b74e9dfbf03d4845bf182890861ed3a82022-12-22T00:31:37ZengNature PortfolioNature Communications2041-17232022-05-0113111010.1038/s41467-022-30430-4Structural insights into the mechanism of pancreatic KATP channel regulation by nucleotidesMengmeng Wang0Jing-Xiang Wu1Dian Ding2Lei Chen3State Key Laboratory of Membrane Biology, College of Future Technology, Institute of Molecular Medicine, Peking University, Beijing Key Laboratory of Cardiometabolic Molecular MedicineState Key Laboratory of Membrane Biology, College of Future Technology, Institute of Molecular Medicine, Peking University, Beijing Key Laboratory of Cardiometabolic Molecular MedicineState Key Laboratory of Membrane Biology, College of Future Technology, Institute of Molecular Medicine, Peking University, Beijing Key Laboratory of Cardiometabolic Molecular MedicineState Key Laboratory of Membrane Biology, College of Future Technology, Institute of Molecular Medicine, Peking University, Beijing Key Laboratory of Cardiometabolic Molecular MedicineKATP channels are energy sensors. Here, authors report the Cryo-EM structures of pancreatic KATP in both the closed state and the pre-open state. These structures illuminate the mechanism of KATP channel regulation by the intracellular nucleotides.https://doi.org/10.1038/s41467-022-30430-4 |
| spellingShingle | Mengmeng Wang Jing-Xiang Wu Dian Ding Lei Chen Structural insights into the mechanism of pancreatic KATP channel regulation by nucleotides Nature Communications |
| title | Structural insights into the mechanism of pancreatic KATP channel regulation by nucleotides |
| title_full | Structural insights into the mechanism of pancreatic KATP channel regulation by nucleotides |
| title_fullStr | Structural insights into the mechanism of pancreatic KATP channel regulation by nucleotides |
| title_full_unstemmed | Structural insights into the mechanism of pancreatic KATP channel regulation by nucleotides |
| title_short | Structural insights into the mechanism of pancreatic KATP channel regulation by nucleotides |
| title_sort | structural insights into the mechanism of pancreatic katp channel regulation by nucleotides |
| url | https://doi.org/10.1038/s41467-022-30430-4 |
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