Clinical presentation of Warburg effect in aggressive lymphoma: a case report
Abstract Background The Warburg effect is a rare condition in tumor biology, illustrated by significant lactate production in the presence of oxygen. The Warburg effect is associated with very poor prognosis in patients with malignancy. Case presentation We report a 76-year-old Caucasian woman with...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-08-01
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| Series: | Journal of Medical Case Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13256-023-04079-6 |
| _version_ | 1797559492369448960 |
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| author | Yenong Cao Margaret C. Liu Emma L. Hanlon York Chen Muhammad Z. Afzal Christi A. Hayes John M. Hill |
| author_facet | Yenong Cao Margaret C. Liu Emma L. Hanlon York Chen Muhammad Z. Afzal Christi A. Hayes John M. Hill |
| author_sort | Yenong Cao |
| collection | DOAJ |
| description | Abstract Background The Warburg effect is a rare condition in tumor biology, illustrated by significant lactate production in the presence of oxygen. The Warburg effect is associated with very poor prognosis in patients with malignancy. Case presentation We report a 76-year-old Caucasian woman with double-expressor diffuse large B cell lymphoma who presented with severe lactic acidosis and extreme hypoglycemia with normal mentation. Her lactic acidosis was initially controlled with a bicarbonate infusion, and the patient was started promptly on steroids, followed by chemotherapy, but her clinical course was complicated by tumor lysis syndrome, acute renal failure requiring hemodialysis, and progressive liver failure. She manifested a temporary clinical response to chemotherapy but eventually died of complications. Conclusions This case demonstrates the importance of prompt recognition of the Warburg effect, aggressive supportive measures, and early initiation of chemotherapy. Future studies are needed to characterize the role of hemodialysis in this setting. |
| first_indexed | 2024-03-10T17:46:10Z |
| format | Article |
| id | doaj.art-b74f420a53c54a4e80be09ed18c50766 |
| institution | Directory Open Access Journal |
| issn | 1752-1947 |
| language | English |
| last_indexed | 2024-03-10T17:46:10Z |
| publishDate | 2023-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Medical Case Reports |
| spelling | doaj.art-b74f420a53c54a4e80be09ed18c507662023-11-20T09:31:45ZengBMCJournal of Medical Case Reports1752-19472023-08-011711510.1186/s13256-023-04079-6Clinical presentation of Warburg effect in aggressive lymphoma: a case reportYenong Cao0Margaret C. Liu1Emma L. Hanlon2York Chen3Muhammad Z. Afzal4Christi A. Hayes5John M. Hill6Department of Hematology and Oncology, Tufts Medical Center Division of Gastroenterology and Hepatology, Mayo ClinicBeth Israel Deaconess Medical CenterDepartment of Internal Medicine, Dartmouth HealthDivision of Hematology and Oncology, Dartmouth Cancer CenterDivision of Hematology and Oncology, Dartmouth Cancer CenterDivision of Hematology and Oncology, Dartmouth Cancer CenterAbstract Background The Warburg effect is a rare condition in tumor biology, illustrated by significant lactate production in the presence of oxygen. The Warburg effect is associated with very poor prognosis in patients with malignancy. Case presentation We report a 76-year-old Caucasian woman with double-expressor diffuse large B cell lymphoma who presented with severe lactic acidosis and extreme hypoglycemia with normal mentation. Her lactic acidosis was initially controlled with a bicarbonate infusion, and the patient was started promptly on steroids, followed by chemotherapy, but her clinical course was complicated by tumor lysis syndrome, acute renal failure requiring hemodialysis, and progressive liver failure. She manifested a temporary clinical response to chemotherapy but eventually died of complications. Conclusions This case demonstrates the importance of prompt recognition of the Warburg effect, aggressive supportive measures, and early initiation of chemotherapy. Future studies are needed to characterize the role of hemodialysis in this setting.https://doi.org/10.1186/s13256-023-04079-6Warburg effectDiffuse large B cell lymphomaAcute renal failureCase report |
| spellingShingle | Yenong Cao Margaret C. Liu Emma L. Hanlon York Chen Muhammad Z. Afzal Christi A. Hayes John M. Hill Clinical presentation of Warburg effect in aggressive lymphoma: a case report Journal of Medical Case Reports Warburg effect Diffuse large B cell lymphoma Acute renal failure Case report |
| title | Clinical presentation of Warburg effect in aggressive lymphoma: a case report |
| title_full | Clinical presentation of Warburg effect in aggressive lymphoma: a case report |
| title_fullStr | Clinical presentation of Warburg effect in aggressive lymphoma: a case report |
| title_full_unstemmed | Clinical presentation of Warburg effect in aggressive lymphoma: a case report |
| title_short | Clinical presentation of Warburg effect in aggressive lymphoma: a case report |
| title_sort | clinical presentation of warburg effect in aggressive lymphoma a case report |
| topic | Warburg effect Diffuse large B cell lymphoma Acute renal failure Case report |
| url | https://doi.org/10.1186/s13256-023-04079-6 |
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