Visual Deprivation Retards the Maturation of Dendritic Fields and Receptive Fields of Mouse Retinal Ganglion Cells
It was well documented that both the size of the dendritic field and receptive field of retinal ganglion cells (RGCs) are developmentally regulated in the mammalian retina, and visual stimulation is required for the maturation of the dendritic and receptive fields of mouse RGCs. However, it is not c...
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| Format: | Article |
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Frontiers Media S.A.
2021-04-01
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| Series: | Frontiers in Cellular Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fncel.2021.640421/full |
| _version_ | 1818640015264055296 |
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| author | Hui Chen Hong-Ping Xu Ping Wang Ning Tian Ning Tian |
| author_facet | Hui Chen Hong-Ping Xu Ping Wang Ning Tian Ning Tian |
| author_sort | Hui Chen |
| collection | DOAJ |
| description | It was well documented that both the size of the dendritic field and receptive field of retinal ganglion cells (RGCs) are developmentally regulated in the mammalian retina, and visual stimulation is required for the maturation of the dendritic and receptive fields of mouse RGCs. However, it is not clear whether the developmental changes of the RGC receptive field correlate with the dendritic field and whether visual stimulation regulates the maturation of the dendritic field and receptive field of RGCs in a correlated manner. The present work demonstrated that both the dendritic and receptive fields of RGCs continuously develop after eye opening. However, the correlation between the developmental changes in the receptive field size and the dendritic field varies among different RGC types. These results suggest a continuous change of synaptic converging of RGC synaptic inputs in an RGC type-dependent manner. Besides, light deprivation impairs both the development of dendritic and receptive fields. |
| first_indexed | 2024-12-16T23:04:33Z |
| format | Article |
| id | doaj.art-b74fb7026660484aaec4fa3adc15aefb |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-12-16T23:04:33Z |
| publishDate | 2021-04-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-b74fb7026660484aaec4fa3adc15aefb2022-12-21T22:12:36ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022021-04-011510.3389/fncel.2021.640421640421Visual Deprivation Retards the Maturation of Dendritic Fields and Receptive Fields of Mouse Retinal Ganglion CellsHui Chen0Hong-Ping Xu1Ping Wang2Ning Tian3Ning Tian4Department of Ophthalmology and Visual Science, University of Utah School of Medicine, Salt Lake City, UT, United StatesDepartment of Neurobiology, Yale University School of Medicine, New Haven, CT, United StatesDepartment of Ophthalmology and Visual Science, University of Utah School of Medicine, Salt Lake City, UT, United StatesDepartment of Ophthalmology and Visual Science, University of Utah School of Medicine, Salt Lake City, UT, United StatesVA Salt Lake City Health Care System, Salt Lake City, UT, United StatesIt was well documented that both the size of the dendritic field and receptive field of retinal ganglion cells (RGCs) are developmentally regulated in the mammalian retina, and visual stimulation is required for the maturation of the dendritic and receptive fields of mouse RGCs. However, it is not clear whether the developmental changes of the RGC receptive field correlate with the dendritic field and whether visual stimulation regulates the maturation of the dendritic field and receptive field of RGCs in a correlated manner. The present work demonstrated that both the dendritic and receptive fields of RGCs continuously develop after eye opening. However, the correlation between the developmental changes in the receptive field size and the dendritic field varies among different RGC types. These results suggest a continuous change of synaptic converging of RGC synaptic inputs in an RGC type-dependent manner. Besides, light deprivation impairs both the development of dendritic and receptive fields.https://www.frontiersin.org/articles/10.3389/fncel.2021.640421/fulldendritic morphologydevelopmentretinal ganglion cellactivity-dependent plasticitylight deprivationreceptive field (RF) |
| spellingShingle | Hui Chen Hong-Ping Xu Ping Wang Ning Tian Ning Tian Visual Deprivation Retards the Maturation of Dendritic Fields and Receptive Fields of Mouse Retinal Ganglion Cells Frontiers in Cellular Neuroscience dendritic morphology development retinal ganglion cell activity-dependent plasticity light deprivation receptive field (RF) |
| title | Visual Deprivation Retards the Maturation of Dendritic Fields and Receptive Fields of Mouse Retinal Ganglion Cells |
| title_full | Visual Deprivation Retards the Maturation of Dendritic Fields and Receptive Fields of Mouse Retinal Ganglion Cells |
| title_fullStr | Visual Deprivation Retards the Maturation of Dendritic Fields and Receptive Fields of Mouse Retinal Ganglion Cells |
| title_full_unstemmed | Visual Deprivation Retards the Maturation of Dendritic Fields and Receptive Fields of Mouse Retinal Ganglion Cells |
| title_short | Visual Deprivation Retards the Maturation of Dendritic Fields and Receptive Fields of Mouse Retinal Ganglion Cells |
| title_sort | visual deprivation retards the maturation of dendritic fields and receptive fields of mouse retinal ganglion cells |
| topic | dendritic morphology development retinal ganglion cell activity-dependent plasticity light deprivation receptive field (RF) |
| url | https://www.frontiersin.org/articles/10.3389/fncel.2021.640421/full |
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