Characteristics of 18F⁃FDG PET in Creutzfeldt⁃Jakob disease
Objective To explore the characteristics of 18F⁃fluoro⁃2⁃deoxy⁃D⁃glucose (18F⁃FDG) PET in Creutzfeldt⁃Jakob disease (CJD). Methods and Results The manifestations of 18F⁃FDG PET of 8 cases confirmed as CJD were analyzed retrospectively from August 2018 to January 2020. Five patients were male and 3 w...
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| Format: | Article |
| Language: | English |
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Tianjin Huanhu Hospital
2021-05-01
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| Series: | Chinese Journal of Contemporary Neurology and Neurosurgery |
| Subjects: | |
| Online Access: | http://www.cjcnn.org/index.php/cjcnn/article/view/2326 |
| _version_ | 1818735199285936128 |
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| author | LIN Xue ZHEN Zhen YI Fang YANG Ji⁃gang GUAN Hong⁃zhi SHI Qi LIU Lei WANG Jia⁃wei GUO Yan⁃jun |
| author_facet | LIN Xue ZHEN Zhen YI Fang YANG Ji⁃gang GUAN Hong⁃zhi SHI Qi LIU Lei WANG Jia⁃wei GUO Yan⁃jun |
| author_sort | LIN Xue |
| collection | DOAJ |
| description | Objective To explore the characteristics of 18F⁃fluoro⁃2⁃deoxy⁃D⁃glucose (18F⁃FDG) PET in Creutzfeldt⁃Jakob disease (CJD). Methods and Results The manifestations of 18F⁃FDG PET of 8 cases confirmed as CJD were analyzed retrospectively from August 2018 to January 2020. Five patients were male and 3 were female, with a mean age of (49.63±13.19) years. There were 7 sporadic CJD (sCJD) patients and one genetic CJD (gCJD) patient. All 8 patients were characterized by rapid progressive dementia. DWI hyperintensity in brain MRI were observed in all 8 patients. 18F⁃FDG PET analysis revealed frontal, parietal and temporal regions hypometabolism in all 8 cases. Occipital region hypometabolism was observed in 7 cases (7/8). For subcortical regions, hypometabolism were identified in thalamus (5/8), basal ganglia (3/8), brainstem (3/8) and cerebellum (3/8). Compared with the DWI hyperintensities, there were 40 hyperintense on DWI in the 50 cortical regions that were hypometabolic on 18F⁃FDG PET, especially in the frontal lobe. For subcortical regions, there were only 9 hyperintense on DWI in the 25 regions that were hypometabolic on 18F⁃FDG PET, especially the basal ganglia region. The brain stem and cerebellum hypometabolic regions showed no hyperintense on DWI. Conclusions The higher sensitivity of 18F⁃FDG PET is conducive to the differential diagnosis of CJD, especially in patients with rapid progression. 18F⁃FDG PET hypometabolism may indicate severe focal neurological impairment. The diagnosis of CJD should be considered for patients with rapidly progressive dementia accompanied with obvious symptoms of extra pyramidal system or cerebellum, cortical hypometabolism in 18F⁃FDG PET, and without obvious DWI hyperintensity. |
| first_indexed | 2024-12-18T00:17:27Z |
| format | Article |
| id | doaj.art-b7533f7b192545f29be4caa8e37d5617 |
| institution | Directory Open Access Journal |
| issn | 1672-6731 1672-6731 |
| language | English |
| last_indexed | 2024-12-18T00:17:27Z |
| publishDate | 2021-05-01 |
| publisher | Tianjin Huanhu Hospital |
| record_format | Article |
| series | Chinese Journal of Contemporary Neurology and Neurosurgery |
| spelling | doaj.art-b7533f7b192545f29be4caa8e37d56172022-12-21T21:27:28ZengTianjin Huanhu HospitalChinese Journal of Contemporary Neurology and Neurosurgery1672-67311672-67312021-05-01210537137710.3969/j.issn.1672⁃6731.2021.05.007Characteristics of 18F⁃FDG PET in Creutzfeldt⁃Jakob diseaseLIN Xue 0 ZHEN Zhen1 YI Fang2 YANG Ji⁃gang3GUAN Hong⁃zhi 4 SHI Qi5 LIU Lei 6 WANG Jia⁃wei7GUO Yan⁃jun 8Department of Neurology,Beijing Tongren Hospital, Capital Medical University, Beijing 100730, ChinaDepartment of Neurology,Beijing Tongren Hospital, Capital Medical University, Beijing 100730, ChinaDepartment of Neurology, PLA Rocket Force General Hospital, Beijing 100088, ChinaDepartment of Nuclear Medicine, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, ChinaDepartment of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, ChinaNational Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China Department of Neurology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, ChinaDepartment of Neurology,Medical Research Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China Department of Neurology,Beijing Tongren Hospital, Capital Medical University, Beijing 100730, ChinaObjective To explore the characteristics of 18F⁃fluoro⁃2⁃deoxy⁃D⁃glucose (18F⁃FDG) PET in Creutzfeldt⁃Jakob disease (CJD). Methods and Results The manifestations of 18F⁃FDG PET of 8 cases confirmed as CJD were analyzed retrospectively from August 2018 to January 2020. Five patients were male and 3 were female, with a mean age of (49.63±13.19) years. There were 7 sporadic CJD (sCJD) patients and one genetic CJD (gCJD) patient. All 8 patients were characterized by rapid progressive dementia. DWI hyperintensity in brain MRI were observed in all 8 patients. 18F⁃FDG PET analysis revealed frontal, parietal and temporal regions hypometabolism in all 8 cases. Occipital region hypometabolism was observed in 7 cases (7/8). For subcortical regions, hypometabolism were identified in thalamus (5/8), basal ganglia (3/8), brainstem (3/8) and cerebellum (3/8). Compared with the DWI hyperintensities, there were 40 hyperintense on DWI in the 50 cortical regions that were hypometabolic on 18F⁃FDG PET, especially in the frontal lobe. For subcortical regions, there were only 9 hyperintense on DWI in the 25 regions that were hypometabolic on 18F⁃FDG PET, especially the basal ganglia region. The brain stem and cerebellum hypometabolic regions showed no hyperintense on DWI. Conclusions The higher sensitivity of 18F⁃FDG PET is conducive to the differential diagnosis of CJD, especially in patients with rapid progression. 18F⁃FDG PET hypometabolism may indicate severe focal neurological impairment. The diagnosis of CJD should be considered for patients with rapidly progressive dementia accompanied with obvious symptoms of extra pyramidal system or cerebellum, cortical hypometabolism in 18F⁃FDG PET, and without obvious DWI hyperintensity.http://www.cjcnn.org/index.php/cjcnn/article/view/2326creutzfeldt ⁃ jakob syndromemagnetic resonance imagingpositron ⁃ emission tomographyfluorodeoxyglucose f18 |
| spellingShingle | LIN Xue ZHEN Zhen YI Fang YANG Ji⁃gang GUAN Hong⁃zhi SHI Qi LIU Lei WANG Jia⁃wei GUO Yan⁃jun Characteristics of 18F⁃FDG PET in Creutzfeldt⁃Jakob disease Chinese Journal of Contemporary Neurology and Neurosurgery creutzfeldt ⁃ jakob syndrome magnetic resonance imaging positron ⁃ emission tomography fluorodeoxyglucose f18 |
| title | Characteristics of 18F⁃FDG PET in Creutzfeldt⁃Jakob disease |
| title_full | Characteristics of 18F⁃FDG PET in Creutzfeldt⁃Jakob disease |
| title_fullStr | Characteristics of 18F⁃FDG PET in Creutzfeldt⁃Jakob disease |
| title_full_unstemmed | Characteristics of 18F⁃FDG PET in Creutzfeldt⁃Jakob disease |
| title_short | Characteristics of 18F⁃FDG PET in Creutzfeldt⁃Jakob disease |
| title_sort | characteristics of 18f⁃fdg pet in creutzfeldt⁃jakob disease |
| topic | creutzfeldt ⁃ jakob syndrome magnetic resonance imaging positron ⁃ emission tomography fluorodeoxyglucose f18 |
| url | http://www.cjcnn.org/index.php/cjcnn/article/view/2326 |
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