Vanadium Dioxide Circuits Emulate Neurological Disorders
Information in the central nervous system (CNS) is conducted via electrical signals known as action potentials and is encoded in time. Several neurological disorders including depression, Attention Deficit Hyperactivity Disorder (ADHD), originate in faulty brain signaling frequencies. Here, we prese...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2018-11-01
|
| Series: | Frontiers in Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fnins.2018.00856/full |
| _version_ | 1828179567844524032 |
|---|---|
| author | Jianqiang Lin Jianqiang Lin Supratik Guha Supratik Guha Shriram Ramanathan Shriram Ramanathan |
| author_facet | Jianqiang Lin Jianqiang Lin Supratik Guha Supratik Guha Shriram Ramanathan Shriram Ramanathan |
| author_sort | Jianqiang Lin |
| collection | DOAJ |
| description | Information in the central nervous system (CNS) is conducted via electrical signals known as action potentials and is encoded in time. Several neurological disorders including depression, Attention Deficit Hyperactivity Disorder (ADHD), originate in faulty brain signaling frequencies. Here, we present a Hodgkin-Huxley model analog for a strongly correlated VO2 artificial neuron system that undergoes an electrically-driven insulator-metal transition. We demonstrate that tuning of the insulating phase resistance in VO2 threshold switch circuits can enable direct mimicry of neuronal origins of disorders in the CNS. The results introduce use of circuits based on quantum materials as complementary to model animal studies for neuroscience, especially when precise measurements of local electrical properties or competing parallel paths for conduction in complex neural circuits can be a challenge to identify onset of breakdown or diagnose early symptoms of disease. |
| first_indexed | 2024-04-12T05:31:33Z |
| format | Article |
| id | doaj.art-b75463da25514c37b6f91ed6b4d6a2dd |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-04-12T05:31:33Z |
| publishDate | 2018-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-b75463da25514c37b6f91ed6b4d6a2dd2022-12-22T03:46:02ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2018-11-011210.3389/fnins.2018.00856402926Vanadium Dioxide Circuits Emulate Neurological DisordersJianqiang Lin0Jianqiang Lin1Supratik Guha2Supratik Guha3Shriram Ramanathan4Shriram Ramanathan5Center for Nanoscale Materials, Argonne National Laboratory, Lemont, IL, United StatesInstitute for Molecular Engineering, University of Chicago, Chicago, IL, United StatesCenter for Nanoscale Materials, Argonne National Laboratory, Lemont, IL, United StatesInstitute for Molecular Engineering, University of Chicago, Chicago, IL, United StatesSchool of Materials Engineering, Purdue University, West Lafayette, IN, United StatesSchool of Electrical and Computer Engineering, Purdue University, West Lafayette, IN, United StatesInformation in the central nervous system (CNS) is conducted via electrical signals known as action potentials and is encoded in time. Several neurological disorders including depression, Attention Deficit Hyperactivity Disorder (ADHD), originate in faulty brain signaling frequencies. Here, we present a Hodgkin-Huxley model analog for a strongly correlated VO2 artificial neuron system that undergoes an electrically-driven insulator-metal transition. We demonstrate that tuning of the insulating phase resistance in VO2 threshold switch circuits can enable direct mimicry of neuronal origins of disorders in the CNS. The results introduce use of circuits based on quantum materials as complementary to model animal studies for neuroscience, especially when precise measurements of local electrical properties or competing parallel paths for conduction in complex neural circuits can be a challenge to identify onset of breakdown or diagnose early symptoms of disease.https://www.frontiersin.org/article/10.3389/fnins.2018.00856/fullstrongly correlated systemsVO2central nervous system diseasesHodgkin-Huxley modelartificial neurons |
| spellingShingle | Jianqiang Lin Jianqiang Lin Supratik Guha Supratik Guha Shriram Ramanathan Shriram Ramanathan Vanadium Dioxide Circuits Emulate Neurological Disorders Frontiers in Neuroscience strongly correlated systems VO2 central nervous system diseases Hodgkin-Huxley model artificial neurons |
| title | Vanadium Dioxide Circuits Emulate Neurological Disorders |
| title_full | Vanadium Dioxide Circuits Emulate Neurological Disorders |
| title_fullStr | Vanadium Dioxide Circuits Emulate Neurological Disorders |
| title_full_unstemmed | Vanadium Dioxide Circuits Emulate Neurological Disorders |
| title_short | Vanadium Dioxide Circuits Emulate Neurological Disorders |
| title_sort | vanadium dioxide circuits emulate neurological disorders |
| topic | strongly correlated systems VO2 central nervous system diseases Hodgkin-Huxley model artificial neurons |
| url | https://www.frontiersin.org/article/10.3389/fnins.2018.00856/full |
| work_keys_str_mv | AT jianqianglin vanadiumdioxidecircuitsemulateneurologicaldisorders AT jianqianglin vanadiumdioxidecircuitsemulateneurologicaldisorders AT supratikguha vanadiumdioxidecircuitsemulateneurologicaldisorders AT supratikguha vanadiumdioxidecircuitsemulateneurologicaldisorders AT shriramramanathan vanadiumdioxidecircuitsemulateneurologicaldisorders AT shriramramanathan vanadiumdioxidecircuitsemulateneurologicaldisorders |