Phillygenin Suppresses Glutamate Exocytosis in Rat Cerebrocortical Nerve Terminals (Synaptosomes) through the Inhibition of Ca<sub>v</sub>2.2 Calcium Channels

Glutamate is a major excitatory neurotransmitter that mediates neuronal damage in acute and chronic brain disorders. The effect and mechanism of phillygenin, a natural compound with neuroprotective potential, on glutamate release in isolated nerve terminals (synaptosomes) prepared from the rat cereb...

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Bibliographic Details
Main Authors: Ming-Yi Lee, Tzu-Yu Lin, Ya-Ying Chang, Kuan-Ming Chiu, Su-Jane Wang
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:Biomedicines
Subjects:
Online Access:https://www.mdpi.com/2227-9059/12/3/495