Possible connection between intestinal tuft cells, ILC2s and obesity
Intestinal tuft cells (TCs) are defined as chemosensory cells that can “taste” danger and induce immune responses. They play a critical role in gastrointestinal parasite invasion, inflammatory bowel diseases and high-fat diet-induced obesity. Intestinal IL-25, the unique product of TCs, is a key act...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1266667/full |
| _version_ | 1827383185571315712 |
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| author | Hong Yang Yu-Xing Huang Yu-Xing Huang Pei-Yu Xiong Jin-Qian Li Ji-Lan Chen Xia Liu Yan-Ju Gong Wei-Jun Ding |
| author_facet | Hong Yang Yu-Xing Huang Yu-Xing Huang Pei-Yu Xiong Jin-Qian Li Ji-Lan Chen Xia Liu Yan-Ju Gong Wei-Jun Ding |
| author_sort | Hong Yang |
| collection | DOAJ |
| description | Intestinal tuft cells (TCs) are defined as chemosensory cells that can “taste” danger and induce immune responses. They play a critical role in gastrointestinal parasite invasion, inflammatory bowel diseases and high-fat diet-induced obesity. Intestinal IL-25, the unique product of TCs, is a key activator of type 2 immunity, especially to promote group 2 innate lymphoid cells (ILC2s) to secret IL-13. Then the IL-13 mainly promotes intestinal stem cell (ISCs) proliferation into TCs and goblet cells. This pathway formulates the circuit in the intestine. This paper focuses on the potential role of the intestinal TC, ILC2 and their circuit in obesity-induced intestinal damage, and discussion on further study and the potential therapeutic target in obesity. |
| first_indexed | 2024-03-08T14:37:35Z |
| format | Article |
| id | doaj.art-b754e2a2ab1644a6a0300725e93aba7a |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-08T14:37:35Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-b754e2a2ab1644a6a0300725e93aba7a2024-01-12T04:19:00ZengFrontiers Media S.A.Frontiers in Immunology1664-32242024-01-011410.3389/fimmu.2023.12666671266667Possible connection between intestinal tuft cells, ILC2s and obesityHong Yang0Yu-Xing Huang1Yu-Xing Huang2Pei-Yu Xiong3Jin-Qian Li4Ji-Lan Chen5Xia Liu6Yan-Ju Gong7Wei-Jun Ding8Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaChengdu University of Traditional Chinese Medicine, Chengdu, ChinaHospital of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaChengdu University of Traditional Chinese Medicine, Chengdu, ChinaChengdu University of Traditional Chinese Medicine, Chengdu, ChinaChengdu University of Traditional Chinese Medicine, Chengdu, ChinaChengdu University of Traditional Chinese Medicine, Chengdu, ChinaChengdu University of Traditional Chinese Medicine, Chengdu, ChinaChengdu University of Traditional Chinese Medicine, Chengdu, ChinaIntestinal tuft cells (TCs) are defined as chemosensory cells that can “taste” danger and induce immune responses. They play a critical role in gastrointestinal parasite invasion, inflammatory bowel diseases and high-fat diet-induced obesity. Intestinal IL-25, the unique product of TCs, is a key activator of type 2 immunity, especially to promote group 2 innate lymphoid cells (ILC2s) to secret IL-13. Then the IL-13 mainly promotes intestinal stem cell (ISCs) proliferation into TCs and goblet cells. This pathway formulates the circuit in the intestine. This paper focuses on the potential role of the intestinal TC, ILC2 and their circuit in obesity-induced intestinal damage, and discussion on further study and the potential therapeutic target in obesity.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1266667/fullobesitytuft cell (TC)group 2 innate lymphoid cell (ILC2)TC-ILC2 circuitintestinal remodelingimmune homeostasis |
| spellingShingle | Hong Yang Yu-Xing Huang Yu-Xing Huang Pei-Yu Xiong Jin-Qian Li Ji-Lan Chen Xia Liu Yan-Ju Gong Wei-Jun Ding Possible connection between intestinal tuft cells, ILC2s and obesity Frontiers in Immunology obesity tuft cell (TC) group 2 innate lymphoid cell (ILC2) TC-ILC2 circuit intestinal remodeling immune homeostasis |
| title | Possible connection between intestinal tuft cells, ILC2s and obesity |
| title_full | Possible connection between intestinal tuft cells, ILC2s and obesity |
| title_fullStr | Possible connection between intestinal tuft cells, ILC2s and obesity |
| title_full_unstemmed | Possible connection between intestinal tuft cells, ILC2s and obesity |
| title_short | Possible connection between intestinal tuft cells, ILC2s and obesity |
| title_sort | possible connection between intestinal tuft cells ilc2s and obesity |
| topic | obesity tuft cell (TC) group 2 innate lymphoid cell (ILC2) TC-ILC2 circuit intestinal remodeling immune homeostasis |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1266667/full |
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