Exposure of Von Willebrand Factor Cleavage Site in A1A2A3-Fragment under Extreme Hydrodynamic Shear

Exposure of Von Willebrand Factor Cleavage Site in A1A2A3-Fragment under Extreme Hydrodynamic Shear

Von Willebrand Factor (vWf) is a giant multimeric extracellular blood plasma involved in hemostasis. In this work we present multi-scale simulations of its three-domains fragment A1A2A3. These three domains are essential for the functional regulation of vWf. Namely the A2 domain hosts the site where...

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Bibliographic Details
Main Authors: Olivier Languin-Cattoën, Emeline Laborie, Daria O. Yurkova, Simone Melchionna, Philippe Derreumaux, Aleksey V. Belyaev, Fabio Sterpone
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Polymers
Subjects:
von Willebrand factor
molecular dynamics
coarse-grains
lattice Boltzmann
shear flow
protein unfolding
Online Access:https://www.mdpi.com/2073-4360/13/22/3912

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