Hepatotoxicity of New Oral Anticoagulants
Aim. To summarize and systematize the information published in open sources on the development of various manifestations of liver damage in the use of the new oral anticoagulants (NOAC) for the registered indications and to analyze the published clinical cases of drug induced liver injury (DILI) dev...
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| Format: | Article |
| Language: | English |
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Столичная издательская компания
2018-09-01
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| Series: | Рациональная фармакотерапия в кардиологии |
| Subjects: | |
| Online Access: | https://www.rpcardio.online/jour/article/view/1734 |
| _version_ | 1826949664590528512 |
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| author | A. R. Kasimova A. V. Philippova (Guryanova) A. S. Kolbin |
| author_facet | A. R. Kasimova A. V. Philippova (Guryanova) A. S. Kolbin |
| author_sort | A. R. Kasimova |
| collection | DOAJ |
| description | Aim. To summarize and systematize the information published in open sources on the development of various manifestations of liver damage in the use of the new oral anticoagulants (NOAC) for the registered indications and to analyze the published clinical cases of drug induced liver injury (DILI) development.Material and methods. Search queries for keywords were made in the PubMed (MEDLINE), Scopus, Elibrary and Kiberleninka databases. The search query was composed of the name of the medicinal product (international non-proprietary and commercial name) or the common name of the group and words describing the different variants of the liver damage.Results. As a result of the search 1497 articles were found. Duplicate articles, articles that do not match the review topic, and articles whose full-text version is not available were removed from the search results. Articles that do not describe specific clinical cases have also been excluded. The review includes 14 articles, published from 2007 to March 2018 in Russian and English and one article in French describing clinical cases of different types of hepatotoxicity in the application of NOAC.Conclusions. Published clinical cases suggest that NOAC cause undesirable phenomena such as hepatotoxicity, the mechanism and frequency of which remain unclear. |
| first_indexed | 2024-03-08T14:02:25Z |
| format | Article |
| id | doaj.art-b75710bbc0b64968b76465a86e01fc73 |
| institution | Directory Open Access Journal |
| issn | 1819-6446 2225-3653 |
| language | English |
| last_indexed | 2025-02-17T22:18:05Z |
| publishDate | 2018-09-01 |
| publisher | Столичная издательская компания |
| record_format | Article |
| series | Рациональная фармакотерапия в кардиологии |
| spelling | doaj.art-b75710bbc0b64968b76465a86e01fc732024-12-04T11:48:15ZengСтоличная издательская компанияРациональная фармакотерапия в кардиологии1819-64462225-36532018-09-0114462162810.20996/1819-6446-2018-14-4-621-6281516Hepatotoxicity of New Oral AnticoagulantsA. R. Kasimova0A. V. Philippova (Guryanova)1A. S. Kolbin2Pavlov First Saint Petersburg State Medical University; Russian Scientific Research Institute of Traumatology and Orthopedics named after R.R. VredenPavlov First Saint Petersburg State Medical UniversityPavlov First Saint Petersburg State Medical UniversityAim. To summarize and systematize the information published in open sources on the development of various manifestations of liver damage in the use of the new oral anticoagulants (NOAC) for the registered indications and to analyze the published clinical cases of drug induced liver injury (DILI) development.Material and methods. Search queries for keywords were made in the PubMed (MEDLINE), Scopus, Elibrary and Kiberleninka databases. The search query was composed of the name of the medicinal product (international non-proprietary and commercial name) or the common name of the group and words describing the different variants of the liver damage.Results. As a result of the search 1497 articles were found. Duplicate articles, articles that do not match the review topic, and articles whose full-text version is not available were removed from the search results. Articles that do not describe specific clinical cases have also been excluded. The review includes 14 articles, published from 2007 to March 2018 in Russian and English and one article in French describing clinical cases of different types of hepatotoxicity in the application of NOAC.Conclusions. Published clinical cases suggest that NOAC cause undesirable phenomena such as hepatotoxicity, the mechanism and frequency of which remain unclear.https://www.rpcardio.online/jour/article/view/1734hepatotoxicitydrug-induced liver injurydabigatranrivaroxabanapixabannew oral anticoagulants |
| spellingShingle | A. R. Kasimova A. V. Philippova (Guryanova) A. S. Kolbin Hepatotoxicity of New Oral Anticoagulants Рациональная фармакотерапия в кардиологии hepatotoxicity drug-induced liver injury dabigatran rivaroxaban apixaban new oral anticoagulants |
| title | Hepatotoxicity of New Oral Anticoagulants |
| title_full | Hepatotoxicity of New Oral Anticoagulants |
| title_fullStr | Hepatotoxicity of New Oral Anticoagulants |
| title_full_unstemmed | Hepatotoxicity of New Oral Anticoagulants |
| title_short | Hepatotoxicity of New Oral Anticoagulants |
| title_sort | hepatotoxicity of new oral anticoagulants |
| topic | hepatotoxicity drug-induced liver injury dabigatran rivaroxaban apixaban new oral anticoagulants |
| url | https://www.rpcardio.online/jour/article/view/1734 |
| work_keys_str_mv | AT arkasimova hepatotoxicityofneworalanticoagulants AT avphilippovaguryanova hepatotoxicityofneworalanticoagulants AT askolbin hepatotoxicityofneworalanticoagulants |