The Effect of Post-Cardiopulmonary Resuscitation N-acetylcysteine on Renal Function: A Randomized Clinical Trial
Background: The purpose of our study was to determine the effect of N-acetylcysteine (NAC) administered after successful cardiopulmonary resuscitation (CPR) on renal function of the survived patients. Methods: In this double-blinded randomized clinical trial, 44 patients who experienced cardiopulmon...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2016-04-01
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| Series: | Archives of Anesthesia and Critical Care |
| Subjects: | |
| Online Access: | https://aacc.tums.ac.ir/index.php/aacc/article/view/62 |
| _version_ | 1818532183884693504 |
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| author | Gita Shoeibi Atabak Najafi Mostafa Sadeghi Shaqayeq Marashi Golnaz Moghimi Mehdi Sanatkar Amir Abbas Yaghooti |
| author_facet | Gita Shoeibi Atabak Najafi Mostafa Sadeghi Shaqayeq Marashi Golnaz Moghimi Mehdi Sanatkar Amir Abbas Yaghooti |
| author_sort | Gita Shoeibi |
| collection | DOAJ |
| description | Background: The purpose of our study was to determine the effect of N-acetylcysteine (NAC) administered after successful cardiopulmonary resuscitation (CPR) on renal function of the survived patients.
Methods: In this double-blinded randomized clinical trial, 44 patients who experienced cardiopulmonary arrest and underwent successful cardiopulmonary resuscitation (CPR) were entered into the study. They were randomly divided into two groups. One group received NAC (150 mg/kg) and the control group received normal saline (NS).
Results: Serum levels of blood urea nitrogen (BUN), creatinine, and neutrophil gelatinase-associated lipocalin (NGAL) were significantly lower in the NAC group when compared to the NS group at 6, 12,24, 48, and 72 hours after resuscitation. However, alanine aminotransferase (ALT), cardiac troponin, creatine kinase MB fraction (CK-MB) and arterial blood gases did not differ between the two groups.
Conclusion: We observed significantly lower serum levels of BUN, creatinine, and NGAL in patients who received NAC after successful CPR following cardiopulmonary arrest. This can be used in clinical practice to decrease the chance of developing renal failure in such patient population. |
| first_indexed | 2024-12-11T17:42:11Z |
| format | Article |
| id | doaj.art-b7583444d34044b99cea2e5a1d34ccf8 |
| institution | Directory Open Access Journal |
| issn | 2423-5849 |
| language | English |
| last_indexed | 2024-12-11T17:42:11Z |
| publishDate | 2016-04-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Archives of Anesthesia and Critical Care |
| spelling | doaj.art-b7583444d34044b99cea2e5a1d34ccf82022-12-22T00:56:29ZengTehran University of Medical SciencesArchives of Anesthesia and Critical Care2423-58492016-04-0121The Effect of Post-Cardiopulmonary Resuscitation N-acetylcysteine on Renal Function: A Randomized Clinical TrialGita Shoeibi0Atabak Najafi1Mostafa Sadeghi2Shaqayeq Marashi3Golnaz Moghimi4Mehdi Sanatkar5Amir Abbas Yaghooti6Department of Anesthesiology and Critical Care, Tehran University of Medical Sciences, Shariati Hospital, Tehran, IranDepartment of Anesthesiology and Critical Care, Tehran University of Medical Sciences, Sina Hospital, Tehran, IranDepartment of Anesthesiology and Critical Care, Tehran University of Medical Sciences, Shariati Hospital, Tehran, IranDepartment of Anesthesiology and Critical Care, Tehran University of Medical Sciences, Shariati Hospital, Tehran, IranDepartment of Anesthesiology and Critical Care, Tehran University of Medical Sciences, Shariati Hospital, Tehran, IranDepartment of Anesthesiology and Critical Care, Tehran University of Medical Sciences, Farabi Eye Hospital, Tehran, IranDepartment of Anesthesiology and Critical Care, Tehran University of Medical Sciences, Bahrami Hospital, Tehran, IranBackground: The purpose of our study was to determine the effect of N-acetylcysteine (NAC) administered after successful cardiopulmonary resuscitation (CPR) on renal function of the survived patients. Methods: In this double-blinded randomized clinical trial, 44 patients who experienced cardiopulmonary arrest and underwent successful cardiopulmonary resuscitation (CPR) were entered into the study. They were randomly divided into two groups. One group received NAC (150 mg/kg) and the control group received normal saline (NS). Results: Serum levels of blood urea nitrogen (BUN), creatinine, and neutrophil gelatinase-associated lipocalin (NGAL) were significantly lower in the NAC group when compared to the NS group at 6, 12,24, 48, and 72 hours after resuscitation. However, alanine aminotransferase (ALT), cardiac troponin, creatine kinase MB fraction (CK-MB) and arterial blood gases did not differ between the two groups. Conclusion: We observed significantly lower serum levels of BUN, creatinine, and NGAL in patients who received NAC after successful CPR following cardiopulmonary arrest. This can be used in clinical practice to decrease the chance of developing renal failure in such patient population.https://aacc.tums.ac.ir/index.php/aacc/article/view/62N-acetylcysteinekidneycreatinineblood urea nitrogencardiopulmonary arrestcardiopulmonary resuscitation |
| spellingShingle | Gita Shoeibi Atabak Najafi Mostafa Sadeghi Shaqayeq Marashi Golnaz Moghimi Mehdi Sanatkar Amir Abbas Yaghooti The Effect of Post-Cardiopulmonary Resuscitation N-acetylcysteine on Renal Function: A Randomized Clinical Trial Archives of Anesthesia and Critical Care N-acetylcysteine kidney creatinine blood urea nitrogen cardiopulmonary arrest cardiopulmonary resuscitation |
| title | The Effect of Post-Cardiopulmonary Resuscitation N-acetylcysteine on Renal Function: A Randomized Clinical Trial |
| title_full | The Effect of Post-Cardiopulmonary Resuscitation N-acetylcysteine on Renal Function: A Randomized Clinical Trial |
| title_fullStr | The Effect of Post-Cardiopulmonary Resuscitation N-acetylcysteine on Renal Function: A Randomized Clinical Trial |
| title_full_unstemmed | The Effect of Post-Cardiopulmonary Resuscitation N-acetylcysteine on Renal Function: A Randomized Clinical Trial |
| title_short | The Effect of Post-Cardiopulmonary Resuscitation N-acetylcysteine on Renal Function: A Randomized Clinical Trial |
| title_sort | effect of post cardiopulmonary resuscitation n acetylcysteine on renal function a randomized clinical trial |
| topic | N-acetylcysteine kidney creatinine blood urea nitrogen cardiopulmonary arrest cardiopulmonary resuscitation |
| url | https://aacc.tums.ac.ir/index.php/aacc/article/view/62 |
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