Febrile seizure in children with COVID-19 during the Omicron wave
ObjectiveTo explore the clinical characteristics and prognosis of febrile seizure in children with COVID-19.MethodsThis study is a single-center retrospective cohort study. The cases included febrile seizures in children with COVID-19 admitted to the Renji Hospital from April 7th, 2022 to June 2nd,...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-10-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2023.1197156/full |
| _version_ | 1828715860748926976 |
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| author | Pu Xu Xuelian Chen Jianguo Zhou Wenhao Zhou Laishuan Wang |
| author_facet | Pu Xu Xuelian Chen Jianguo Zhou Wenhao Zhou Laishuan Wang |
| author_sort | Pu Xu |
| collection | DOAJ |
| description | ObjectiveTo explore the clinical characteristics and prognosis of febrile seizure in children with COVID-19.MethodsThis study is a single-center retrospective cohort study. The cases included febrile seizures in children with COVID-19 admitted to the Renji Hospital from April 7th, 2022 to June 2nd, 2022. We compared children with and without febrile seizures in their clinical characteristics such as sex, age, symptoms, seizure manifestation, COVID-19 severity, and SARS-CoV-2 nucleic acid test results. The children with febrile seizures were followed up by telephone and outpatient service about one month after the nucleic acid turned negative and discharged from the hospital.ResultsA total of 585 cases of children with COVID-19 were included in the analysis. There were 15 children (1.8%) with febrile seizures, age from six months to three years old, nine boys (60.0%) and six girls (40.0%). The manifestations of febrile seizures were all generalized tonic-clonic seizures. The median nucleic acid negative conversion time was 11 (IQR:10.75,13) days. Our first comparison involved comparing children without underlying diseases; there was no significant difference in sex, COVID-19 severity, and clinical manifestations, but there was an age difference (2 vs. 1.3, P = 0.047). There was no difference in SARS-CoV-2 nucleic acid negative time between the two groups (11d vs. 13d, P = 0.128). One child had new clinical manifestations during the follow-up, but his EEG and MRI were normal.ConclusionFebrile seizure may be children's primary neurological manifestation of COVID-19. It may occur in children with no history of epilepsy and is not associated with severe illness. The long-term neurological outcomes of these children should be followed up. |
| first_indexed | 2024-03-11T16:58:36Z |
| format | Article |
| id | doaj.art-b759102765b047478efd3cab9938a281 |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-03-11T16:58:36Z |
| publishDate | 2023-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-b759102765b047478efd3cab9938a2812023-10-20T13:04:50ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602023-10-011110.3389/fped.2023.11971561197156Febrile seizure in children with COVID-19 during the Omicron wavePu Xu0Xuelian Chen1Jianguo Zhou2Wenhao Zhou3Laishuan Wang4National Health Commission Key Laboratory of Neonatal Diseases, Department of Neonatology, Children’s Hospital of Fudan University, Shanghai, ChinaDepartment of Obstetrics and Gynecology, Renji Hospital of Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaNational Health Commission Key Laboratory of Neonatal Diseases, Department of Neonatology, Children’s Hospital of Fudan University, Shanghai, ChinaNational Health Commission Key Laboratory of Neonatal Diseases, Department of Neonatology, Children’s Hospital of Fudan University, Shanghai, ChinaNational Health Commission Key Laboratory of Neonatal Diseases, Department of Neonatology, Children’s Hospital of Fudan University, Shanghai, ChinaObjectiveTo explore the clinical characteristics and prognosis of febrile seizure in children with COVID-19.MethodsThis study is a single-center retrospective cohort study. The cases included febrile seizures in children with COVID-19 admitted to the Renji Hospital from April 7th, 2022 to June 2nd, 2022. We compared children with and without febrile seizures in their clinical characteristics such as sex, age, symptoms, seizure manifestation, COVID-19 severity, and SARS-CoV-2 nucleic acid test results. The children with febrile seizures were followed up by telephone and outpatient service about one month after the nucleic acid turned negative and discharged from the hospital.ResultsA total of 585 cases of children with COVID-19 were included in the analysis. There were 15 children (1.8%) with febrile seizures, age from six months to three years old, nine boys (60.0%) and six girls (40.0%). The manifestations of febrile seizures were all generalized tonic-clonic seizures. The median nucleic acid negative conversion time was 11 (IQR:10.75,13) days. Our first comparison involved comparing children without underlying diseases; there was no significant difference in sex, COVID-19 severity, and clinical manifestations, but there was an age difference (2 vs. 1.3, P = 0.047). There was no difference in SARS-CoV-2 nucleic acid negative time between the two groups (11d vs. 13d, P = 0.128). One child had new clinical manifestations during the follow-up, but his EEG and MRI were normal.ConclusionFebrile seizure may be children's primary neurological manifestation of COVID-19. It may occur in children with no history of epilepsy and is not associated with severe illness. The long-term neurological outcomes of these children should be followed up.https://www.frontiersin.org/articles/10.3389/fped.2023.1197156/fullfebrile seizuresCOVID-19Omicronchildrenfebrile convulsions |
| spellingShingle | Pu Xu Xuelian Chen Jianguo Zhou Wenhao Zhou Laishuan Wang Febrile seizure in children with COVID-19 during the Omicron wave Frontiers in Pediatrics febrile seizures COVID-19 Omicron children febrile convulsions |
| title | Febrile seizure in children with COVID-19 during the Omicron wave |
| title_full | Febrile seizure in children with COVID-19 during the Omicron wave |
| title_fullStr | Febrile seizure in children with COVID-19 during the Omicron wave |
| title_full_unstemmed | Febrile seizure in children with COVID-19 during the Omicron wave |
| title_short | Febrile seizure in children with COVID-19 during the Omicron wave |
| title_sort | febrile seizure in children with covid 19 during the omicron wave |
| topic | febrile seizures COVID-19 Omicron children febrile convulsions |
| url | https://www.frontiersin.org/articles/10.3389/fped.2023.1197156/full |
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