Leptin in Teleost Fishes: An Argument for Comparative Study
All organisms face tradeoffs with regards to how limited energy resources should be invested. When is it most favorable to grow, to reproduce, how much lipid should be allocated to storage in preparation for a period of limited resources (e.g. winter), instead of being used for growth or maturation?...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2011-06-01
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| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fphys.2011.00026/full |
| _version_ | 1819055810324463616 |
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| author | Donald L Copeland Robert Joel Duff Qin eLiu Jeremy eProkop Richard Lyle Londraville |
| author_facet | Donald L Copeland Robert Joel Duff Qin eLiu Jeremy eProkop Richard Lyle Londraville |
| author_sort | Donald L Copeland |
| collection | DOAJ |
| description | All organisms face tradeoffs with regards to how limited energy resources should be invested. When is it most favorable to grow, to reproduce, how much lipid should be allocated to storage in preparation for a period of limited resources (e.g. winter), instead of being used for growth or maturation? These are a few of the high consequence fitness ‘decisions’ that represent the balance between energy acquisition and allocation. Indeed, for animals to make favorable decisions about when to grow, eat, or reproduce, they must integrate signals among the systems responsible for energy acquisition, storage, and demand. We make the argument that leptin signaling is a likely candidate for an integrating system. Great progress has been made understanding the leptin system in mammals, however our understanding in fishes has been hampered by difficulty in cloning fish orthologues of mammalian proteins and (we assert), underutilization of the comparative approach. |
| first_indexed | 2024-12-21T13:13:26Z |
| format | Article |
| id | doaj.art-b759f75932b44560a739cb76d08e2661 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-21T13:13:26Z |
| publishDate | 2011-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-b759f75932b44560a739cb76d08e26612022-12-21T19:02:48ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2011-06-01210.3389/fphys.2011.0002611023Leptin in Teleost Fishes: An Argument for Comparative StudyDonald L Copeland0Robert Joel Duff1Qin eLiu2Jeremy eProkop3Richard Lyle Londraville4University of AkronUniversity of AkronUniversity of AkronUniversity of AkronUniversity of AkronAll organisms face tradeoffs with regards to how limited energy resources should be invested. When is it most favorable to grow, to reproduce, how much lipid should be allocated to storage in preparation for a period of limited resources (e.g. winter), instead of being used for growth or maturation? These are a few of the high consequence fitness ‘decisions’ that represent the balance between energy acquisition and allocation. Indeed, for animals to make favorable decisions about when to grow, eat, or reproduce, they must integrate signals among the systems responsible for energy acquisition, storage, and demand. We make the argument that leptin signaling is a likely candidate for an integrating system. Great progress has been made understanding the leptin system in mammals, however our understanding in fishes has been hampered by difficulty in cloning fish orthologues of mammalian proteins and (we assert), underutilization of the comparative approach.http://journal.frontiersin.org/Journal/10.3389/fphys.2011.00026/fullLipid Metabolismendothermylife history strategy |
| spellingShingle | Donald L Copeland Robert Joel Duff Qin eLiu Jeremy eProkop Richard Lyle Londraville Leptin in Teleost Fishes: An Argument for Comparative Study Frontiers in Physiology Lipid Metabolism endothermy life history strategy |
| title | Leptin in Teleost Fishes: An Argument for Comparative Study |
| title_full | Leptin in Teleost Fishes: An Argument for Comparative Study |
| title_fullStr | Leptin in Teleost Fishes: An Argument for Comparative Study |
| title_full_unstemmed | Leptin in Teleost Fishes: An Argument for Comparative Study |
| title_short | Leptin in Teleost Fishes: An Argument for Comparative Study |
| title_sort | leptin in teleost fishes an argument for comparative study |
| topic | Lipid Metabolism endothermy life history strategy |
| url | http://journal.frontiersin.org/Journal/10.3389/fphys.2011.00026/full |
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