Pleiotrophin as a central nervous system neuromodulator, evidences from the hippocampus
Pleiotrophin (PTN) is a secreted growth factor, and also a cytokine, associated with the extracellular matrix, which has recently starting to attract attention as a significant neuromodulator with multiple neuronal functions during development. PTN is expressed in several tissues, where its signals...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-01-01
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| Series: | Frontiers in Cellular Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00443/full |
| _version_ | 1828328132893999104 |
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| author | Celia eGonzález-Castillo Daniel eOrtuño-Sahagún Carolina eGuzmán-Brambila Mercè ePalllàs Argelia Esperanza Rojas-Mayorquin |
| author_facet | Celia eGonzález-Castillo Daniel eOrtuño-Sahagún Carolina eGuzmán-Brambila Mercè ePalllàs Argelia Esperanza Rojas-Mayorquin |
| author_sort | Celia eGonzález-Castillo |
| collection | DOAJ |
| description | Pleiotrophin (PTN) is a secreted growth factor, and also a cytokine, associated with the extracellular matrix, which has recently starting to attract attention as a significant neuromodulator with multiple neuronal functions during development. PTN is expressed in several tissues, where its signals are generally related with cell proliferation, growth, and differentiation by acting through different receptors. In Central Nervous System (CNS), PTN exerts post-developmental neurotrophic and -protective effects, and additionally has been involved in neurodegenerative diseases and neural disorders. Studies in Drosophila shed light on some aspects of the different levels of regulatory control of PTN invertebrate homologs. Specifically in hippocampus, recent evidence from PTN Knock-out (KO) mice involves PTN functioning in learning and memory. In this paper, we summarize, discuss, and contrast the most recent advances and results that lead to proposing a PTN as a neuromodulatory molecule in the CNS, particularly in hippocampus. |
| first_indexed | 2024-04-13T20:05:20Z |
| format | Article |
| id | doaj.art-b75b8dd45ad44588897c724e9807fa81 |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-04-13T20:05:20Z |
| publishDate | 2015-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-b75b8dd45ad44588897c724e9807fa812022-12-22T02:32:02ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022015-01-01810.3389/fncel.2014.00443122169Pleiotrophin as a central nervous system neuromodulator, evidences from the hippocampusCelia eGonzález-Castillo0Daniel eOrtuño-Sahagún1Carolina eGuzmán-Brambila2Mercè ePalllàs3Argelia Esperanza Rojas-Mayorquin4University of GuadalajaraUniversity of GuadalajaraTecnológico de MonterreyUniversity of BarcelonaUniversity of GuadalajaraPleiotrophin (PTN) is a secreted growth factor, and also a cytokine, associated with the extracellular matrix, which has recently starting to attract attention as a significant neuromodulator with multiple neuronal functions during development. PTN is expressed in several tissues, where its signals are generally related with cell proliferation, growth, and differentiation by acting through different receptors. In Central Nervous System (CNS), PTN exerts post-developmental neurotrophic and -protective effects, and additionally has been involved in neurodegenerative diseases and neural disorders. Studies in Drosophila shed light on some aspects of the different levels of regulatory control of PTN invertebrate homologs. Specifically in hippocampus, recent evidence from PTN Knock-out (KO) mice involves PTN functioning in learning and memory. In this paper, we summarize, discuss, and contrast the most recent advances and results that lead to proposing a PTN as a neuromodulatory molecule in the CNS, particularly in hippocampus.http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00443/fullHippocampusNeuromodulationNeuropeptidepleiotrophinmiple |
| spellingShingle | Celia eGonzález-Castillo Daniel eOrtuño-Sahagún Carolina eGuzmán-Brambila Mercè ePalllàs Argelia Esperanza Rojas-Mayorquin Pleiotrophin as a central nervous system neuromodulator, evidences from the hippocampus Frontiers in Cellular Neuroscience Hippocampus Neuromodulation Neuropeptide pleiotrophin miple |
| title | Pleiotrophin as a central nervous system neuromodulator, evidences from the hippocampus |
| title_full | Pleiotrophin as a central nervous system neuromodulator, evidences from the hippocampus |
| title_fullStr | Pleiotrophin as a central nervous system neuromodulator, evidences from the hippocampus |
| title_full_unstemmed | Pleiotrophin as a central nervous system neuromodulator, evidences from the hippocampus |
| title_short | Pleiotrophin as a central nervous system neuromodulator, evidences from the hippocampus |
| title_sort | pleiotrophin as a central nervous system neuromodulator evidences from the hippocampus |
| topic | Hippocampus Neuromodulation Neuropeptide pleiotrophin miple |
| url | http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00443/full |
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