Human Induced Pluripotent Stem Cell-Derived Exosomes as a New Therapeutic Strategy for Various Diseases
Recently, an increasing number of studies have demonstrated that induced pluripotent stem cells (iPSCs) and iPSC-derived cells display therapeutic effects, mainly via the paracrine mechanism in addition to their transdifferentiation ability. Exosomes have emerged as an important paracrine factor for...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-02-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/4/1769 |
| _version_ | 1797411645606068224 |
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| author | Aline Yen Ling Wang |
| author_facet | Aline Yen Ling Wang |
| author_sort | Aline Yen Ling Wang |
| collection | DOAJ |
| description | Recently, an increasing number of studies have demonstrated that induced pluripotent stem cells (iPSCs) and iPSC-derived cells display therapeutic effects, mainly via the paracrine mechanism in addition to their transdifferentiation ability. Exosomes have emerged as an important paracrine factor for iPSCs to repair injured cells through the delivery of bioactive components. Animal reports of iPSC-derived exosomes on various disease models are increasing, such as in heart, limb, liver, skin, bone, eye and neurological disease and so forth. This review aims to summarize the therapeutic effects of iPSC-derived exosomes on various disease models and their properties, such as angiogenesis, cell proliferation and anti-apoptosis, with the hopes of improving their potential role in clinical applications and functional restoration. |
| first_indexed | 2024-03-09T04:48:13Z |
| format | Article |
| id | doaj.art-b75bbcbe899d40e6a5209eed1624e347 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T04:48:13Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-b75bbcbe899d40e6a5209eed1624e3472023-12-03T13:13:03ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-02-01224176910.3390/ijms22041769Human Induced Pluripotent Stem Cell-Derived Exosomes as a New Therapeutic Strategy for Various DiseasesAline Yen Ling Wang0Center for Vascularized Composite Allotransplantation, Chang Gung Memorial Hospital, 5 Fu-hsing Street, Gueishan, Taoyuan 333, TaiwanRecently, an increasing number of studies have demonstrated that induced pluripotent stem cells (iPSCs) and iPSC-derived cells display therapeutic effects, mainly via the paracrine mechanism in addition to their transdifferentiation ability. Exosomes have emerged as an important paracrine factor for iPSCs to repair injured cells through the delivery of bioactive components. Animal reports of iPSC-derived exosomes on various disease models are increasing, such as in heart, limb, liver, skin, bone, eye and neurological disease and so forth. This review aims to summarize the therapeutic effects of iPSC-derived exosomes on various disease models and their properties, such as angiogenesis, cell proliferation and anti-apoptosis, with the hopes of improving their potential role in clinical applications and functional restoration.https://www.mdpi.com/1422-0067/22/4/1769induced pluripotent stem cellsexosomecell-free regenerative medicine |
| spellingShingle | Aline Yen Ling Wang Human Induced Pluripotent Stem Cell-Derived Exosomes as a New Therapeutic Strategy for Various Diseases International Journal of Molecular Sciences induced pluripotent stem cells exosome cell-free regenerative medicine |
| title | Human Induced Pluripotent Stem Cell-Derived Exosomes as a New Therapeutic Strategy for Various Diseases |
| title_full | Human Induced Pluripotent Stem Cell-Derived Exosomes as a New Therapeutic Strategy for Various Diseases |
| title_fullStr | Human Induced Pluripotent Stem Cell-Derived Exosomes as a New Therapeutic Strategy for Various Diseases |
| title_full_unstemmed | Human Induced Pluripotent Stem Cell-Derived Exosomes as a New Therapeutic Strategy for Various Diseases |
| title_short | Human Induced Pluripotent Stem Cell-Derived Exosomes as a New Therapeutic Strategy for Various Diseases |
| title_sort | human induced pluripotent stem cell derived exosomes as a new therapeutic strategy for various diseases |
| topic | induced pluripotent stem cells exosome cell-free regenerative medicine |
| url | https://www.mdpi.com/1422-0067/22/4/1769 |
| work_keys_str_mv | AT alineyenlingwang humaninducedpluripotentstemcellderivedexosomesasanewtherapeuticstrategyforvariousdiseases |