Design and Methods of the Korean Organ Transplantation Registry
Background. Beneficial aspects of solid organ transplantation, which encompass survival benefit, improved quality of life, and cost efficacy, have been clearly demonstrated. However, regional and ethnic differences require further studies to identify prognostic factors and transplant outcomes agains...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer
2017-08-01
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| Series: | Transplantation Direct |
| Online Access: | http://journals.lww.com/transplantationdirect/fulltext/10.1097/TXD.0000000000000678 |
| _version_ | 1828368545657913344 |
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| author | Jaeseok Yang, MD, PhD Jong Cheol Jeong, MD Joongyub Lee, MD, PhD Young Hoon Kim, MD, PhD Hyo Chae Paik, MD, PhD Jae-Joong Kim, MD, PhD Hyun-young Park, MD, PhD Myoung Soo Kim, MD, PhD Curie Ahn, MD, PhD |
| author_facet | Jaeseok Yang, MD, PhD Jong Cheol Jeong, MD Joongyub Lee, MD, PhD Young Hoon Kim, MD, PhD Hyo Chae Paik, MD, PhD Jae-Joong Kim, MD, PhD Hyun-young Park, MD, PhD Myoung Soo Kim, MD, PhD Curie Ahn, MD, PhD |
| author_sort | Jaeseok Yang, MD, PhD |
| collection | DOAJ |
| description | Background. Beneficial aspects of solid organ transplantation, which encompass survival benefit, improved quality of life, and cost efficacy, have been clearly demonstrated. However, regional and ethnic differences require further studies to identify prognostic factors and transplant outcomes against various backgrounds. After previous efforts of a nationwide, retrospective study on the kidney transplant outcomes in Korea, a new prospective-designed version of the Korean Organ Transplantation Registry (KOTRY) was launched in 2014.
Methods. Cohorts of kidney, liver, heart, lung, and pancreas transplantation were developed. Data on demographics, comorbid conditions, laboratory tests, including tissue typing and panel reactive antibody tests, immunosuppressive regimen followed, concentration and dosage of immunosuppressants, allograft rejection type, infectious events, cardiovascular outcomes, malignancies, donor comorbidity, and outcomes of living donors are collected. Longitudinal data collection is based on a regular annual interval, and blood samples are collected before organ transplantation and again at 1 and 3 years posttransplantation. To enhance data quality, a predefined data verification system operates on a Web-based database, and transplant center users receive regular education about updates. Data are cleansed thrice a year, and feedback given to centers about outlier values and missing data. Annual auditing is conducted.
Results. Currently, 59 centers are participating in KOTRY. The estimated annual enrollment is more than 2000 cases.
Conclusions. KOTRY, as a systematic Korean transplant cohort, is expected to provide important information on Asian organ transplantation. The processes used to establish KOTRY provide a good model for launching new nationwide transplant cohort studies. |
| first_indexed | 2024-04-14T06:12:32Z |
| format | Article |
| id | doaj.art-b75be30b98574eed89ff23e1bdaf5cc9 |
| institution | Directory Open Access Journal |
| issn | 2373-8731 |
| language | English |
| last_indexed | 2024-04-14T06:12:32Z |
| publishDate | 2017-08-01 |
| publisher | Wolters Kluwer |
| record_format | Article |
| series | Transplantation Direct |
| spelling | doaj.art-b75be30b98574eed89ff23e1bdaf5cc92022-12-22T02:08:20ZengWolters KluwerTransplantation Direct2373-87312017-08-0138e19110.1097/TXD.0000000000000678201708000-0016Design and Methods of the Korean Organ Transplantation RegistryJaeseok Yang, MD, PhD0Jong Cheol Jeong, MD1Joongyub Lee, MD, PhD2Young Hoon Kim, MD, PhD3Hyo Chae Paik, MD, PhD4Jae-Joong Kim, MD, PhD5Hyun-young Park, MD, PhD6Myoung Soo Kim, MD, PhD7Curie Ahn, MD, PhD81 Transplantation Center, Department of Surgery, Seoul National University Hospital, Seoul, Republic of Korea.2 Department of Nephrology, Ajou University School of Medicine, Suwon, Republic of Korea.3 Medical Research Collaborating Center, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea.4 Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.5 Department of Thoracic and Cardiovascular Surgery, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.6 Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.7 Division of Cardiovascular and Rare Disease, Center for Biomedical Science, National Research Institute of Health, Centers for Disease Control and Prevention, Cheongju, Republic of Korea.8 Department of Transplant Surgery, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.9 Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea.Background. Beneficial aspects of solid organ transplantation, which encompass survival benefit, improved quality of life, and cost efficacy, have been clearly demonstrated. However, regional and ethnic differences require further studies to identify prognostic factors and transplant outcomes against various backgrounds. After previous efforts of a nationwide, retrospective study on the kidney transplant outcomes in Korea, a new prospective-designed version of the Korean Organ Transplantation Registry (KOTRY) was launched in 2014. Methods. Cohorts of kidney, liver, heart, lung, and pancreas transplantation were developed. Data on demographics, comorbid conditions, laboratory tests, including tissue typing and panel reactive antibody tests, immunosuppressive regimen followed, concentration and dosage of immunosuppressants, allograft rejection type, infectious events, cardiovascular outcomes, malignancies, donor comorbidity, and outcomes of living donors are collected. Longitudinal data collection is based on a regular annual interval, and blood samples are collected before organ transplantation and again at 1 and 3 years posttransplantation. To enhance data quality, a predefined data verification system operates on a Web-based database, and transplant center users receive regular education about updates. Data are cleansed thrice a year, and feedback given to centers about outlier values and missing data. Annual auditing is conducted. Results. Currently, 59 centers are participating in KOTRY. The estimated annual enrollment is more than 2000 cases. Conclusions. KOTRY, as a systematic Korean transplant cohort, is expected to provide important information on Asian organ transplantation. The processes used to establish KOTRY provide a good model for launching new nationwide transplant cohort studies.http://journals.lww.com/transplantationdirect/fulltext/10.1097/TXD.0000000000000678 |
| spellingShingle | Jaeseok Yang, MD, PhD Jong Cheol Jeong, MD Joongyub Lee, MD, PhD Young Hoon Kim, MD, PhD Hyo Chae Paik, MD, PhD Jae-Joong Kim, MD, PhD Hyun-young Park, MD, PhD Myoung Soo Kim, MD, PhD Curie Ahn, MD, PhD Design and Methods of the Korean Organ Transplantation Registry Transplantation Direct |
| title | Design and Methods of the Korean Organ Transplantation Registry |
| title_full | Design and Methods of the Korean Organ Transplantation Registry |
| title_fullStr | Design and Methods of the Korean Organ Transplantation Registry |
| title_full_unstemmed | Design and Methods of the Korean Organ Transplantation Registry |
| title_short | Design and Methods of the Korean Organ Transplantation Registry |
| title_sort | design and methods of the korean organ transplantation registry |
| url | http://journals.lww.com/transplantationdirect/fulltext/10.1097/TXD.0000000000000678 |
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