Are BCG-induced non-specific effects adequate to provide protection against COVID-19?
The world is experiencing a pandemic of Coronavirus Disease (COVID-19) caused by type-2 Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2). Vaccination is the only option to prevent future surges of the disease. Efforts for developing an effective vaccine are underway, but the timeline for t...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2021-01-01
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| Series: | Human Vaccines & Immunotherapeutics |
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| Online Access: | http://dx.doi.org/10.1080/21645515.2020.1794219 |
| _version_ | 1797633737894133760 |
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| author | Vipin M. Vashishtha |
| author_facet | Vipin M. Vashishtha |
| author_sort | Vipin M. Vashishtha |
| collection | DOAJ |
| description | The world is experiencing a pandemic of Coronavirus Disease (COVID-19) caused by type-2 Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2). Vaccination is the only option to prevent future surges of the disease. Efforts for developing an effective vaccine are underway, but the timeline for the widespread availability of safe and effective vaccines is unknown. Some ecological reports have linked regional universal use of the Bacillus Calmette-Guerin (BCG) vaccine with reduced morbidity and mortality of COVID-19. BCG protects from non-tuberculous diseases through ‘non-specific’ effects mediated by the modulation of innate immunity. This commentary provides details of the immunological mechanism of BCG-induced ‘trained innate immunity’ responsible for its nonspecific protective effects. A probable role of the BCG vaccine in the current pandemic is also examined. |
| first_indexed | 2024-03-11T11:58:04Z |
| format | Article |
| id | doaj.art-b75c950fd1544315b21d33ee4241b5de |
| institution | Directory Open Access Journal |
| issn | 2164-5515 2164-554X |
| language | English |
| last_indexed | 2024-03-11T11:58:04Z |
| publishDate | 2021-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj.art-b75c950fd1544315b21d33ee4241b5de2023-11-08T11:55:20ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2021-01-01171889110.1080/21645515.2020.17942191794219Are BCG-induced non-specific effects adequate to provide protection against COVID-19?Vipin M. Vashishtha0Mangla Hospital & Research CenterThe world is experiencing a pandemic of Coronavirus Disease (COVID-19) caused by type-2 Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2). Vaccination is the only option to prevent future surges of the disease. Efforts for developing an effective vaccine are underway, but the timeline for the widespread availability of safe and effective vaccines is unknown. Some ecological reports have linked regional universal use of the Bacillus Calmette-Guerin (BCG) vaccine with reduced morbidity and mortality of COVID-19. BCG protects from non-tuberculous diseases through ‘non-specific’ effects mediated by the modulation of innate immunity. This commentary provides details of the immunological mechanism of BCG-induced ‘trained innate immunity’ responsible for its nonspecific protective effects. A probable role of the BCG vaccine in the current pandemic is also examined.http://dx.doi.org/10.1080/21645515.2020.1794219coronavirus diseasesars-cov-2bacillus calmette-guerin (bcg) vaccinenonspecific effectstrained innate immunity |
| spellingShingle | Vipin M. Vashishtha Are BCG-induced non-specific effects adequate to provide protection against COVID-19? Human Vaccines & Immunotherapeutics coronavirus disease sars-cov-2 bacillus calmette-guerin (bcg) vaccine nonspecific effects trained innate immunity |
| title | Are BCG-induced non-specific effects adequate to provide protection against COVID-19? |
| title_full | Are BCG-induced non-specific effects adequate to provide protection against COVID-19? |
| title_fullStr | Are BCG-induced non-specific effects adequate to provide protection against COVID-19? |
| title_full_unstemmed | Are BCG-induced non-specific effects adequate to provide protection against COVID-19? |
| title_short | Are BCG-induced non-specific effects adequate to provide protection against COVID-19? |
| title_sort | are bcg induced non specific effects adequate to provide protection against covid 19 |
| topic | coronavirus disease sars-cov-2 bacillus calmette-guerin (bcg) vaccine nonspecific effects trained innate immunity |
| url | http://dx.doi.org/10.1080/21645515.2020.1794219 |
| work_keys_str_mv | AT vipinmvashishtha arebcginducednonspecificeffectsadequatetoprovideprotectionagainstcovid19 |