Effect of zolpidem on functional recovery in a rat model of ischemic stroke
Objective To evaluate the effects of zolpidem on functional recovery in a rat model of acute ischemic stroke. Methods Following ischemic stroke procedures, 42 rats (six in each group) were randomly assigned to receive zolpidem (0.1, 0.25, 0.5, 1.0, 2.0 or 4.0 mg/kg) or normal saline administer intra...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2018-01-01
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| Series: | Journal of International Medical Research |
| Online Access: | https://doi.org/10.1177/0300060517723799 |
| _version_ | 1818898483250200576 |
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| author | Min-Kyun Oh Kyung Jae Yoon Yong-Taek Lee Seoung Wan Chae Hye Young Choi Hee Suk Shin Yun Hee Park Se-Woong Chun Young Sook Park |
| author_facet | Min-Kyun Oh Kyung Jae Yoon Yong-Taek Lee Seoung Wan Chae Hye Young Choi Hee Suk Shin Yun Hee Park Se-Woong Chun Young Sook Park |
| author_sort | Min-Kyun Oh |
| collection | DOAJ |
| description | Objective To evaluate the effects of zolpidem on functional recovery in a rat model of acute ischemic stroke. Methods Following ischemic stroke procedures, 42 rats (six in each group) were randomly assigned to receive zolpidem (0.1, 0.25, 0.5, 1.0, 2.0 or 4.0 mg/kg) or normal saline administer intraperitoneally once daily for two weeks. Motor behavioural index (MBI) scores, radial 8-arm maze (RAM) test times and brain MRI scans were obtained 24 hours (Day 1) and two weeks (Day 14) post-procedure. Immunohistochemistry was performed on Day 14. Results By comparison with the normal saline group, the 0.5 and 1.0 mg/kg zolpidem groups showed statistically significant improvements in MBI scores and increased numbers of brain-derived neurotrophic factor (BDNF) stained cells over the two week dosing period. By contrast, the 4.0 mg/kg zolpidem group had statistically significantly impaired MBI scores compared with the control group. No differences among groups were found in RAM times or infarction volumes. Conclusions This study in a rat model showed that 0.5–1.0 mg/kg of zolpidem had beneficial effects on behavioural recovery by enhancing neural plasticity without causing any memory impairment in acute ischemic stroke. |
| first_indexed | 2024-12-19T19:32:47Z |
| format | Article |
| id | doaj.art-b75de6aa22b24c03a8d69b12868011ac |
| institution | Directory Open Access Journal |
| issn | 0300-0605 1473-2300 |
| language | English |
| last_indexed | 2024-12-19T19:32:47Z |
| publishDate | 2018-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of International Medical Research |
| spelling | doaj.art-b75de6aa22b24c03a8d69b12868011ac2022-12-21T20:08:33ZengSAGE PublishingJournal of International Medical Research0300-06051473-23002018-01-014610.1177/0300060517723799Effect of zolpidem on functional recovery in a rat model of ischemic strokeMin-Kyun Oh0Kyung Jae Yoon1Yong-Taek Lee2Seoung Wan Chae3Hye Young Choi4Hee Suk Shin5Yun Hee Park6Se-Woong Chun7Young Sook Park8Department of Rehabilitation Medicine, Gyeongsang National University Changwon Hospital, Gyeongsang National University School of Medicine, Changwon, Republic of KoreaMedical Research Institute, Regenerative & Neuroscience laboratory, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of KoreaMedical Research Institute, Regenerative & Neuroscience laboratory, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of KoreaDepartment of Pathology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of KoreaDepartment of Radiology, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine, Jinju, Republic of KoreaDepartment of Rehabilitation Medicine, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine, Jinju, Republic of KoreaDepartment of Physical Medicine & Rehabilitation, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Republic of KoreaDepartment of Rehabilitation Medicine, Gyeongsang National University Changwon Hospital, Gyeongsang National University School of Medicine, Changwon, Republic of KoreaDepartment of Physical Medicine & Rehabilitation, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Republic of KoreaObjective To evaluate the effects of zolpidem on functional recovery in a rat model of acute ischemic stroke. Methods Following ischemic stroke procedures, 42 rats (six in each group) were randomly assigned to receive zolpidem (0.1, 0.25, 0.5, 1.0, 2.0 or 4.0 mg/kg) or normal saline administer intraperitoneally once daily for two weeks. Motor behavioural index (MBI) scores, radial 8-arm maze (RAM) test times and brain MRI scans were obtained 24 hours (Day 1) and two weeks (Day 14) post-procedure. Immunohistochemistry was performed on Day 14. Results By comparison with the normal saline group, the 0.5 and 1.0 mg/kg zolpidem groups showed statistically significant improvements in MBI scores and increased numbers of brain-derived neurotrophic factor (BDNF) stained cells over the two week dosing period. By contrast, the 4.0 mg/kg zolpidem group had statistically significantly impaired MBI scores compared with the control group. No differences among groups were found in RAM times or infarction volumes. Conclusions This study in a rat model showed that 0.5–1.0 mg/kg of zolpidem had beneficial effects on behavioural recovery by enhancing neural plasticity without causing any memory impairment in acute ischemic stroke.https://doi.org/10.1177/0300060517723799 |
| spellingShingle | Min-Kyun Oh Kyung Jae Yoon Yong-Taek Lee Seoung Wan Chae Hye Young Choi Hee Suk Shin Yun Hee Park Se-Woong Chun Young Sook Park Effect of zolpidem on functional recovery in a rat model of ischemic stroke Journal of International Medical Research |
| title | Effect of zolpidem on functional recovery in a rat model of ischemic stroke |
| title_full | Effect of zolpidem on functional recovery in a rat model of ischemic stroke |
| title_fullStr | Effect of zolpidem on functional recovery in a rat model of ischemic stroke |
| title_full_unstemmed | Effect of zolpidem on functional recovery in a rat model of ischemic stroke |
| title_short | Effect of zolpidem on functional recovery in a rat model of ischemic stroke |
| title_sort | effect of zolpidem on functional recovery in a rat model of ischemic stroke |
| url | https://doi.org/10.1177/0300060517723799 |
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