Unexpected findings of hepatitis B and delta infection in northeastern Brazil: A public health alert
Introduction and objectives: Research has shown that hepatitis B (HBV) and Delta virus (HDV) are a worldwide public health problem. This study aims to estimate the prevalence rates of HBV and HDV infection in five municipalities of Maranhão, Northeastern Brazil. Materials and methods: A total sample...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-05-01
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| Series: | Annals of Hepatology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1665268120301873 |
| _version_ | 1818639690705666048 |
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| author | Jomar Diogo Costa Nunes Diego Luz Felipe da Silva Lena Maria Barros Fonseca Ilana Mirian Almeida Felipe Beatriz Rossetti Ferreira Rodrigo de Carvalho Santana Ana de Lourdes Candolo Martinelli Antônio Augusto Moura da Silva João Renato Rebello Pinho Michele Soares Gomes Gouvêa Max Diego Cruz Santos Thais Feres Moreira Lima Ingrid de Campos Albuquerque Marinilde Teles Souza Maria Josélia Diniz Moraes Arlene de Jesus Mendes Caldas Letícia Alana Barros Souza Camila Maria Pinheiro de Mello e Silva Adalgisa de Souza Paiva Ferreira |
| author_facet | Jomar Diogo Costa Nunes Diego Luz Felipe da Silva Lena Maria Barros Fonseca Ilana Mirian Almeida Felipe Beatriz Rossetti Ferreira Rodrigo de Carvalho Santana Ana de Lourdes Candolo Martinelli Antônio Augusto Moura da Silva João Renato Rebello Pinho Michele Soares Gomes Gouvêa Max Diego Cruz Santos Thais Feres Moreira Lima Ingrid de Campos Albuquerque Marinilde Teles Souza Maria Josélia Diniz Moraes Arlene de Jesus Mendes Caldas Letícia Alana Barros Souza Camila Maria Pinheiro de Mello e Silva Adalgisa de Souza Paiva Ferreira |
| author_sort | Jomar Diogo Costa Nunes |
| collection | DOAJ |
| description | Introduction and objectives: Research has shown that hepatitis B (HBV) and Delta virus (HDV) are a worldwide public health problem. This study aims to estimate the prevalence rates of HBV and HDV infection in five municipalities of Maranhão, Northeastern Brazil. Materials and methods: A total sample between 3856 and 4000 individuals. Questionnaires were used to register sociodemographic characteristics and factors associated with transmission. Patients were tested for hepatitis B virus surface antigen (HBsAg), anti-hepatitis B core antigen (anti-HBc), and antibodies against hepatitis Delta virus (anti-HDV). Factors associated with HBV were detected by means of multivariate Poisson regression. Results: Overall, 3983 subjects were included. Ninety-two of the participants were HBsAg-positive (2.30%, 95% CI 1.80–2.80), and anti-HBc was detected in 1535 (38.50%, 95% CI 37–40). The factors associated with the presence of anti-HBc were: (1) Municipality (P < 0.001); Age (P < 0.001); School education (P < 0.001); Illicit drug use (P = 0.001); non-HBV vaccine (P = 0.041). Among the HBsAg carriers, eight were anti-HDV-positive (8.69%, 95% CI 2.90–14.40). The most frequent HBV genotype was D4. The only HDV genotype was HDV-8. Conclusion: HBV exhibited intermediate endemicity in the studied region. Traditional factors were associated with exposure to the virus. The presence of the HDV was confirmed. The most frequent HBV and HDV genotypes were unlike the ones currently described in Brazil. |
| first_indexed | 2024-12-16T22:59:23Z |
| format | Article |
| id | doaj.art-b75e7a3b53ac472685c024a9bbb9c4e5 |
| institution | Directory Open Access Journal |
| issn | 1665-2681 |
| language | English |
| last_indexed | 2024-12-16T22:59:23Z |
| publishDate | 2021-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Annals of Hepatology |
| spelling | doaj.art-b75e7a3b53ac472685c024a9bbb9c4e52022-12-21T22:12:47ZengElsevierAnnals of Hepatology1665-26812021-05-0122100272Unexpected findings of hepatitis B and delta infection in northeastern Brazil: A public health alertJomar Diogo Costa Nunes0Diego Luz Felipe da Silva1Lena Maria Barros Fonseca2Ilana Mirian Almeida Felipe3Beatriz Rossetti Ferreira4Rodrigo de Carvalho Santana5Ana de Lourdes Candolo Martinelli6Antônio Augusto Moura da Silva7João Renato Rebello Pinho8Michele Soares Gomes Gouvêa9Max Diego Cruz Santos10Thais Feres Moreira Lima11Ingrid de Campos Albuquerque12Marinilde Teles Souza13Maria Josélia Diniz Moraes14Arlene de Jesus Mendes Caldas15Letícia Alana Barros Souza16Camila Maria Pinheiro de Mello e Silva17Adalgisa de Souza Paiva Ferreira18Graduate Program of Health Sciences, Federal University of Maranhão, Maranhão, Brazil; Corresponding author.Federal University of Maranhão, Maranhão, BrazilDepartment of Nursing, Federal University of Maranhão, Maranhão, BrazilFederal University of Maranhão, University College, São Luís, Maranhão, BrazilCollege of Nursing, Departament of Maternal-Infant Nursing and Public Health, Ribeirão Preto, São Paulo, BrazilDivision of Infectious Disease, Department of Internal Medicine, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, BrazilDepartment of Medicine Division of Gastroenterology Faculty of Medicine of Ribeirão Preto, University of São Paulo, BrazilDepartment of Public Health, Federal University of Maranhão, São Luís, MA, BrazilLaboratory of Tropical Gastroenterology and Hepatology “João Alves de Queiroz and Castorina Bittencourt Alves”, LIM-07, São Paulo Institute of Tropical Medicine and Department of Gastroenterology, School of Medicine, University of São Paulo, São Paulo, SP, Brazil; Hospital Israelita Albert Einstein, São Paulo, SP, BrazilLaboratory of Tropical Gastroenterology and Hepatology “João Alves de Queiroz and Castorina Bittencourt Alves”, LIM-07, São Paulo Institute of Tropical Medicine and Department of Gastroenterology, School of Medicine, University of São Paulo, São Paulo, SP, Brazil; Hospital Israelita Albert Einstein, São Paulo, SP, BrazilFederal University of Maranhão, Maranhão, BrazilFederal University of Maranhão, Maranhão, BrazilFederal University of Maranhão, Maranhão, BrazilFederal University of Maranhão, Maranhão, BrazilMaranhão Clinical Research Center, University Hospital of the Federal University of Maranhão, Maranhão, BrazilDepartment of Nursing, Federal University of Maranhão, Maranhão, BrazilFederal University of Maranhão, Maranhão, BrazilGraduate Program of Nursing, Federal University of Maranhão, Maranhão, BrazilDepartment of Medicine, Federal University of Maranhão, Maranhão, BrazilIntroduction and objectives: Research has shown that hepatitis B (HBV) and Delta virus (HDV) are a worldwide public health problem. This study aims to estimate the prevalence rates of HBV and HDV infection in five municipalities of Maranhão, Northeastern Brazil. Materials and methods: A total sample between 3856 and 4000 individuals. Questionnaires were used to register sociodemographic characteristics and factors associated with transmission. Patients were tested for hepatitis B virus surface antigen (HBsAg), anti-hepatitis B core antigen (anti-HBc), and antibodies against hepatitis Delta virus (anti-HDV). Factors associated with HBV were detected by means of multivariate Poisson regression. Results: Overall, 3983 subjects were included. Ninety-two of the participants were HBsAg-positive (2.30%, 95% CI 1.80–2.80), and anti-HBc was detected in 1535 (38.50%, 95% CI 37–40). The factors associated with the presence of anti-HBc were: (1) Municipality (P < 0.001); Age (P < 0.001); School education (P < 0.001); Illicit drug use (P = 0.001); non-HBV vaccine (P = 0.041). Among the HBsAg carriers, eight were anti-HDV-positive (8.69%, 95% CI 2.90–14.40). The most frequent HBV genotype was D4. The only HDV genotype was HDV-8. Conclusion: HBV exhibited intermediate endemicity in the studied region. Traditional factors were associated with exposure to the virus. The presence of the HDV was confirmed. The most frequent HBV and HDV genotypes were unlike the ones currently described in Brazil.http://www.sciencedirect.com/science/article/pii/S1665268120301873Hepatitis BHealth impact assessmentHealth policy |
| spellingShingle | Jomar Diogo Costa Nunes Diego Luz Felipe da Silva Lena Maria Barros Fonseca Ilana Mirian Almeida Felipe Beatriz Rossetti Ferreira Rodrigo de Carvalho Santana Ana de Lourdes Candolo Martinelli Antônio Augusto Moura da Silva João Renato Rebello Pinho Michele Soares Gomes Gouvêa Max Diego Cruz Santos Thais Feres Moreira Lima Ingrid de Campos Albuquerque Marinilde Teles Souza Maria Josélia Diniz Moraes Arlene de Jesus Mendes Caldas Letícia Alana Barros Souza Camila Maria Pinheiro de Mello e Silva Adalgisa de Souza Paiva Ferreira Unexpected findings of hepatitis B and delta infection in northeastern Brazil: A public health alert Annals of Hepatology Hepatitis B Health impact assessment Health policy |
| title | Unexpected findings of hepatitis B and delta infection in northeastern Brazil: A public health alert |
| title_full | Unexpected findings of hepatitis B and delta infection in northeastern Brazil: A public health alert |
| title_fullStr | Unexpected findings of hepatitis B and delta infection in northeastern Brazil: A public health alert |
| title_full_unstemmed | Unexpected findings of hepatitis B and delta infection in northeastern Brazil: A public health alert |
| title_short | Unexpected findings of hepatitis B and delta infection in northeastern Brazil: A public health alert |
| title_sort | unexpected findings of hepatitis b and delta infection in northeastern brazil a public health alert |
| topic | Hepatitis B Health impact assessment Health policy |
| url | http://www.sciencedirect.com/science/article/pii/S1665268120301873 |
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