Biodegradable polyphosphoester micelles act as both background-free 31P magnetic resonance imaging agents and drug nanocarriers
Abstract In vivo monitoring of polymers is crucial for drug delivery and tissue regeneration. Magnetic resonance imaging (MRI) is a whole-body imaging technique, and heteronuclear MRI allows quantitative imaging. However, MRI agents can result in environmental pollution and organ accumulation. To ad...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-40089-0 |
| _version_ | 1797774105807683584 |
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| author | Olga Koshkina Timo Rheinberger Vera Flocke Anton Windfelder Pascal Bouvain Naomi M. Hamelmann Jos M. J. Paulusse Hubert Gojzewski Ulrich Flögel Frederik R. Wurm |
| author_facet | Olga Koshkina Timo Rheinberger Vera Flocke Anton Windfelder Pascal Bouvain Naomi M. Hamelmann Jos M. J. Paulusse Hubert Gojzewski Ulrich Flögel Frederik R. Wurm |
| author_sort | Olga Koshkina |
| collection | DOAJ |
| description | Abstract In vivo monitoring of polymers is crucial for drug delivery and tissue regeneration. Magnetic resonance imaging (MRI) is a whole-body imaging technique, and heteronuclear MRI allows quantitative imaging. However, MRI agents can result in environmental pollution and organ accumulation. To address this, we introduce biocompatible and biodegradable polyphosphoesters, as MRI-traceable polymers using the 31P centers in the polymer backbone. We overcome challenges in 31P MRI, including background interference and low sensitivity, by modifying the molecular environment of 31P, assembling polymers into colloids, and tailoring the polymers’ microstructure to adjust MRI-relaxation times. Specifically, gradient-type polyphosphonate-copolymers demonstrate improved MRI-relaxation times compared to homo- and block copolymers, making them suitable for imaging. We validate background-free imaging and biodegradation in vivo using Manduca sexta. Furthermore, encapsulating the potent drug PROTAC allows using these amphiphilic copolymers to simultaneously deliver drugs, enabling theranostics. This first report paves the way for polyphosphoesters as background-free MRI-traceable polymers for theranostic applications. |
| first_indexed | 2024-03-12T22:16:12Z |
| format | Article |
| id | doaj.art-b75f7cdd54b44b0f9a06bafc9275d94e |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-03-12T22:16:12Z |
| publishDate | 2023-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-b75f7cdd54b44b0f9a06bafc9275d94e2023-07-23T11:19:27ZengNature PortfolioNature Communications2041-17232023-07-011411810.1038/s41467-023-40089-0Biodegradable polyphosphoester micelles act as both background-free 31P magnetic resonance imaging agents and drug nanocarriersOlga Koshkina0Timo Rheinberger1Vera Flocke2Anton Windfelder3Pascal Bouvain4Naomi M. Hamelmann5Jos M. J. Paulusse6Hubert Gojzewski7Ulrich Flögel8Frederik R. Wurm9Sustainable Polymer Chemistry Group, Department of Molecules and Materials, MESA+ Institute of Nanotechnology, Faculty of Science and Technology, University of TwenteSustainable Polymer Chemistry Group, Department of Molecules and Materials, MESA+ Institute of Nanotechnology, Faculty of Science and Technology, University of TwenteDepartment of Molecular Cardiology, Experimental Cardiovascular Imaging, Heinrich Heine UniversityDepartment of Bioresources, Fraunhofer Institute for Molecular Biology and Applied Ecology IMEDepartment of Molecular Cardiology, Experimental Cardiovascular Imaging, Heinrich Heine UniversityBiomolecular Nanotechnology Group, Department of Molecules and Materials, MESA+ Institute of Nanotechnology, University of TwenteBiomolecular Nanotechnology Group, Department of Molecules and Materials, MESA+ Institute of Nanotechnology, University of TwenteSustainable Polymer Chemistry Group, Department of Molecules and Materials, MESA+ Institute of Nanotechnology, Faculty of Science and Technology, University of TwenteDepartment of Molecular Cardiology, Experimental Cardiovascular Imaging, Heinrich Heine UniversitySustainable Polymer Chemistry Group, Department of Molecules and Materials, MESA+ Institute of Nanotechnology, Faculty of Science and Technology, University of TwenteAbstract In vivo monitoring of polymers is crucial for drug delivery and tissue regeneration. Magnetic resonance imaging (MRI) is a whole-body imaging technique, and heteronuclear MRI allows quantitative imaging. However, MRI agents can result in environmental pollution and organ accumulation. To address this, we introduce biocompatible and biodegradable polyphosphoesters, as MRI-traceable polymers using the 31P centers in the polymer backbone. We overcome challenges in 31P MRI, including background interference and low sensitivity, by modifying the molecular environment of 31P, assembling polymers into colloids, and tailoring the polymers’ microstructure to adjust MRI-relaxation times. Specifically, gradient-type polyphosphonate-copolymers demonstrate improved MRI-relaxation times compared to homo- and block copolymers, making them suitable for imaging. We validate background-free imaging and biodegradation in vivo using Manduca sexta. Furthermore, encapsulating the potent drug PROTAC allows using these amphiphilic copolymers to simultaneously deliver drugs, enabling theranostics. This first report paves the way for polyphosphoesters as background-free MRI-traceable polymers for theranostic applications.https://doi.org/10.1038/s41467-023-40089-0 |
| spellingShingle | Olga Koshkina Timo Rheinberger Vera Flocke Anton Windfelder Pascal Bouvain Naomi M. Hamelmann Jos M. J. Paulusse Hubert Gojzewski Ulrich Flögel Frederik R. Wurm Biodegradable polyphosphoester micelles act as both background-free 31P magnetic resonance imaging agents and drug nanocarriers Nature Communications |
| title | Biodegradable polyphosphoester micelles act as both background-free 31P magnetic resonance imaging agents and drug nanocarriers |
| title_full | Biodegradable polyphosphoester micelles act as both background-free 31P magnetic resonance imaging agents and drug nanocarriers |
| title_fullStr | Biodegradable polyphosphoester micelles act as both background-free 31P magnetic resonance imaging agents and drug nanocarriers |
| title_full_unstemmed | Biodegradable polyphosphoester micelles act as both background-free 31P magnetic resonance imaging agents and drug nanocarriers |
| title_short | Biodegradable polyphosphoester micelles act as both background-free 31P magnetic resonance imaging agents and drug nanocarriers |
| title_sort | biodegradable polyphosphoester micelles act as both background free 31p magnetic resonance imaging agents and drug nanocarriers |
| url | https://doi.org/10.1038/s41467-023-40089-0 |
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