Age- and refraction-related changes in anterior segment anatomical structures measured by swept-source anterior segment OCT.
<h4>Purpose</h4>To assess the effects of age and refractive status on anterior segment anatomical structures, including the ciliary body, using a new swept-source anterior segment optical coherence tomography (AS-OCT) device.<h4>Methods</h4>This prospective observational stud...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2020-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0240110 |
| _version_ | 1819122805413773312 |
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| author | Xiaobin Xie Giulia Corradetti Abe Song Anmol Pardeshi William Sultan Jong Yeon Lee Fei Yu Lixia Zhang Shuang Chen Vikas Chopra Srinivas R Sadda Benjamin Xu Alex S Huang |
| author_facet | Xiaobin Xie Giulia Corradetti Abe Song Anmol Pardeshi William Sultan Jong Yeon Lee Fei Yu Lixia Zhang Shuang Chen Vikas Chopra Srinivas R Sadda Benjamin Xu Alex S Huang |
| author_sort | Xiaobin Xie |
| collection | DOAJ |
| description | <h4>Purpose</h4>To assess the effects of age and refractive status on anterior segment anatomical structures, including the ciliary body, using a new swept-source anterior segment optical coherence tomography (AS-OCT) device.<h4>Methods</h4>This prospective observational study included 63 healthy volunteers (mean age: 44.2 years). Images of the anterior segment were obtained using a new swept-source AS-OCT (ANTERION, Heidelberg Engineering GmbH, Heidelberg, Germany) with tracking and image averaging from the right eye of all participants. Repeatability as well as inter- and intra-observer reliability of biometric measurements were evaluated. The impact of image tracking and averaging on ciliary muscle measurements was tested. Univariate and multivariable statistical models were developed to evaluate the relationship of age and refractive status on anterior segment biometric measurements.<h4>Results</h4>For all test-retest repeatability and inter- and intra-observer reproducibility of swept-source AS-OCT measurements, high intraclass correlation (ICC) was noted (0.88-1.00). The nasal maximum ciliary muscle thickness (CMTMAX) and distance between scleral spur to the thickest point of the ciliary muscle (SSMAX) were larger than those on the temporal side (p<0.001 and p = 0.006, respectively). Nasal and temporal CMTMAX (p = 0.004 and p<0.001, respectively) and lens thickness (p<0.01) increased with age. Nasal and temporal SSMAX decreased with older age and increasing hyperopia (p = 0.01 and p<0.001, respectively). Image averaging resulted in improved ciliary muscle measurements (p = 0.008 to 0.02). Lens vault increased with older age and increased hyperopia (p<0.01). OCT measurements of the angle decreased with older age and increased hyperopia (p<0.001 to 0.03). Aqueous depth decreased with older age and increased hyperopia (p<0.01). Pupil diameter decreased with older age (p<0.01).<h4>Conclusions</h4>Repeatability and reproducibility of biometric measurements using the ANTERION AS-OCT were excellent. Image averaging improved the accuracy of ciliary muscle measurements. The device produced measurements of biometric parameters that described superficial and deep structures including the ciliary body and full lens thickness from a single image. |
| first_indexed | 2024-12-22T06:58:17Z |
| format | Article |
| id | doaj.art-b761e63235a04d31adf052a0a95cb814 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-22T06:58:17Z |
| publishDate | 2020-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj.art-b761e63235a04d31adf052a0a95cb8142022-12-21T18:34:52ZengPublic Library of Science (PLoS)PLoS ONE1932-62032020-01-011510e024011010.1371/journal.pone.0240110Age- and refraction-related changes in anterior segment anatomical structures measured by swept-source anterior segment OCT.Xiaobin XieGiulia CorradettiAbe SongAnmol PardeshiWilliam SultanJong Yeon LeeFei YuLixia ZhangShuang ChenVikas ChopraSrinivas R SaddaBenjamin XuAlex S Huang<h4>Purpose</h4>To assess the effects of age and refractive status on anterior segment anatomical structures, including the ciliary body, using a new swept-source anterior segment optical coherence tomography (AS-OCT) device.<h4>Methods</h4>This prospective observational study included 63 healthy volunteers (mean age: 44.2 years). Images of the anterior segment were obtained using a new swept-source AS-OCT (ANTERION, Heidelberg Engineering GmbH, Heidelberg, Germany) with tracking and image averaging from the right eye of all participants. Repeatability as well as inter- and intra-observer reliability of biometric measurements were evaluated. The impact of image tracking and averaging on ciliary muscle measurements was tested. Univariate and multivariable statistical models were developed to evaluate the relationship of age and refractive status on anterior segment biometric measurements.<h4>Results</h4>For all test-retest repeatability and inter- and intra-observer reproducibility of swept-source AS-OCT measurements, high intraclass correlation (ICC) was noted (0.88-1.00). The nasal maximum ciliary muscle thickness (CMTMAX) and distance between scleral spur to the thickest point of the ciliary muscle (SSMAX) were larger than those on the temporal side (p<0.001 and p = 0.006, respectively). Nasal and temporal CMTMAX (p = 0.004 and p<0.001, respectively) and lens thickness (p<0.01) increased with age. Nasal and temporal SSMAX decreased with older age and increasing hyperopia (p = 0.01 and p<0.001, respectively). Image averaging resulted in improved ciliary muscle measurements (p = 0.008 to 0.02). Lens vault increased with older age and increased hyperopia (p<0.01). OCT measurements of the angle decreased with older age and increased hyperopia (p<0.001 to 0.03). Aqueous depth decreased with older age and increased hyperopia (p<0.01). Pupil diameter decreased with older age (p<0.01).<h4>Conclusions</h4>Repeatability and reproducibility of biometric measurements using the ANTERION AS-OCT were excellent. Image averaging improved the accuracy of ciliary muscle measurements. The device produced measurements of biometric parameters that described superficial and deep structures including the ciliary body and full lens thickness from a single image.https://doi.org/10.1371/journal.pone.0240110 |
| spellingShingle | Xiaobin Xie Giulia Corradetti Abe Song Anmol Pardeshi William Sultan Jong Yeon Lee Fei Yu Lixia Zhang Shuang Chen Vikas Chopra Srinivas R Sadda Benjamin Xu Alex S Huang Age- and refraction-related changes in anterior segment anatomical structures measured by swept-source anterior segment OCT. PLoS ONE |
| title | Age- and refraction-related changes in anterior segment anatomical structures measured by swept-source anterior segment OCT. |
| title_full | Age- and refraction-related changes in anterior segment anatomical structures measured by swept-source anterior segment OCT. |
| title_fullStr | Age- and refraction-related changes in anterior segment anatomical structures measured by swept-source anterior segment OCT. |
| title_full_unstemmed | Age- and refraction-related changes in anterior segment anatomical structures measured by swept-source anterior segment OCT. |
| title_short | Age- and refraction-related changes in anterior segment anatomical structures measured by swept-source anterior segment OCT. |
| title_sort | age and refraction related changes in anterior segment anatomical structures measured by swept source anterior segment oct |
| url | https://doi.org/10.1371/journal.pone.0240110 |
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