β-Lactam Resistance in ESKAPE Pathogens Mediated Through Modifications in Penicillin-Binding Proteins: An Overview
Abstract Bacteria acquire β-lactam resistance through a multitude of mechanisms among which production of β-lactamases (enzymes that hydrolyze β-lactams) is the most common, especially in Gram-negatives. Structural changes in the high-molecular-weight, essential penicillin-binding proteins (PBPs) ar...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Adis, Springer Healthcare
2023-03-01
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| Series: | Infectious Diseases and Therapy |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/s40121-023-00771-8 |
| _version_ | 1797863966115889152 |
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| author | Dhiviya Prabaa Muthuirulandi Sethuvel Yamuna Devi Bakthavatchalam Maruthan Karthik Madhumathi Irulappan Rahul Shrivastava Hariharan Periasamy Balaji Veeraraghavan |
| author_facet | Dhiviya Prabaa Muthuirulandi Sethuvel Yamuna Devi Bakthavatchalam Maruthan Karthik Madhumathi Irulappan Rahul Shrivastava Hariharan Periasamy Balaji Veeraraghavan |
| author_sort | Dhiviya Prabaa Muthuirulandi Sethuvel |
| collection | DOAJ |
| description | Abstract Bacteria acquire β-lactam resistance through a multitude of mechanisms among which production of β-lactamases (enzymes that hydrolyze β-lactams) is the most common, especially in Gram-negatives. Structural changes in the high-molecular-weight, essential penicillin-binding proteins (PBPs) are widespread in Gram-positives and increasingly reported in Gram-negatives. PBP-mediated resistance is largely achieved by accumulation of mutation(s) resulting in reduced binding affinities of β-lactams. Herein, we discuss PBP-mediated resistance among ESKAPE pathogens that cause diverse hospital- and community-acquired infections globally. |
| first_indexed | 2024-04-09T22:45:11Z |
| format | Article |
| id | doaj.art-b762f3cd6f254fc9a2016e579bab37d7 |
| institution | Directory Open Access Journal |
| issn | 2193-8229 2193-6382 |
| language | English |
| last_indexed | 2024-04-09T22:45:11Z |
| publishDate | 2023-03-01 |
| publisher | Adis, Springer Healthcare |
| record_format | Article |
| series | Infectious Diseases and Therapy |
| spelling | doaj.art-b762f3cd6f254fc9a2016e579bab37d72023-03-22T11:56:20ZengAdis, Springer HealthcareInfectious Diseases and Therapy2193-82292193-63822023-03-0112382984110.1007/s40121-023-00771-8β-Lactam Resistance in ESKAPE Pathogens Mediated Through Modifications in Penicillin-Binding Proteins: An OverviewDhiviya Prabaa Muthuirulandi Sethuvel0Yamuna Devi Bakthavatchalam1Maruthan Karthik2Madhumathi Irulappan3Rahul Shrivastava4Hariharan Periasamy5Balaji Veeraraghavan6Department of Clinical Microbiology, Christian Medical CollegeDepartment of Clinical Microbiology, Christian Medical CollegeDepartment of Clinical Microbiology, Christian Medical CollegeDepartment of Clinical Microbiology, Christian Medical CollegeWockhardt Research CentreWockhardt Research CentreDepartment of Clinical Microbiology, Christian Medical CollegeAbstract Bacteria acquire β-lactam resistance through a multitude of mechanisms among which production of β-lactamases (enzymes that hydrolyze β-lactams) is the most common, especially in Gram-negatives. Structural changes in the high-molecular-weight, essential penicillin-binding proteins (PBPs) are widespread in Gram-positives and increasingly reported in Gram-negatives. PBP-mediated resistance is largely achieved by accumulation of mutation(s) resulting in reduced binding affinities of β-lactams. Herein, we discuss PBP-mediated resistance among ESKAPE pathogens that cause diverse hospital- and community-acquired infections globally.https://doi.org/10.1007/s40121-023-00771-8PBPESKAPEResistanceβ-LactamAntibioticPeptidoglycan |
| spellingShingle | Dhiviya Prabaa Muthuirulandi Sethuvel Yamuna Devi Bakthavatchalam Maruthan Karthik Madhumathi Irulappan Rahul Shrivastava Hariharan Periasamy Balaji Veeraraghavan β-Lactam Resistance in ESKAPE Pathogens Mediated Through Modifications in Penicillin-Binding Proteins: An Overview Infectious Diseases and Therapy PBP ESKAPE Resistance β-Lactam Antibiotic Peptidoglycan |
| title | β-Lactam Resistance in ESKAPE Pathogens Mediated Through Modifications in Penicillin-Binding Proteins: An Overview |
| title_full | β-Lactam Resistance in ESKAPE Pathogens Mediated Through Modifications in Penicillin-Binding Proteins: An Overview |
| title_fullStr | β-Lactam Resistance in ESKAPE Pathogens Mediated Through Modifications in Penicillin-Binding Proteins: An Overview |
| title_full_unstemmed | β-Lactam Resistance in ESKAPE Pathogens Mediated Through Modifications in Penicillin-Binding Proteins: An Overview |
| title_short | β-Lactam Resistance in ESKAPE Pathogens Mediated Through Modifications in Penicillin-Binding Proteins: An Overview |
| title_sort | β lactam resistance in eskape pathogens mediated through modifications in penicillin binding proteins an overview |
| topic | PBP ESKAPE Resistance β-Lactam Antibiotic Peptidoglycan |
| url | https://doi.org/10.1007/s40121-023-00771-8 |
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