β-Lactam Resistance in ESKAPE Pathogens Mediated Through Modifications in Penicillin-Binding Proteins: An Overview

β-Lactam Resistance in ESKAPE Pathogens Mediated Through Modifications in Penicillin-Binding Proteins: An Overview

Abstract Bacteria acquire β-lactam resistance through a multitude of mechanisms among which production of β-lactamases (enzymes that hydrolyze β-lactams) is the most common, especially in Gram-negatives. Structural changes in the high-molecular-weight, essential penicillin-binding proteins (PBPs) ar...

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Bibliographic Details
Main Authors: Dhiviya Prabaa Muthuirulandi Sethuvel, Yamuna Devi Bakthavatchalam, Maruthan Karthik, Madhumathi Irulappan, Rahul Shrivastava, Hariharan Periasamy, Balaji Veeraraghavan
Format: Article
Language:English
Published: Adis, Springer Healthcare 2023-03-01
Series:Infectious Diseases and Therapy
Subjects:
PBP
ESKAPE
Resistance
β-Lactam
Antibiotic
Peptidoglycan
Online Access:https://doi.org/10.1007/s40121-023-00771-8

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