Analysis of clinical data of different endometrial pathological types in perimenopausal women with abnormal uterine bleeding
ObjectiveEarly detection and diagnosis are important for improving the therapeutic effect and quality of life in patients with endometrial cancer (EC). This study aimed to analyze the clinical data of different endometrial pathological types in perimenopausal women with abnormal uterine bleeding (AU...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2024.1370681/full |
| _version_ | 1827338872749555712 |
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| author | Li Wang Shimin Quan E. Bai Xiaofeng Yang |
| author_facet | Li Wang Shimin Quan E. Bai Xiaofeng Yang |
| author_sort | Li Wang |
| collection | DOAJ |
| description | ObjectiveEarly detection and diagnosis are important for improving the therapeutic effect and quality of life in patients with endometrial cancer (EC). This study aimed to analyze the clinical data of different endometrial pathological types in perimenopausal women with abnormal uterine bleeding (AUB) in order to provide evidence for the prevention and early diagnosis of EC.MethodsA total of 462 perimenopausal women with AUB were enrolled in this prospective observational study. Endometrial biopsy was performed in patients with suspected endometrial lesions. According to the pathological examination results, the patients were divided into endometrial polyp group (EP) (n = 71), endometrial hyperplasia without atypia group (EH) (n = 59), atypical endometrial hyperplasia (AEH) (n = 36), and EC group (n = 27). The history risk factors and ultrasonic imaging characteristics of endometrium among the four groups were compared.ResultsTwenty-seven women were diagnosed with EC (5.84%). The prevalence rate of AEH and EC in the group of 51- to 55-year-old women was significantly higher than that in the groups of 40- to 45-year-old women and of 46- to 50-year-old women (P < 0.05). The age, body mass index, and history of diabetes gradually increased with the development of endometrial pathological types. In addition, the correlation index of endometrial blood flow increased gradually, and the proportion of uneven endometrial echo, unclear endometrial–myometrial junction (EMJ), and ovarian cyst also increased gradually. However, no statistically significant difference was found when comparing endometrial thickness (ET) and endometrial volume (EV) among endometrial pathological groups (P > 0.05). The ET, EV, endometrial vascularization index, endometrial flow index, and vascularization flow index in the ovarian cyst group were significantly higher (P < 0.05), and the proportion of uneven endometrium echo and unclear EMJ were significantly higher compared with that in the non-ovarian cyst group (P < 0.05).ConclusionsThe most common cause of perimenopausal women with AUB was benign endometrial lesions. However, women aged 51–55 years old with endometrial high risk factors and ovarian cyst should be alert to AEH and EC. Endometrial biopsy needs to be performed to determine endometrial malignancy in necessity. |
| first_indexed | 2024-03-07T19:40:55Z |
| format | Article |
| id | doaj.art-b7653d0d70684714a7dbb503b8d5f210 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-03-07T19:40:55Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-b7653d0d70684714a7dbb503b8d5f2102024-02-29T05:21:08ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2024-02-011410.3389/fonc.2024.13706811370681Analysis of clinical data of different endometrial pathological types in perimenopausal women with abnormal uterine bleedingLi WangShimin QuanE. BaiXiaofeng YangObjectiveEarly detection and diagnosis are important for improving the therapeutic effect and quality of life in patients with endometrial cancer (EC). This study aimed to analyze the clinical data of different endometrial pathological types in perimenopausal women with abnormal uterine bleeding (AUB) in order to provide evidence for the prevention and early diagnosis of EC.MethodsA total of 462 perimenopausal women with AUB were enrolled in this prospective observational study. Endometrial biopsy was performed in patients with suspected endometrial lesions. According to the pathological examination results, the patients were divided into endometrial polyp group (EP) (n = 71), endometrial hyperplasia without atypia group (EH) (n = 59), atypical endometrial hyperplasia (AEH) (n = 36), and EC group (n = 27). The history risk factors and ultrasonic imaging characteristics of endometrium among the four groups were compared.ResultsTwenty-seven women were diagnosed with EC (5.84%). The prevalence rate of AEH and EC in the group of 51- to 55-year-old women was significantly higher than that in the groups of 40- to 45-year-old women and of 46- to 50-year-old women (P < 0.05). The age, body mass index, and history of diabetes gradually increased with the development of endometrial pathological types. In addition, the correlation index of endometrial blood flow increased gradually, and the proportion of uneven endometrial echo, unclear endometrial–myometrial junction (EMJ), and ovarian cyst also increased gradually. However, no statistically significant difference was found when comparing endometrial thickness (ET) and endometrial volume (EV) among endometrial pathological groups (P > 0.05). The ET, EV, endometrial vascularization index, endometrial flow index, and vascularization flow index in the ovarian cyst group were significantly higher (P < 0.05), and the proportion of uneven endometrium echo and unclear EMJ were significantly higher compared with that in the non-ovarian cyst group (P < 0.05).ConclusionsThe most common cause of perimenopausal women with AUB was benign endometrial lesions. However, women aged 51–55 years old with endometrial high risk factors and ovarian cyst should be alert to AEH and EC. Endometrial biopsy needs to be performed to determine endometrial malignancy in necessity.https://www.frontiersin.org/articles/10.3389/fonc.2024.1370681/fullperimenopauseabnormal uterine bleedingendometrial cancerhistory risk factorsultrasonic imaging characteristicsovarian cyst |
| spellingShingle | Li Wang Shimin Quan E. Bai Xiaofeng Yang Analysis of clinical data of different endometrial pathological types in perimenopausal women with abnormal uterine bleeding Frontiers in Oncology perimenopause abnormal uterine bleeding endometrial cancer history risk factors ultrasonic imaging characteristics ovarian cyst |
| title | Analysis of clinical data of different endometrial pathological types in perimenopausal women with abnormal uterine bleeding |
| title_full | Analysis of clinical data of different endometrial pathological types in perimenopausal women with abnormal uterine bleeding |
| title_fullStr | Analysis of clinical data of different endometrial pathological types in perimenopausal women with abnormal uterine bleeding |
| title_full_unstemmed | Analysis of clinical data of different endometrial pathological types in perimenopausal women with abnormal uterine bleeding |
| title_short | Analysis of clinical data of different endometrial pathological types in perimenopausal women with abnormal uterine bleeding |
| title_sort | analysis of clinical data of different endometrial pathological types in perimenopausal women with abnormal uterine bleeding |
| topic | perimenopause abnormal uterine bleeding endometrial cancer history risk factors ultrasonic imaging characteristics ovarian cyst |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2024.1370681/full |
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