Quercetin Attenuates Quinocetone-Induced Cell Apoptosis In Vitro by Activating the P38/Nrf2/HO-1 Pathway and Inhibiting the ROS/Mitochondrial Apoptotic Pathway

Quercetin Attenuates Quinocetone-Induced Cell Apoptosis In Vitro by Activating the P38/Nrf2/HO-1 Pathway and Inhibiting the ROS/Mitochondrial Apoptotic Pathway

Quinocetone (QCT), a member of the quinoxaline 1,4-di-<i>N</i>-oxides (QdNOs) family, can cause genotoxicity and hepatotoxicity, however, the precise molecular mechanisms of QCT are unclear. This present study investigated the protective effect of quercetin on QCT-induced cytotoxicity an...

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Bibliographic Details
Main Authors: Chongshan Dai, Qinzhi Zhang, Linjie Shen, Gaurav Sharma, Haiyang Jiang, Zhanhui Wang, Jianzhong Shen
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Antioxidants
Subjects:
quercetin
quinocetone
oxidative stress
apoptosis
p38/Nrf2/HO-1 pathway
NF-κB pathway
Online Access:https://www.mdpi.com/2076-3921/11/8/1498

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https://www.mdpi.com/2076-3921/11/8/1498

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