Methods of Respiratory Virus Detection: Advances towards Point-of-Care for Early Intervention
Respiratory viral infections threaten human life and inflict an enormous healthcare burden worldwide. Frequent monitoring of viral antibodies and viral load can effectively help to control the spread of the virus and make timely interventions. However, current methods for detecting viral load requir...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | Micromachines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-666X/12/6/697 |
| _version_ | 1797530141328408576 |
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| author | Siming Lu Sha Lin Hongrui Zhang Liguo Liang Shien Shen |
| author_facet | Siming Lu Sha Lin Hongrui Zhang Liguo Liang Shien Shen |
| author_sort | Siming Lu |
| collection | DOAJ |
| description | Respiratory viral infections threaten human life and inflict an enormous healthcare burden worldwide. Frequent monitoring of viral antibodies and viral load can effectively help to control the spread of the virus and make timely interventions. However, current methods for detecting viral load require dedicated personnel and are time-consuming. Additionally, COVID-19 detection is generally relied on an automated PCR analyzer, which is highly instrument-dependent and expensive. As such, emerging technologies in the development of respiratory viral load assays for point-of-care (POC) testing are urgently needed for viral screening. Recent advances in loop-mediated isothermal amplification (LAMP), biosensors, nanotechnology-based paper strips and microfluidics offer new strategies to develop a rapid, low-cost, and user-friendly respiratory viral monitoring platform. In this review, we summarized the traditional methods in respiratory virus detection and present the state-of-art technologies in the monitoring of respiratory virus at POC. |
| first_indexed | 2024-03-10T10:24:45Z |
| format | Article |
| id | doaj.art-b766a472f6924239af4a2af338a3036c |
| institution | Directory Open Access Journal |
| issn | 2072-666X |
| language | English |
| last_indexed | 2024-03-10T10:24:45Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Micromachines |
| spelling | doaj.art-b766a472f6924239af4a2af338a3036c2023-11-22T00:06:59ZengMDPI AGMicromachines2072-666X2021-06-0112669710.3390/mi12060697Methods of Respiratory Virus Detection: Advances towards Point-of-Care for Early InterventionSiming Lu0Sha Lin1Hongrui Zhang2Liguo Liang3Shien Shen4Department of Clinical Laboratory, Zhejiang Hospital, Hangzhou 310003, ChinaDepartment of Laboratory Medicine, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, ChinaDepartment of Clinical Laboratory, Zhejiang Hospital, Hangzhou 310003, ChinaDepartment of Laboratory Medicine, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, ChinaDepartment of Clinical Laboratory, Zhejiang Hospital, Hangzhou 310003, ChinaRespiratory viral infections threaten human life and inflict an enormous healthcare burden worldwide. Frequent monitoring of viral antibodies and viral load can effectively help to control the spread of the virus and make timely interventions. However, current methods for detecting viral load require dedicated personnel and are time-consuming. Additionally, COVID-19 detection is generally relied on an automated PCR analyzer, which is highly instrument-dependent and expensive. As such, emerging technologies in the development of respiratory viral load assays for point-of-care (POC) testing are urgently needed for viral screening. Recent advances in loop-mediated isothermal amplification (LAMP), biosensors, nanotechnology-based paper strips and microfluidics offer new strategies to develop a rapid, low-cost, and user-friendly respiratory viral monitoring platform. In this review, we summarized the traditional methods in respiratory virus detection and present the state-of-art technologies in the monitoring of respiratory virus at POC.https://www.mdpi.com/2072-666X/12/6/697COVID-19point-of-carerespiratory virusdetection |
| spellingShingle | Siming Lu Sha Lin Hongrui Zhang Liguo Liang Shien Shen Methods of Respiratory Virus Detection: Advances towards Point-of-Care for Early Intervention Micromachines COVID-19 point-of-care respiratory virus detection |
| title | Methods of Respiratory Virus Detection: Advances towards Point-of-Care for Early Intervention |
| title_full | Methods of Respiratory Virus Detection: Advances towards Point-of-Care for Early Intervention |
| title_fullStr | Methods of Respiratory Virus Detection: Advances towards Point-of-Care for Early Intervention |
| title_full_unstemmed | Methods of Respiratory Virus Detection: Advances towards Point-of-Care for Early Intervention |
| title_short | Methods of Respiratory Virus Detection: Advances towards Point-of-Care for Early Intervention |
| title_sort | methods of respiratory virus detection advances towards point of care for early intervention |
| topic | COVID-19 point-of-care respiratory virus detection |
| url | https://www.mdpi.com/2072-666X/12/6/697 |
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